1.14.19.3: acyl-CoA 6-desaturase
This is an abbreviated version!
For detailed information about acyl-CoA 6-desaturase, go to the full flat file.
Word Map on EC 1.14.19.3
-
1.14.19.3
-
polyunsaturated
-
arachidonic
-
desaturation
-
pufas
-
phospholipid
-
docosahexaenoic
-
eicosapentaenoic
-
gamma-linolenic
-
unsaturated
-
cholesterol
-
alpha-linolenic
-
elongase
-
triglyceride
-
la
-
lc-pufas
-
palmitic
-
elovl5
-
adipose
-
delta-5
-
monounsaturated
-
triacylglycerols
-
stearoyl-coa
-
linolenic
-
prostaglandin
-
phosphatidylcholine
-
dihomo-gamma-linolenic
-
eicosanoids
-
omega-6
-
delta5-desaturase
-
5-desaturase
-
linseed
-
borage
-
evening
-
stearic
-
primrose
-
teleost
-
palmitoleic
-
stearidonic
-
eczema
-
mortierella
-
seabream
-
alpina
-
srebf1
-
eicosatrienoic
-
synthesis
-
nutrition
-
safflower
-
desaturase-1
-
gilthead
-
aurata
-
flaxseed
-
stearoyl
-
diagnostics
-
drug development
- 1.14.19.3
-
polyunsaturated
-
arachidonic
-
desaturation
-
pufas
- phospholipid
-
docosahexaenoic
-
eicosapentaenoic
-
gamma-linolenic
- unsaturated
- cholesterol
-
alpha-linolenic
- elongase
- triglyceride
- la
-
lc-pufas
-
palmitic
- elovl5
- adipose
-
delta-5
-
monounsaturated
- triacylglycerols
- stearoyl-coa
-
linolenic
- prostaglandin
- phosphatidylcholine
-
dihomo-gamma-linolenic
-
eicosanoids
-
omega-6
- delta5-desaturase
-
5-desaturase
-
linseed
-
borage
-
evening
-
stearic
- primrose
-
teleost
-
palmitoleic
-
stearidonic
- eczema
- mortierella
- seabream
- alpina
-
srebf1
-
eicosatrienoic
- synthesis
- nutrition
- safflower
-
desaturase-1
-
gilthead
- aurata
-
flaxseed
-
stearoyl
- diagnostics
- drug development
Reaction
Synonyms
acyl-CoA DELTA6-desaturase, acyl-CoA desaturase, acyl-CoA-dependent DELTA6-desaturase, AsD6DES, D6 desaturase, d6-des, D6D, D6Des, DEALTA6I, delta 6 desaturase, DELTA 6-desaturase, delta 6-fatty acid desaturase, DELTA-6 desaturase, delta-6 fatty acid desaturase, DELTA-6-desaturase, DELTA6 desaturase, DELTA6 fatty acid desaturase, DELTA6 fatty acyl desaturase, DELTA6-acyl CoA desaturase, DELTA6-acyl-group desaturase, DELTA6-desaturase, DELTA6-desaturase II, DELTA6-fatty acid desaturase, DELTA6-fatty acyl-CoA desaturase, delta61, DELTA6fad_b, DES6, desaturase, fatty acid DA6-, desaturase, linoleate, DesI, EaD6DES, EC 1.14.99.25, FA desaturase 2, FADS2, FADS6, fadsd6, FAT-3, fatty acid 6-desaturase, fatty acid DA6-desaturase, fatty acid DELTA 6-desaturase, fatty acid delta-6 desaturase, fatty acid DELTA6-desaturase, fatty acid desaturase 2, fatty acid desaturase-2, GcFADS2, linoleate desaturase, linoleic acid desaturase, linoleic desaturase, linoleoyl CoA desaturase, linoleoyl-coenzyme A desaturase, long-chain fatty acid DELTA6-desaturase, MaFADS6, MaFADS6-I, Md6, MpFADS6, PiDesD6, TpFADS2
ECTree
1.14.19.3 acyl-CoA 6-desaturaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 1.14.19.3 - acyl-CoA 6-desaturase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
alpha-linolenoyl-CoA + ferrocytochrome b5 + O2 + H+
stearidonoyl-CoA + ferricytochrome b5 + H2O
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
linoleoyl-CoA + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-CoA + ferricytochrome b5 + H2O
palmitate + AH2 + O2
sapienate + A + H2O
the enzyme is a component of the lipid metabolic pathway that converts the essential fatty acids linoleate and alpha-linolenate into long-chain polyunsaturated fatty acids. The DELTA-6 desaturase/FADS2 expressed in human sebocytes catalyzes the conversion of palmitate into sapienate
-
-
?
