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1.14.99.12: androst-4-ene-3,17-dione monooxygenase

This is an abbreviated version!
For detailed information about androst-4-ene-3,17-dione monooxygenase, go to the full flat file.

Word Map on EC 1.14.99.12

Reaction

androstenedione
+
reduced acceptor
+
O2
=
testololactone
+
acceptor
+
H2O

Synonyms

4-androstene-3,17-dione monooxygenase, androst-4-ene-3,17-dione 17-oxidoreductase, androst-4-ene-3,17-dione hydroxylase, androstene-3,17-dione hydroxylase, androstenedione monooxygenase, oxygenase, androstenedione mono-

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.99 Miscellaneous
                1.14.99.12 androst-4-ene-3,17-dione monooxygenase

Inhibitors

Inhibitors on EC 1.14.99.12 - androst-4-ene-3,17-dione monooxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5-Pregnene-3beta,20alpha-diol
-
-
5alpha-androstane-17beta-ol
-
exhibits an IC50 of 0.046 mM against androstendione 6beta-hydroxylase activity and an IC50 of 0.026 against androstendione 16alpha-hydroxylase activity and an IC50 of 0.047 against androstendione 16beta-hydroxylase activity
5alpha-androstane-3beta-ol
-
exhibits an IC50 of 0.11 mM against androstendione 6beta-hydroxylase activity and an IC50 of 0.071 mM against androstendione 16alpha-hydroxylase activity
5alpha-androstane-3beta-ol-17-one
-
exhibits an IC50 of 0.12 mM against androstendione 6beta-hydroxylase activity and an IC50 of 0.14 against androstendione 16beta-hydroxylase activity
5beta-androstane-17beta-ol
-
exhibits an IC50 of 0.11 mM against androstendione 6beta-hydroxylase activity and an IC50 of 0.065 against androstendione 16alpha-hydroxylase activity
5beta-androstane-3-one-17-one
-
exhibits an IC50 of 0.084 mM against androstendione 7alpha-hydroxylase activity
5beta-androstane-3beta-ol
-
exhibits an IC50 of 0.027 mM against androstendione 6beta-hydroxylase activity and an IC50 of 0.007 mM against androstendione 16alpha-hydroxylase activity
5beta-androstane-3beta-ol-17-one
-
exhibits an IC50 of 0.047 mM against androstendione 6beta-hydroxylase activity and an IC50 of 0.06 mM against androstendione 7alpha-hydroxylase activity and an IC50 of 0.051 against androstendione 16alpha-hydroxylase activity and an IC50 of 0.087 against androstendione 16beta-hydroxylase activity; exhibits an IC50 of 0.095 against androstendione 16alpha-hydroxylase activity
dehydroepiandrosterone
-
-
p-Mercuriphenylsulfonate
-
in presence of NADPH
pregnenolone
-
-
progesterone
-
-
testosterone
-
-
Testosterone acetate
-
-
additional information
-
5beta-reduced steroids are more potent inhibitors than 5alpha-reduced epimers
-