1.14.19.22: acyl-lipid omega-6 desaturase (cytochrome b5)

This is an abbreviated version!
For detailed information about acyl-lipid omega-6 desaturase (cytochrome b5), go to the full flat file.

Word Map on EC 1.14.19.22

1.14.19.22

linoleic

desaturases

polyunsaturated

desaturation

hypogaea

seed-specific

carthamus

tinctorius

hexadecadienoic

stearoyl-acp

high-oleate

agriculture

medicine

Reaction

+ 2 ferrocytochrome b5 +

+ 2 H+ =

+ 2 ferricytochrome b5 + 2 H2O

Synonyms

1-acyl-2-oleoyl-sn-glycero-3-phosphocholine DELTA12-desaturase, 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine DELTAl2-desaturase, 18:1-phosphatidylcholine desaturase, acyl-lipid DELTA12-desaturase, BrFAD2-1, CeFAT-2, CtFAD2-1, delta 12 fatty acid desaturase, delta-12 fatty acid desaturase 2, Delta-12 oleate desaturase, delta-twelve fatty acid desaturase 2, DELTA12 desaturase, DELTA12-desaturase, DELTA12-fatty acid desaturase, DELTA12-oleoyl-phosphatidylcholine desaturase, desaturase, oleate, DiFAD2, EC 1.3.1.35, endoplasmic reticulum-localized oleate desaturase, FAD2, FAD2-1, FAD2-1A, FAD2-1B, FAD2-2, FAD2-3, FAD2-4, FAD2A, FAD6, linoleate synthase, LKFAD15, microsomal oleate desaturase, microsomal oleic acid desaturase, microsomal omega-6 fatty acid desaturase, oleate desaturase, oleoyl phosphatidylcholine desaturase, oleoyl-CoA desaturase, oleoyl-PC desaturase, oleoyl-phosphatidylcholine desaturase, oleoylphosphatidylcholine desaturase, omega-6 desaturase, omega-6 fatty acid desaturase, omega-6-oleate desaturase, omega6-fatty acid desaturase, OsFAD2, plastidial oleate desaturase, seed-specific delta-12 fatty acid desaturase 2, SVE1, TauDELTA12des

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.19 With oxidation of a pair of donors resulting in the reduction of O₂ to two molecules of water

1.14.19.22 acyl-lipid omega-6 desaturase (cytochrome b5)

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Results	in table
3	Activating Compound
78	AA Sequence
2	Application
1	CAS Registry Number
23	Cloned(Commentary)
38	Cofactor
3	Expression
29	General Information
2	General Stability
14	Inhibitors
5	KM Value [mM]
58	Localization
1	Metals/Ions
6	Molecular Weight [Da]
35	Natural Substrates/ Products (Substrates)
74	Organism
2	Oxidation Stability
2	Pathway
1	pH Optimum
2	Posttranslational Modification
25	Protein Variants
2	Purification (Commentary)
2	Reaction
7	Reaction Type
68	Reference
77	Source Tissue
1	Specific Activity [micromol/min/mg]
63	Substrates and Products (Substrate)
8	Subunits
114	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
6	Temperature Stability [°C]

Substrates Products

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Substrates Products on EC 1.14.19.22 - acyl-lipid omega-6 desaturase (cytochrome b5)

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1,2-di-oleoyl-sn-glycero-3-phosphorylcholine + 2 ferrocytochrome b5 + O2 + 2 H+

1,2-di-linoleoyl-sn-glycero-3-phosphorylcholine + 2 ferricytochrome b5 + 2 H2O

Yarrowia lipolytica

desaturation takes place at both position-1 and position-2. The distearoyl or dielaidoyl phosphatidylcholines are not desaturated

390739

1,2-di-oleoyl-sn-glycero-3-phosphorylcholine + O2 + ?

Yarrowia lipolytica

390739

1,2-dioleoylphosphatidylcholine + 2 ferrocytochrome b5 + O2 + 2 H+

1,2-linoleoylphosphatidylcholine + 2 ferricytochrome b5 + 2 H2O

2 entries

1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + ferrocytochrome b5 + O2 + H+

1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + ferricytochrome b5 + H2O

16 entries

1-acyl-2-oleoyl-sn-glycero-3-phosphorylcholine + 2 ferrocytochrome b5 + O2 + 2 H+

1-acyl-2-linoleoyl-sn-glycero-3-phosphorylcholine + 2 ferricytochrome b5 + 2 H2O

Yarrowia lipolytica

390739

1-palmitoyl-2-oleoyl phosphatidylcholine + NAD+

1-palmitoyl-2-linoleoyl phosphatidylcholine + NADH

Pisum sativum

390733

1-stearoyl-2-oleoyl phosphatidylcholine + NAD+

1-stearoyl-2-linoleoyl phosphatidylcholine + NADH

Pisum sativum

390733

oleoyl-phosphatidylcholine + 2 ferrocytochrome b5 + O2 + 2 H+

linoleoyl-phosphatidylcholine + 2 ferricytochrome b5 + 2 H2O

Carthamus tinctorius

390728

oleoyl-[CoA] + ferrocytochrome b5 + O2 + H+

linoleoyl-[CoA] + ferricytochrome b5 + H2O

2 entries

oleoyl-[CoA] + phosphatidylcholine + O2 + H+

Arabidopsis thaliana

734120

oleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+

linoleoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O

Carthamus tinctorius

the IgG fraction from ascites fluid inhibits 62% of NADH-dependent cytochrome c reduction in safflower (Carthamus tinctorius L.) microsomes. These antibodies also block desaturation of oleic acid to linoleic acid in lipids of Carthamus tinctorius microsomes by 93%, suggesting that cytochrome b5 is the electron donor for the DELTA12 desaturase

731216

oleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+

linoleoyl-[glycerolipid] + ferricytochrome b5 + H2O

5 entries

oleoyl-[glycerolipid] + reduced ferredoxin [iron-sulfur] cluster + O2 + H+

linoleoyl-[glycerolipid] + oxidized ferredoxin [iron-sulfur] cluster + H2O

Nicotiana tabacum

Q6DMQ8

the enzyme inserts a double bond between the carbons 12 and 13 of monounsaturated oleic acid to generate polyunsaturated linoleic acid

734553

palmitoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+

hexadecadienoyl-[glycerolipid] + ferricytochrome b5 + H2O

2 entries

additional information

18 entries