1.14.19.1: stearoyl-CoA 9-desaturase
This is an abbreviated version!
For detailed information about stearoyl-CoA 9-desaturase, go to the full flat file.
Word Map on EC 1.14.19.1
-
1.14.19.1
-
sickle
-
cardiac
-
children
-
ventricular
-
pain
-
hemoglobin
-
arrhythmia
-
vaso-occlusive
-
transfusion
-
anemia
-
infarct
-
cardiomyopathy
-
episode
-
cardiovascular
-
coronary
-
myocardial
-
artery
-
stratification
-
polyunsaturated
-
ejection
-
hydroxyurea
-
stroke
-
monounsaturated
-
crises
-
chest
-
defibrillator
-
desaturation
-
lipogenesis
-
arrhythmogenic
-
tachycardia
-
hemoglobinopathy
-
all-cause
-
cardioverter
-
pufas
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cardioverter-defibrillator
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desaturases
-
electrocardiogram
-
lipogenic
-
transfused
-
pharmacology
-
thalassemia
-
12-lead
-
palmitoleic
-
agriculture
-
tachyarrhythmias
-
caregiver
-
out-of-hospital
-
resynchronization
-
medicine
-
transcranial
-
syncope
-
drug development
-
holter
-
alloimmunization
- 1.14.19.1
-
sickle
- cardiac
- children
- ventricular
- pain
- hemoglobin
- arrhythmia
-
vaso-occlusive
-
transfusion
- anemia
- infarct
- cardiomyopathy
- episode
- cardiovascular
- coronary
- myocardial
- artery
-
stratification
-
polyunsaturated
-
ejection
- hydroxyurea
- stroke
-
monounsaturated
- crises
- chest
-
defibrillator
-
desaturation
-
lipogenesis
-
arrhythmogenic
- tachycardia
- hemoglobinopathy
-
all-cause
-
cardioverter
-
pufas
-
cardioverter-defibrillator
-
desaturases
-
electrocardiogram
-
lipogenic
-
transfused
- pharmacology
- thalassemia
-
12-lead
-
palmitoleic
- agriculture
- tachyarrhythmias
-
caregiver
-
out-of-hospital
-
resynchronization
- medicine
-
transcranial
- syncope
- drug development
-
holter
-
alloimmunization
Reaction
Synonyms
ACOD4, acyl coenzyme A desaturase, acyl-CoA desaturase, delta-9 desaturase, DELTA9 desaturase, DELTA9 fatty acid desaturase, DELTA9 terminal desaturase, DELTA9-acyl CoA desaturase, DELTA9-desaturase, DELTA9-fatty-acid desaturase, DELTA9D, DesA3, desaturase 9, Dpu-DELTA9-KPSE, EC 1.14.99.5, eicosatrienoyl-CoA desaturase, FAD9, fatty acid 9-desaturase, fatty acid DELTA9-desaturase, fatty acid desaturase, fatty acyl CoA DELTA9-desaturase, fatty acyl DELTA9-desaturase, fatty acyl-CoA desaturase, hSCD1, hSCD5, long-chain fatty acid DELTA9-desaturase, membrane-bound stearoyl-CoA DELTA9 desaturase, NPVE desaturase, palmitoyl CoA desaturase, palmitoyl-CoA desaturase, SCD, SCD-1, SCD-2, SCD-3, SCD-4, SCD1, SCD2, SCD3, SCD4, SCD5, stearoyl CoA desaturase, stearoyl coenzyme A desaturase, stearoyl coenzyme-A desaturase 1, stearoyl-ACP DELTA9 desaturase, stearoyl-CoA (DELTA8) desaturase, stearoyl-CoA desaturase, stearoyl-CoA desaturase 1, stearoyl-CoA desaturase 2, stearoyl-CoA desaturase enzyme-1, stearoyl-CoA desaturase-1, stearoyl-CoA desaturase-2, stearoyl-CoA desaturase-3, stearoyl-CoA desaturase-4, stearoyl-CoA desaturase-5, stearoyl-CoA desaturase1, stearoyl-CoA desaturase2, stearoyl-coenzyme A desaturase, stearoyl-coenzyme A desaturase-1, stearyl coenzyme A desaturase, stearyl-CoA desaturase, TkSCD-1, TkSCD-2
ECTree
1.14.19.1 stearoyl-CoA 9-desaturaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 1.14.19.1 - stearoyl-CoA 9-desaturase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
18-fluoro-10-thiaoctadecanoyl-[acyl-carrier protein] + O2 + ferredoxin
?
-
-
-
-
?
myristic acid + NADH + O2 + ATP + CoA
myristoleic acid + NAD+ + H2O + ?
-
reaction in presence of fatty acid-binding proteins with mixing at speeds between 250 and 500 rpm
-
-
?
palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
palmitoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
palmitoyl-CoA + ferrocytochrome b5 + O2
palmitoleoyl-CoA + ferricytochrome b5 + H2O
-
-
-
-
?
palmitoyl-CoA + ferrocytochrome b5 + O2 + 2 H+
palmitoleoyl-CoA + ferricytochrome b5 + 2 H2O
palmitoyl-CoA + NADPH + O2
palmitoleoyl-CoA + NADP+ + H2O
-
Angus and American Wagyu steers, corn-fed steers for 8 mo (short-fed) or 16 mo (long-fed), and hay-fed steers fed for 12 mo (short-fed) and 20 mo (long-fed)
-
-
?
stearoyl-CoA + ferrocytochrome b5 + H+ + O2
oleoyl-CoA + ferricytochrome b5 + H2O
-
-
-
-
?
