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1,2-di-oleoyl-sn-glycero-3-phosphorylcholine + 2 ferrocytochrome b5 + O2 + 2 H+
1,2-di-linoleoyl-sn-glycero-3-phosphorylcholine + 2 ferricytochrome b5 + 2 H2O
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desaturation takes place at both position-1 and position-2. The distearoyl or dielaidoyl phosphatidylcholines are not desaturated
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1,2-di-oleoyl-sn-glycero-3-phosphorylcholine + O2 + ?
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1,2-dioleoylphosphatidylcholine + 2 ferrocytochrome b5 + O2 + 2 H+
1,2-linoleoylphosphatidylcholine + 2 ferricytochrome b5 + 2 H2O
1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + ferrocytochrome b5 + O2 + H+
1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + ferricytochrome b5 + H2O
1-acyl-2-oleoyl-sn-glycero-3-phosphorylcholine + 2 ferrocytochrome b5 + O2 + 2 H+
1-acyl-2-linoleoyl-sn-glycero-3-phosphorylcholine + 2 ferricytochrome b5 + 2 H2O
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?
1-palmitoyl-2-oleoyl phosphatidylcholine + NAD+
1-palmitoyl-2-linoleoyl phosphatidylcholine + NADH
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1-stearoyl-2-oleoyl phosphatidylcholine + NAD+
1-stearoyl-2-linoleoyl phosphatidylcholine + NADH
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?
oleoyl-phosphatidylcholine + 2 ferrocytochrome b5 + O2 + 2 H+
linoleoyl-phosphatidylcholine + 2 ferricytochrome b5 + 2 H2O
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oleoyl-[CoA] + ferrocytochrome b5 + O2 + H+
linoleoyl-[CoA] + ferricytochrome b5 + H2O
oleoyl-[CoA] + phosphatidylcholine + O2 + H+
?
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?
oleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
linoleoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O
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the IgG fraction from ascites fluid inhibits 62% of NADH-dependent cytochrome c reduction in safflower (Carthamus tinctorius L.) microsomes. These antibodies also block desaturation of oleic acid to linoleic acid in lipids of Carthamus tinctorius microsomes by 93%, suggesting that cytochrome b5 is the electron donor for the DELTA12 desaturase
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oleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
linoleoyl-[glycerolipid] + ferricytochrome b5 + H2O
oleoyl-[glycerolipid] + reduced ferredoxin [iron-sulfur] cluster + O2 + H+
linoleoyl-[glycerolipid] + oxidized ferredoxin [iron-sulfur] cluster + H2O
the enzyme inserts a double bond between the carbons 12 and 13 of monounsaturated oleic acid to generate polyunsaturated linoleic acid
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?
palmitoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
hexadecadienoyl-[glycerolipid] + ferricytochrome b5 + H2O
additional information
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1,2-dioleoylphosphatidylcholine + 2 ferrocytochrome b5 + O2 + 2 H+
1,2-linoleoylphosphatidylcholine + 2 ferricytochrome b5 + 2 H2O
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the rate of desaturation of endogenous oleoyl phosphatidylcholine is much greater that of exogenous dioleoyl phosphatidylcholine
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?
1,2-dioleoylphosphatidylcholine + 2 ferrocytochrome b5 + O2 + 2 H+
1,2-linoleoylphosphatidylcholine + 2 ferricytochrome b5 + 2 H2O
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the rate of desaturation of endogenous oleoyl phosphatidylcholine is much greater that of exogenous dioleoyl phosphatidylcholine
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?
1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + ferrocytochrome b5 + O2 + H+
1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + ferricytochrome b5 + H2O
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?
1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + ferrocytochrome b5 + O2 + H+
1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + ferricytochrome b5 + H2O
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?
1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + ferrocytochrome b5 + O2 + H+
1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + ferricytochrome b5 + H2O
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?
1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + ferrocytochrome b5 + O2 + H+
1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + ferricytochrome b5 + H2O
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?
1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + ferrocytochrome b5 + O2 + H+
1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + ferricytochrome b5 + H2O
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?
1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + ferrocytochrome b5 + O2 + H+
1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + ferricytochrome b5 + H2O
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?
1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + ferrocytochrome b5 + O2 + H+
1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + ferricytochrome b5 + H2O
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?
1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + ferrocytochrome b5 + O2 + H+
1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + ferricytochrome b5 + H2O
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?
