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1.14.19.20: DELTA7-sterol 5(6)-desaturase

This is an abbreviated version!
For detailed information about DELTA7-sterol 5(6)-desaturase, go to the full flat file.

Word Map on EC 1.14.19.20

Reaction

a DELTA7-sterol
+ 2 ferrocytochrome b5 +
O2
+ 2 H+ =
a DELTA5,7-sterol
+ 2 ferricytochrome b5 + 2 H2O

Synonyms

5-DES, 5alpha-cholest-7-en-3beta-ol:oxygen DELTA5-oxidoreductase, C-5 sterol desaturase, C-5(6) sterol desaturase, Delta-7-sterol 5-desaturase, DELTA7-sterol 5-desaturase, DELTA7-sterol C56-desaturase, DELTA7-sterol DELTA5-dehydrogenase, DELTA7-sterol-C-5-desaturase, DELTA7-sterol-C5 (6)-desaturase, DELTA7-sterol-C5(6)-desaturase, DELTA7-sterol-C5-desaturase, DES5A, Des5Ap, Dhcr7, DWARF7, EC 1.14.21.6, EC 1.3.3.2, ERG 3, ERG3, erg32, Erg3p, FvC5SD, Lathosterol 5-desaturase, lathosterol oxidase, oxidase, lathosterol, Sc5d, SC5DL, SCSD, STE1, sterol C5-desaturase, sterol DELTA5,6-desaturase, sterol DELTA7-reductase, Sterol-C5-desaturase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
                1.14.19.20 DELTA7-sterol 5(6)-desaturase

Engineering

Engineering on EC 1.14.19.20 - DELTA7-sterol 5(6)-desaturase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
G234A
G234D
H147E
H147L
H151E
H151l
H161E
H161L
H164L
H165L
H203L
H222E
H222L
H238E
H238L
H241L
H242L
K115L
P175A
P175V
P201A
T114I
wild-type activity
T114I |
Km-value for 5alpha-cholest-7-en-3beta-ol is 7.5fold higher than that of wild-type activity
T114S
L193R
the mutation impairs enzyme function
G111R
additional information