1.14.99.22: ecdysone 20-monooxygenase
This is an abbreviated version!
For detailed information about ecdysone 20-monooxygenase, go to the full flat file.
Word Map on EC 1.14.99.22
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1.14.99.22
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20-hydroxyecdysone
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ecdysteroids
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instar
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molt
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midguts
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manduca
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sexta
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wandering
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malpighian
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halloween
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hornworm
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ecdysteroidogenesis
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shade
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prothoracic
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moulting
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migratoria
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nondiapause
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neverland
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cyp18a1
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larval-pupal
- 1.14.99.22
- 20-hydroxyecdysone
- ecdysteroids
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instar
-
molt
- midguts
- manduca
- sexta
-
wandering
-
malpighian
-
halloween
- hornworm
-
ecdysteroidogenesis
-
shade
-
prothoracic
-
moulting
- migratoria
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nondiapause
- neverland
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cyp18a1
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larval-pupal
Reaction
Synonyms
alpha-ecdysone C-20 hydroxylase, BmE20OHase, Cyp314A1, E-20-M, E20-M, E20M, E20MO, E20OHase, ecdysone 20-hydroxylase, ecdysone 20-monooxygenase, shade, shd
ECTree
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General Information
General Information on EC 1.14.99.22 - ecdysone 20-monooxygenase
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malfunction
physiological function
additional information
RNAi-mediated knockdown of Shade negatively affects ecdysone-20-hydroxylation in the desert locust
malfunction
enzyme knockdown causes larval lethality, delayed development and affects pupation
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essential need for conversion of the molting hormone, ecdysone, to its physiologically active form, 20-hydroxyecdysone by E20-M during the post-embryonic development
physiological function
in the desert locust, the Halloween gene SgShd plays a role in the biosynthesis of 20-hydroxyecdysone
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in the pupa of the silkworm, Bombyx mori, the rectal sac is an essential organ that operates as a repository for degraded ecdysteroids, and it can be distended by administration of 20-hydroxyecdysone
additional information
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physiological and developmental significance of the mitochondrial, NADPH-forming energy-linked transhydrogenations, that catalyzes a reversible hydride ion transfer between NADP(H) and NAD(H), for E20-M activity. NADPH-forming activity occurs as a nonenergy- or energy-linked activity with energy for the latter derived from either electron transport-dependent NADH or succinate utilization, or ATP hydrolysis by Mg2+-dependent ATPase, overview