1.14.20.3: (5R)-carbapenem-3-carboxylate synthase
This is an abbreviated version!
For detailed information about (5R)-carbapenem-3-carboxylate synthase, go to the full flat file.
Reaction
Synonyms
carbapenem synthase, CarC
ECTree
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Natural Substrates Products on EC 1.14.20.3 - (5R)-carbapenem-3-carboxylate synthase
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REACTION DIAGRAM
(3S,5S)-carbapen-2-am-3-carboxylate + 2-oxoglutarate + O2
(5R)-carbapen-2-em-3-carboxylate + succinate + CO2 + H2O
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the enzyme is involved in the biosynthesis of (5R)-carbapen-2-em-3-carboxylic acid the simplest structurally among the naturally occurring carbapenem beta-lactam antibiotics
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(3S,5S)-carbapenam-3-carboxylate + 2-oxoglutarate + O2
(5R)-carbapen-2-em-3-carboxylate + succinate + CO2 + H2O
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