1.14.19.49: tetracycline 7-halogenase

This is an abbreviated version!
For detailed information about tetracycline 7-halogenase, go to the full flat file.

Reaction

Synonyms

ctcP, Cts4

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.19 With oxidation of a pair of donors resulting in the reduction of O₂ to two molecules of water

                1.14.19.49 tetracycline 7-halogenase

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4	AA Sequence
2	Application
1	Cloned(Commentary)
1	Cofactor
4	General Information
1	KM Value [mM]
1	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
4	Organism
5	Pathway
4	PDB ID
1	Reaction
4	Reference
4	Substrates and Products (Substrate)
2	Subunits
5	Synonyms
1	Systematic Name
1	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.14.19.49 - tetracycline 7-halogenase

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SYSTEMATIC NAME

IUBMB Comments

tetracycline:FADH2 oxidoreductase (7-halogenating)

The enzyme, characterized from the bacterium Streptomyces aureofaciens, is a member of the flavin-dependent halogenase family. The enzyme forms a lysine chloramine intermediate on an internal lysine residue before transferring the chlorine to the substrate. It is stereo-selective for the 4S (natural) isomer of tetracycline. FADH2 is provided by a dedicated EC 1.5.1.36, flavin reductase (NADH).