1.14.19.44: acyl-CoA (8-3)-desaturase
This is an abbreviated version!
For detailed information about acyl-CoA (8-3)-desaturase, go to the full flat file.
Word Map on EC 1.14.19.44
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1.14.19.44
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6-desaturase
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polyunsaturated
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phospholipid
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arachidonic
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linoleic
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pufas
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eicosapentaenoic
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5-desaturation
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omega
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desaturases
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docosahexaenoic
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dihomo-gamma-linolenic
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gamma-linolenic
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eicosatrienoic
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alpha-linolenic
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eicosa-8,11,14-trienoic
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coconut
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linoleoyl-coa
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linseed
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fat-free
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elongase
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safflower
- 1.14.19.44
-
6-desaturase
-
polyunsaturated
- phospholipid
-
arachidonic
-
linoleic
-
pufas
-
eicosapentaenoic
-
5-desaturation
- omega
-
desaturases
-
docosahexaenoic
-
dihomo-gamma-linolenic
-
gamma-linolenic
-
eicosatrienoic
-
alpha-linolenic
-
eicosa-8,11,14-trienoic
-
coconut
- linoleoyl-coa
-
linseed
-
fat-free
- elongase
- safflower
Reaction
+ 2 ferrocytochrome b5 + + 2 H+ = + 2 ferricytochrome b5 + 2 H2O
Synonyms
acyl-CoA 5-desaturase, acyl-CoA 5-desaturase (methylene-interrupted), D5D, DELTA 5-desaturase, delta-5 desaturase, DELTA5-desaturase, FADDELTA5, FADS1
ECTree
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Systematic Name
Systematic Name on EC 1.14.19.44 - acyl-CoA (8-3)-desaturase
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DELTA8-acyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (5,6-cis-dehydrogenating)
The enzyme introduces a cis double bond at carbon 5 of acyl-CoAs that contain a double bond at position 8. The enzymes from algae, mosses, mammals and the protozoan Leishmania major catalyse the desaturation of dihomo-gamma-linoleate [(8Z,11Z,14Z)-icosa-8,11,14-trienoate] and (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoate to generate arachidonate and (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoate, respectively. The enzyme contains a cytochrome b5 domain that acts as the direct electron donor to the desaturase active site and does not require an external cytochrome. cf. EC 1.14.19.37, acyl-CoA 5-desaturase.