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BRENDA support

1.14.19.49: tetracycline 7-halogenase

This is an abbreviated version!
For detailed information about tetracycline 7-halogenase, go to the full flat file.

Reaction

tetracycline
+
FADH2
+
chloride
+
O2
+
H+
=
7-chlorotetracycline
+
FAD
+ 2 H2O

Synonyms

ctcP, Cts4

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
                1.14.19.49 tetracycline 7-halogenase

Reference

Reference on EC 1.14.19.49 - tetracycline 7-halogenase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dairi, T.; Nakano, T.; Aisaka, K.; Katsumata, R.; Hasegawa, M.
Cloning and nucleotide sequence of the gene responsible for chlorination of tetracycline
Biosci. Biotechnol. Biochem.
59
1099-1106
1995
Kitasatospora aureofaciens (Q53659), Kitasatospora aureofaciens NRRL3203 (Q53659)
Manually annotated by BRENDA team
Zhu, T.; Cheng, X.; Liu, Y.; Deng, Z.; You, D.
Deciphering and engineering of the final step halogenase for improved chlortetracycline biosynthesis in industrial Streptomyces aureofaciens
Metab. Eng.
19
69-78
2013
Kitasatospora aureofaciens (S4S3E1), Kitasatospora aureofaciens F3 (S4S3E1)
Manually annotated by BRENDA team