1.14.99.24: steroid 9alpha-monooxygenase
This is an abbreviated version!
For detailed information about steroid 9alpha-monooxygenase, go to the full flat file.
Word Map on EC 1.14.99.24
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1.14.99.24
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synthesis
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4-androstene-3,17-dione
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3-ketosteroids
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medicine
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rhodococcus
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two-component
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oxygenases
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1,4-androstadiene-3,17-dione
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flavin
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unmarked
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iron-sulfur
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erythropolis
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tuberculosis
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smegmatis
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cholesterol
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delta1-dehydrogenase
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sterol
- 1.14.99.24
- synthesis
- 4-androstene-3,17-dione
- 3-ketosteroids
- medicine
- rhodococcus
-
two-component
- oxygenases
- 1,4-androstadiene-3,17-dione
- flavin
-
unmarked
-
iron-sulfur
- erythropolis
- tuberculosis
- smegmatis
- cholesterol
-
delta1-dehydrogenase
- sterol
Reaction
Synonyms
3-ketosteroid 9alpha-hydroxylase, KSH, steroid 9alpha-hydroxylase
ECTree
1.14.99.24 steroid 9alpha-monooxygenaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 1.14.99.24 - steroid 9alpha-monooxygenase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4,9(11)-pregnadiene-3,20-dione + NADH + O2
9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O
9(11)-dehydro-17alpha-methyl-testosterone + NADH + O2
9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-4-androstene-3-one + 9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-1,4-androstadiene-3-one + NAD+ + H2O
1,4-androstadiene-3,17-dione + 2 O2 + 2 H+
9-hydroxy-1,4-androstadiene-3,17-dione + H2O2
-
-
-
-
?
1,4-androstadiene-3,17-dione + 2 O2 + 2 H+
9-hydroxy-1,4-androstadiene-3,17-dione + H2O2
-
-
-
-
?
4,9(11)-pregnadiene-3,20-dione + NADH + O2
9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O
-
-
-
-
?
4,9(11)-pregnadiene-3,20-dione + NADH + O2
9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O
-
-
-
-
?
4,9(11)-pregnadiene-3,20-dione + NADH + O2
9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O
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key enzyme system in steroid nucleus degradation in company with delta-dehydrogenase
-
-
?
4,9(11)-pregnadiene-3,20-dione + NADH + O2
9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O
-
-
-
-
?
4,9(11)-pregnadiene-3,20-dione + NADH + O2
9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O
-
-
-
-
?
4,9(11)-pregnadiene-3,20-dione + NADH + O2
9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O
-
-
-
-
?
4,9(11)-pregnadiene-3,20-dione + NADH + O2
9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O
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key-enzyme in the steroid-ring-B-splitting pathway
-
?
4,9(11)-pregnadiene-3,20-dione + NADH + O2
9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O
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key-enzyme in the steroid-ring-B-splitting pathway
-
?
4,9(11)-pregnadiene-3,20-dione + NADH + O2
9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O
-
-
-
-
?
4,9(11)-pregnadiene-3,20-dione + NADH + O2
9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O
-
-
-
-
?
4,9(11)-pregnadiene-3,20-dione + NADH + O2
9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O
-
-
-
-
?
4,9(11)-pregnadiene-3,20-dione + NADH + O2
9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O
-
-
-
-
?
4,9(11)-pregnadiene-3,20-dione + NADH + O2
9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O
Rhodococcus rhodochrous KCTC 1061 / ATCC 17895
-
-
-
-
?
4,9(11)-pregnadiene-3,20-dione + NADH + O2
9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O
-
-
-
-
?
4,9(11)-pregnadiene-3,20-dione + NADH + O2
9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O
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key enzyme system controlling the microbial 9alpha-hydroxylation of 4-androstene-3,17-dione
-
-
?
4,9(11)-pregnadiene-3,20-dione + NADH + O2
9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O
Rhodococcus sp. IOC-77
-
-
-
-
?
4,9(11)-pregnadiene-3,20-dione + NADH + O2
9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O
Rhodococcus sp. IOC-77
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key enzyme system controlling the microbial 9alpha-hydroxylation of 4-androstene-3,17-dione
-
-
?
4-androstene-3,17-dione + NADH + O2
9alpha-hydroxy-4-androstene-3,17-dione + NAD+ + H2O
-
-
-
?
4-androstene-3,17-dione + NADH + O2
9alpha-hydroxy-4-androstene-3,17-dione + NAD+ + H2O
-
-
-
-
?
4-androstene-3,17-dione + NADH + O2
9alpha-hydroxy-4-androstene-3,17-dione + NAD+ + H2O
-
-
-
-
?
4-androstene-3,17-dione + NADH + O2
9alpha-hydroxy-4-androstene-3,17-dione + NAD+ + H2O
Rhodococcus sp. IOC-77
-
-
-
-
?
9(11)-dehydro-17alpha-methyl-testosterone + NADH + O2
9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-4-androstene-3-one + 9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-1,4-androstadiene-3-one + NAD+ + H2O
-
-
-
-
?
9(11)-dehydro-17alpha-methyl-testosterone + NADH + O2
9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-4-androstene-3-one + 9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-1,4-androstadiene-3-one + NAD+ + H2O
-
-
-
-
?
9(11)-dehydro-17alpha-methyl-testosterone + NADH + O2
9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-4-androstene-3-one + 9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-1,4-androstadiene-3-one + NAD+ + H2O
-
-
-
-
?
9(11)-dehydro-17alpha-methyl-testosterone + NADH + O2
9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-4-androstene-3-one + 9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-1,4-androstadiene-3-one + NAD+ + H2O
-
-
-
-
?
9(11)-dehydro-17alpha-methyl-testosterone + NADH + O2
9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-4-androstene-3-one + 9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-1,4-androstadiene-3-one + NAD+ + H2O
-
-
-
-
?
9(11)-dehydro-17alpha-methyl-testosterone + NADH + O2
9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-4-androstene-3-one + 9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-1,4-androstadiene-3-one + NAD+ + H2O
Rhodococcus rhodochrous KCTC 1061 / ATCC 17895
-
-
-
-
?
9(11)-dehydro-17alpha-methyl-testosterone + NADH + O2
9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-4-androstene-3-one + 9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-1,4-androstadiene-3-one + NAD+ + H2O
-
-
-
-
?
progesterone + AH2 + O2
9alpha-hydroxyprogesterone + A + H2O
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reaction with whole cells in a bioreactor
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-
?
progesterone + AH2 + O2
9alpha-hydroxyprogesterone + A + H2O
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reaction with whole cells in a bioreactor, low in vitro activity
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-
?
additional information
?
-
KSH cleaves the side chain specifically from soybean phytosterols to accumulate 4-androstene-3,17-dione and 1,4-androstadiene-3,17-dione
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-
?
additional information
?
-
-
KSH cleaves the side chain specifically from soybean phytosterols to accumulate 4-androstene-3,17-dione and 1,4-androstadiene-3,17-dione
-
-
?
additional information
?
-
Mycolicibacterium neoaurum NwIB-01
KSH cleaves the side chain specifically from soybean phytosterols to accumulate 4-androstene-3,17-dione and 1,4-androstadiene-3,17-dione
-
-
?
additional information
?
-
-
product determination and identification by LLE, HPLC-DAD, MS, and NMR, overview
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-
?
