1.14.19.21: cholesterol 7-desaturase

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For detailed information about cholesterol 7-desaturase, go to the full flat file.

Reaction

Synonyms

C-7 cholesterol desaturase, C7-Des, cholesterol 7,8-dehydrogenase, DAF-36, DAF-36/Neverland, Des7, Des7p, Neverland, Nvd, PmNvd, Rieske domain oxygenase Neverland, sterol C7(8)-desaturase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.19 With oxidation of a pair of donors resulting in the reduction of O₂ to two molecules of water

                1.14.19.21 cholesterol 7-desaturase

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Results	in table
864	AA Sequence
8	Cloned(Commentary)
26	Cofactor
4	General Information
9	Localization
1	Metals/Ions
1	Molecular Weight [Da]
27	Natural Substrates/ Products (Substrates)
10	Organism
4	Pathway
6	Protein Variants
1	Reaction
10	Reference
2	Source Tissue
31	Substrates and Products (Substrate)
1	Subunits
27	Synonyms
1	Systematic Name

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Reference on EC 1.14.19.21 - cholesterol 7-desaturase

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REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

723904

Wollam, J.; Magomedova, L.; Magner, D.B.; Shen, Y.; Rottiers, V.; Motola, D.L.; Mangelsdorf, D.J.; Cummins, C.L.; Antebi, A.

The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity

Aging Cell

10

879-884

2011

Caenorhabditis elegans

21749634

brenda

725431

Yoshiyama-Yanagawa, T.; Enya, S.; Shimada-Niwa, Y.; Yaguchi, S.; Haramoto, Y.; Matsuya, T.; Shiomi, K.; Sasakura, Y.; Takahashi, S.; Asashima, M.; Kataoka, H.; Niwa, R.

The conserved Rieske oxygenase DAF-36/Neverland is a novel cholesterol-metabolizing enzyme

J. Biol. Chem.

286

25756-25762

2011

Xenopus laevis (F7J184), Xenopus laevis, Ciona intestinalis (F7J186), Ciona intestinalis, Hemicentrotus pulcherrimus (F7J188), Hemicentrotus pulcherrimus, Caenorhabditis elegans (Q17938), Caenorhabditis elegans, Bombyx mori (Q1JUZ2), Bombyx mori, Danio rerio (Q6DHJ3), Danio rerio

21632547

brenda

725923

Najle, S.R.; Nusblat, A.D.; Nudel, C.B.; Uttaro, A.D.

The sterol-C7 desaturase from the ciliate Tetrahymena thermophila is a Rieske oxygenase, which is highly conserved in animals

Mol. Biol. Evol.

30

1630-1643

2013

Tetrahymena thermophila

23603937

brenda

735284

Poklepovich, T.; Urtasun, N.; Miranda, M.; Nusblat, A.; Nudel, C.

Expression and functional characterization of a C-7 cholesterol desaturase from Tetrahymena thermophila in an insect cell line

Steroids

96

132-139

2015

Tetrahymena thermophila (I7ML19), Tetrahymena thermophila

25681633

brenda

744745

Sathapondecha, P.; Panyim, S.; Udomkit, A.

An essential role of Rieske domain oxygenase Neverland in the molting cycle of black tiger shrimp, Penaeus monodon

Comp. Biochem. Physiol. A

213

11-19

2017

Penaeus monodon (A0A2I4PEL8), Penaeus monodon

28842223

brenda

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