1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + ferrocytochrome b5 + O2 + H+
1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + ferricytochrome b5 + H2O
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?
1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + ferrocytochrome b5 + O2 + H+
1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + ferricytochrome b5 + H2O
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?
1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + ferrocytochrome b5 + O2 + H+
1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + ferricytochrome b5 + H2O
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?
1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + ferrocytochrome b5 + O2 + H+
1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + ferricytochrome b5 + H2O
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?
1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + ferrocytochrome b5 + O2 + H+
1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + ferricytochrome b5 + H2O
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?
1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + ferrocytochrome b5 + O2 + H+
1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + ferricytochrome b5 + H2O
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?
1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + ferrocytochrome b5 + O2 + H+
1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + ferricytochrome b5 + H2O
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?
1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + ferrocytochrome b5 + O2 + H+
1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + ferricytochrome b5 + H2O
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?
oleoyl-[CoA] + ferrocytochrome b5 + O2 + H+
linoleoyl-[CoA] + ferricytochrome b5 + H2O
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oleoyl-[CoA] + ferrocytochrome b5 + O2 + H+
linoleoyl-[CoA] + ferricytochrome b5 + H2O
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oleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
linoleoyl-[glycerolipid] + ferricytochrome b5 + H2O
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oleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
linoleoyl-[glycerolipid] + ferricytochrome b5 + H2O
best substrate
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oleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
linoleoyl-[glycerolipid] + ferricytochrome b5 + H2O
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best substrate
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oleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
linoleoyl-[glycerolipid] + ferricytochrome b5 + H2O
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oleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
linoleoyl-[glycerolipid] + ferricytochrome b5 + H2O
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palmitoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
hexadecadienoyl-[glycerolipid] + ferricytochrome b5 + H2O
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palmitoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
hexadecadienoyl-[glycerolipid] + ferricytochrome b5 + H2O
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additional information
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wild-type enzyme has an inherent, low level of hydroxylation activity
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additional information
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a desaturase mutant that is unable to convert oleic acid to linoleic acid is impaired in polyunsaturated fatty acid biosynthesis, shows delayed spore germination, a twofold reduction in growth, a reduced level of conidiation and complete loss of eclerotial development, compared to the wild-type
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additional information
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CeFAT-2 displays characteristics of a bifunctional DELTA12/DELTA15-desaturase and has a great deal of elasticity with respect to fatty acid chain length in being able to desaturate fatty acids ranging from C14 to C18 at the DELTA12 and DELTA15 positions
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additional information
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yeast cells transformed with the plasmid construct pYES2/FAD2 produce a substantial amount of linoleic acid (18:2) after a period of galactose induction
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additional information
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yeast cells transformed with the plasmid construct pYES2/FAD2 produced a substantial amount of linoleic acid (18:2) after a period of galactose induction
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additional information
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esterification of oleate at position 1 and 2
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additional information
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yeast cells expressing CtFAD2-1 cDNA partially convert oleic fatty acid to linoleic fatty acid
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additional information
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esterification of oleate at position 1 and 2
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additional information
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LKFAD15 is a DELTA12/DELTA15 bifunctional fatty acid desaturase being able to produce linoleic acid and alpha-linolenic acid using oleic acid as substrate and also adjusting the omega-6/omega-3 fatty acids
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additional information
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recombinant yeast cells can convert oleic acid to linoleic acid
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additional information
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exogenously added oleic acid is converted to linoleic acid in the gene transformants but not mock transformants of Aurantiochytrium limacinum mh0186 and yeast cells
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additional information
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exogenously added oleic acid is converted to linoleic acid in the gene transformants but not mock transformants of Aurantiochytrium limacinum mh0186 and yeast cells
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additional information
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yeasts transformed with the tauDELTA12des converts endogenous oleic acid into linoleic acid
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additional information
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yeasts transformed with the tauDELTA12des converts endogenous oleic acid into linoleic acid
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additional information
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yeasts transformed with the tauDELTA12des converts endogenous oleic acid into linoleic acid
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additional information
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the enzyme may use a cytochrome b5-like domain in another desaturase as an electron donor
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additional information
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the enzyme may use a cytochrome b5-like domain in another desaturase as an electron donor
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additional information
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not: di-oleoyl phosphatidylcholine, dielaidoyl phosphatidylcholine
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