1.14.19.22: acyl-lipid omega-6 desaturase (cytochrome b5)

This is an abbreviated version!
For detailed information about acyl-lipid omega-6 desaturase (cytochrome b5), go to the full flat file.

Reaction

Synonyms

1-acyl-2-oleoyl-sn-glycero-3-phosphocholine DELTA12-desaturase, 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine DELTAl2-desaturase, 18:1-phosphatidylcholine desaturase, acyl-lipid DELTA12-desaturase, BrFAD2-1, CeFAT-2, CtFAD2-1, delta 12 fatty acid desaturase, delta-12 fatty acid desaturase 2, Delta-12 oleate desaturase, delta-twelve fatty acid desaturase 2, DELTA12 desaturase, DELTA12-desaturase, DELTA12-fatty acid desaturase, DELTA12-oleoyl-phosphatidylcholine desaturase, desaturase, oleate, DiFAD2, EC 1.3.1.35, endoplasmic reticulum-localized oleate desaturase, FAD2, FAD2-1, FAD2-1A, FAD2-1B, FAD2-2, FAD2-3, FAD2-4, FAD2A, FAD6, linoleate synthase, LKFAD15, microsomal oleate desaturase, microsomal oleic acid desaturase, microsomal omega-6 fatty acid desaturase, oleate desaturase, oleoyl phosphatidylcholine desaturase, oleoyl-CoA desaturase, oleoyl-PC desaturase, oleoyl-phosphatidylcholine desaturase, oleoylphosphatidylcholine desaturase, omega-6 desaturase, omega-6 fatty acid desaturase, omega-6-oleate desaturase, omega6-fatty acid desaturase, OsFAD2, plastidial oleate desaturase, seed-specific delta-12 fatty acid desaturase 2, SVE1, TauDELTA12des

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.19 With oxidation of a pair of donors resulting in the reduction of O₂ to two molecules of water

                1.14.19.22 acyl-lipid omega-6 desaturase (cytochrome b5)

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
3	Activating Compound
78	AA Sequence
2	Application
1	CAS Registry Number
23	Cloned(Commentary)
38	Cofactor
3	Expression
29	General Information
2	General Stability
14	Inhibitors
5	KM Value [mM]
58	Localization
1	Metals/Ions
6	Molecular Weight [Da]
35	Natural Substrates/ Products (Substrates)
74	Organism
2	Oxidation Stability
2	Pathway
1	pH Optimum
2	Posttranslational Modification
25	Protein Variants
2	Purification (Commentary)
2	Reaction
7	Reaction Type
68	Reference
77	Source Tissue
1	Specific Activity [micromol/min/mg]
63	Substrates and Products (Substrate)
8	Subunits
114	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
6	Temperature Stability [°C]

Systematic Name

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Systematic Name on EC 1.14.19.22 - acyl-lipid omega-6 desaturase (cytochrome b5)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide Go to Systematic Name Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

SYSTEMATIC NAME

IUBMB Comments

1-acyl-2-oleoyl-sn-glycero-3-phosphocholine,ferrocytochrome-b5:oxygen oxidoreductase (12,13 cis-dehydrogenating)

This microsomal enzyme introduces a cis double bond in fatty acids attached to lipid molecules at a location 6 carbons away from the methyl end of the fatty acid. The distance from the carboxylic acid end of the molecule does not affect the location of the new double bond. The most common substrates are oleoyl groups attached to either the sn-1 or sn-2 position of the glycerol backbone in phosphatidylcholine. cf. EC 1.14.19.23, acyl-lipid omega-6 desaturase (ferredoxin).