1.14.99.14: progesterone 11alpha-monooxygenase

This is an abbreviated version!
For detailed information about progesterone 11alpha-monooxygenase, go to the full flat file.

Reaction

Synonyms

CYP106A2, CYP5311B1, progesterone 11alpha-hydroxylase, steroid 11alpha-hydroxylase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.99 Miscellaneous

1.14.99.14 progesterone 11alpha-monooxygenase

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Results	in table
14	Activating Compound
2	AA Sequence
4	Application
1	CAS Registry Number
3	Cloned(Commentary)
11	Cofactor
2	Expression
2	General Stability
11	Inhibitors
15	kcat/KM [mM/s]
14	KM Value [mM]
18	Localization
1	Molecular Weight [Da]
42	Natural Substrates/ Products (Substrates)
49	Organism
1	Pathway
1	pH Optimum
17	Protein Variants
2	Purification (Commentary)
1	Reaction
3	Reaction Type
37	Reference
15	Source Tissue
2	Specific Activity [micromol/min/mg]
61	Substrates and Products (Substrate)
4	Subunits
6	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Stability [°C]
15	Turnover Number [1/s]

Cloned

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Cloned on EC 1.14.99.14 - progesterone 11alpha-monooxygenase

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expressed in Pichia pastoris GS115 cells

Absidia caerulea

A0A173GQ95

745647

expressed in Rhizopus nigericans

Rhizopus arrhizus

744807

gene CYP509C12, cloning from a cDNA library, DNA and amino acid sequence determination and analysis, phylogenetic analysis, and recombinant expression in Pichia pastoris, coexpression with NAD(P)H-dependent reductase also from Rhizopus oryzae, which improves electron transfer to CYP509C12 and thus increases the production of 11-hydroxyprogesterone by 7fold. The engineered strain displays total bioconversion of progesterone into 11alpha-hydroxyprogesterone and small amounts of 6beta-hydroxyprogesterone

Rhizopus arrhizus

715693