palmitic acid + AH2 + O2
hexadec-6-enoic acid + A + H2O
-
key enzyme required for numerous vital functions involving distinct polyunsaturated fatty acids and polyunsaturated fatty acid-derived bioactive lipids. It seems that the biological importance of DELTA6-desaturase activity should also be considered for its newly identified role in the control of the biosynthesis of a monoenoic fatty acid (C16:1 n-10), particularly in tissues with low DELTA9-desaturase activity
-
-
?
alpha-linolenic acid + AH2 + O2
octadec-6,9,12,15-tetraenoic acid + A + 2 H2O
the enzyme is responsible for the first and rate-limiting step in biosynthesis of highly unsaturated fatty acids
-
-
?
alpha-linolenic acid + AH2 + O2
octadec-6,9,12,15-tetraenoic acid + A + 2 H2O
the enzyme is responsible for the first and rate-limiting step in biosynthesis of highly unsaturated fatty acids
-
-
?
alpha-linolenic acid + AH2 + O2
octadec-6,9,12,15-tetraenoic acid + A + 2 H2O
-
the enzyme is responsible for the first and rate-limiting step in biosynthesis of highly unsaturated fatty acids
-
-
?
alpha-linolenic acid + AH2 + O2
octadec-6,9,12,15-tetraenoic acid + A + 2 H2O
the enzyme is responsible for the first and rate-limiting step in biosynthesis of highly unsaturated fatty acids
-
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
preferred substrate
-
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
preferred substrate
-
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
alpha-linolenoyl-CoA + ferrocytochrome b5 + O2 + H+
stearidonoyl-CoA + ferricytochrome b5 + H2O
-
-
-
-
?
alpha-linolenoyl-CoA + ferrocytochrome b5 + O2 + H+
stearidonoyl-CoA + ferricytochrome b5 + H2O
-
-
-
-
?
alpha-linolenoyl-CoA + ferrocytochrome b5 + O2 + H+
stearidonoyl-CoA + ferricytochrome b5 + H2O
-
-
-
?
alpha-linolenoyl-CoA + ferrocytochrome b5 + O2 + H+
stearidonoyl-CoA + ferricytochrome b5 + H2O
-
-
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
the enzyme is responsible for the first and rate-limiting step in biosynthesis of highly unsaturated fatty acids
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
key enzyme localized in the endoplasmic reticulum
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
important for the generation of unsaturated fatty acids, DELTA6-desaturase required for the conversion of dietary linoleic acid to arachidonic acid
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
DELTA6-desaturase reaction is the rate-limiting step in the conversion of linoleic acid and alpha linoleic acids to the longer, more highly unsaturated members of the n-6 and n-3 polyunsaturated fatty acids, metabolic pathway in mammalian cells
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
DELTA6-desaturase reaction is the rate-limiting step in the conversion of linoleic acid and alpha linoleic acids to the longer, more highly unsaturated members of the n-6 and n-3 polyunsaturated fatty acids, metabolic pathway in mammalian cells
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
the enzyme is responsible for the first and rate-limiting step in biosynthesis of highly unsaturated fatty acids
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
important for the generation of unsaturated fatty acids, DELTA6-desaturase required for the conversion of dietary linoleic acid to arachidonic acid
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
DELTA6-desaturase reaction is the rate-limiting step in the conversion of linoleic acid and alpha linoleic acids to the longer, more highly unsaturated members of the n-6 and n-3 polyunsaturated fatty acids, metabolic pathway in mammalian cells
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
the enzyme is responsible for the first and rate-limiting step in biosynthesis of highly unsaturated fatty acids
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
the enzyme is responsible for the first and rate-limiting step in biosynthesis of highly unsaturated fatty acids
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
preferred substrate
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
preferred substrate
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
linoleoyl-CoA + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-CoA + ferricytochrome b5 + H2O
-
-
-
-
?
linoleoyl-CoA + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-CoA + ferricytochrome b5 + H2O
-
-
-
-
?
linoleoyl-CoA + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-CoA + ferricytochrome b5 + H2O
-
-
-
-
?
linoleoyl-CoA + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-CoA + ferricytochrome b5 + H2O
-
-
-
-
?
additional information
?
