1.14.19.21: cholesterol 7-desaturase

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For detailed information about cholesterol 7-desaturase, go to the full flat file.

Reaction

Synonyms

C-7 cholesterol desaturase, C7-Des, cholesterol 7,8-dehydrogenase, DAF-36, DAF-36/Neverland, Des7, Des7p, Neverland, Nvd, PmNvd, Rieske domain oxygenase Neverland, sterol C7(8)-desaturase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.19 With oxidation of a pair of donors resulting in the reduction of O₂ to two molecules of water

                1.14.19.21 cholesterol 7-desaturase

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Results	in table
864	AA Sequence
8	Cloned(Commentary)
26	Cofactor
4	General Information
9	Localization
1	Metals/Ions
1	Molecular Weight [Da]
27	Natural Substrates/ Products (Substrates)
10	Organism
4	Pathway
6	Protein Variants
1	Reaction
10	Reference
2	Source Tissue
31	Substrates and Products (Substrate)
1	Subunits
27	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 1.14.19.21 - cholesterol 7-desaturase

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SYSTEMATIC NAME

IUBMB Comments

cholesterol,NAD(P)H:oxygen oxidoreductase (7,8 dehydrogenating)

The enzyme, characterized from several organisms including the worm Caenorhabditis elegans, the fly Drosophila melanogaster, and the ciliate Tetrahymena thermophila, is a Rieske oxygenase. In insects it participates in the the biosythesis of ecdysteroid hormones. The electrons are transferred from NAD(P)H via an electron transfer chain likely to include ferredoxin reductase and ferredoxin. The enzyme differs from regular desaturases, such as EC 1.14.19.20, 7-sterol 5(6)-desaturase, which are cytochrome b5-dependent and contain the three His-boxes that are typical to most desaturases.