1.14.19.18: sphingolipid 8-(E)-desaturase

This is an abbreviated version, for detailed information about sphingolipid 8-(E)-desaturase, go to the full flat file.

Reaction

a (4E)-sphing-4-enine ceramide
+ 2 ferrocytochrome b5 +
O2
 + 2 H+ =
a (4E,8E)-sphing-4,8-dienine ceramide
 + 2 ferricytochrome b5 + 2 H2O

Synonyms

8 fatty acid desaturase, 8-sphingolipid desaturase, D8A, D8B, D8C, D8D, DELTA8-sphingolipid desaturase, DesB, SLD, sphinganine DELTA8-desaturase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
                1.14.19.18 sphingolipid 8-(E)-desaturase