-
the zebrafish enzyme is a bifunctional DELTA5/DELTA6 desaturase
-
-
?
additional information
?
-
-
the enzyme is essential for the formation of long-chain metabolites from dietary linoleic acid and alpha-linolenic acid, but shows a slow activity in humans. A defect in the activity of DELTA6 and DELTA5 desaturases decreases the formation of gamma-linolenic acid, dihomo-gamma-linoleic acid, arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid from dietary linoleic acid, and alpha-linolenic acid. This, in turn, leads to inadequate formation of prostaglandins E1 and I3, prostacyclin, lipoxins resolvins, neuroprotectin D1, NO, and nitrolipids that have anti-inflammatory and platelet anti-aggregatory actions, inhibit leukocyte activation, augment wound healing, and resolve inflammation and thus, leads to the initiation and progression of atheroslcerosis, metabolism of essential fatty acids, overview, enzyme activity is decreased in diabetes mellitus, hypertension, hyperlipidemia, and metabolic syndrome X
-
-
?
additional information
?
-
-
D6D activity in preterm, term, and post-natals is estimated by the 20:3n-6/18:2n-6 ratio
-
-
?
additional information
?
-
-
PiDes6 desaturates both omegax6 and omega3 substrates, substrate specificity in comparison to other fatty acid desaturases, overview
-
-
?
additional information
?
-
delta 6 desaturase (FADS6) is a key bifunctional enzyme desaturating linoleic acid or alpha-linolenic acid, analysis of the molecular mechanism of substrate specificity, overview
-
-
?
additional information
?
-
-
delta 6 desaturase (FADS6) is a key bifunctional enzyme desaturating linoleic acid or alpha-linolenic acid, analysis of the molecular mechanism of substrate specificity, overview
-
-
?
additional information
?
-
delta 6 desaturase (FADS6) is a key bifunctional enzyme desaturating linoleic acid or alpha-linolenic acid, analysis of the molecular mechanism of substrate specificity, overview
-
-
?
additional information
?
-
delta 6 desaturase (FADS6) is a key bifunctional enzyme desaturating linoleic acid or alpha-linolenic acid, analysis of the molecular mechanism of substrate specificity, overview
-
-
?
additional information
?
-
-
delta 6 desaturase (FADS6) is a key bifunctional enzyme desaturating linoleic acid or alpha-linolenic acid, analysis of the molecular mechanism of substrate specificity, overview
-
-
?
additional information
?
-
polyunsaturated fatty acid profiles in Mortierella alpina, the lipids are synthesized mainly via the omega6 pathway and rarely via the omega3 pathway and as a result contain low alpha-linolenoyl-CoA and eicosapentaenoic acid levels
-
-
?
additional information
?
-
-
polyunsaturated fatty acid profiles in Mortierella alpina, the lipids are synthesized mainly via the omega6 pathway and rarely via the omega3 pathway and as a result contain low alpha-linolenoyl-CoA and eicosapentaenoic acid levels
-
-
?
additional information
?
-
delta 6 desaturase (FADS6) is a key bifunctional enzyme desaturating linoleic acid or alpha-linolenic acid, analysis of the molecular mechanism of substrate specificity, overview
-
-
?
additional information
?
-
polyunsaturated fatty acid profiles in Mortierella alpina, the lipids are synthesized mainly via the omega6 pathway and rarely via the omega3 pathway and as a result contain low alpha-linolenoyl-CoA and eicosapentaenoic acid levels
-
-
?
additional information
?
-
-
polyunsaturated fatty acid profiles in Mortierella alpina, the lipids are synthesized mainly via the omega6 pathway and rarely via the omega3 pathway and as a result contain low alpha-linolenoyl-CoA and eicosapentaenoic acid levels
-
-
?
additional information
?
-
fatty acid DELTA6-desaturation is the first commited step in C20 polyunsaturated fatty acid biosynthesis
-
-
?
additional information
?
-
fatty acid DELTA6-desaturation is the first commited step in C20 polyunsaturated fatty acid biosynthesis
-
-
?