N-hydroxy-benzenecarboximidamide + NADH + H+ + O2
benzamidine + NAD+ + H2O
-
-
-
-
?
N-hydroxy-benzenecarboximidamide + NADH + H+ + O2
benzamidine + NAD+ + H2O
-
-
-
-
?
palmitic acid + AH2 + O2
palmitoleic acid + A + H2O
Mortierella alpina CBS 528.72 / ATCC 32222
-
-
-
?
palmitic acid + reduced acceptor + O2
palmitoleic acid + acceptor + H2O
preferred substrate
-
-
?
palmitic acid + reduced acceptor + O2
palmitoleic acid + acceptor + H2O
-
-
-
-
?
palmitic acid + reduced acceptor + O2
palmitoleic acid + acceptor + H2O
-
-
-
-
?
palmitic acid + reduced acceptor + O2
palmitoleic acid + acceptor + H2O
-
isozyme Sls-FL2, preferred substrate
Z-isomer, both isozymes
-
?
palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
palmitoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
palmitoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
palmitoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
palmitoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
palmitoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
palmitoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
palmitoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
-
?
palmitoyl-CoA + AH2 + O2
palmitoleoyl-CoA + A
-
62% activity of the rate with stearoyl-CoA
-
-
?
palmitoyl-CoA + ferrocytochrome b5 + O2 + 2 H+
palmitoleoyl-CoA + ferricytochrome b5 + 2 H2O
-
-
-
-
?
palmitoyl-CoA + ferrocytochrome b5 + O2 + 2 H+
palmitoleoyl-CoA + ferricytochrome b5 + 2 H2O
-
a key step in triglyceride synthesis in the fatty acid metabolic network
-
-
?
palmitoyl-CoA + NADH + H+ + O2
palmitoleoyl-CoA + NAD+ + H2O
-
13% conversion
-
-
?
palmitoyl-CoA + NADH + H+ + O2
palmitoleoyl-CoA + NAD+ + H2O
-
main substrate
-
-
?
palmitoyl-CoA + NADH + O2
palmitoleoyl-CoA + NAD+ + H2O
-
SCD activity of microsomal fraction
-
-
?
palmitoyl-CoA + NADH + O2
palmitoleoyl-CoA + NAD+ + H2O
-
62% activity of stearoyl-CoA
-
-
?
palmitoyl-CoA + NADH + O2
palmitoleoyl-CoA + NAD+ + H2O
slight activity
-
-
?
stearate + AH2 + O2
oleate + A + 2 H2O
-
biosynthesis of unsaturated fatty acid, synthesis of triacylglycerol from oleate
-
?
stearate + reduced acceptor + O2
oleate + acceptor + H2O
-
isozyme Sls-FL1, preferred substrate
Z-isomer, both isozymes
-
?
stearic acid + AH2 + O2
oleic acid + A + H2O
the enzyme shows a preference for C18 saturated fatty acids
-
-
?
stearic acid + reduced acceptor + O2
oleic acid + acceptor + H2O
-
-
-
-
?
stearic acid + reduced acceptor + O2
oleic acid + acceptor + H2O
-
-
-
-
?
stearoyl-acyl-carrier protein + AH2 + O2
oleoyl-acyl-carrier protein + A + H2O
-
-
-
?
stearoyl-acyl-carrier protein + AH2 + O2
oleoyl-acyl-carrier protein + A + H2O
-
key regulator of fatty acid desaturation of carbons 9 and 10
-
?
stearoyl-acyl-carrier protein + AH2 + O2
oleoyl-acyl-carrier protein + A + H2O
-
insertion of a cis double bond between the 9 and 10 position, essential step in fatty acid biosynthesis
-
?
stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
-
?
stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
-
?
stearoyl-CoA + AH2 + O2
oleoyl-CoA + A + H2O
-
oleic acid biosynthesis
-
?
stearoyl-CoA + AH2 + O2
oleoyl-CoA + A + H2O
-
also other fatty acyl-CoA substrates
-
?
stearoyl-CoA + AH2 + O2
oleoyl-CoA + A + H2O
activity measured via the generation of tritium enriched water from the substrate 9,10-3H-steaoryl-CoA
-
-
?
stearoyl-CoA + ferrocytochrome b5 + O2
oleoyl-CoA + ferricytochrome b5 + H2O
-
-
-
-
?
stearoyl-CoA + ferrocytochrome b5 + O2
oleoyl-CoA + ferricytochrome b5 + H2O
-
-
-
-
?
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
oleoyl-CoA + ferricytochrome b5 + H2O
-
-
-
?
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
oleoyl-CoA + ferricytochrome b5 + H2O
-
-
-
?
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
oleoyl-CoA + ferricytochrome b5 + H2O
rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, overview
-
-
?
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
oleoyl-CoA + ferricytochrome b5 + H2O
-
-
-
-
?
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
oleoyl-CoA + ferricytochrome b5 + H2O
-
-
-
?
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
oleoyl-CoA + ferricytochrome b5 + H2O
-
a key step in triglyceride synthesis in the fatty acid metabolic network
-
-
?
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
oleoyl-CoA + ferricytochrome b5 + H2O
-
rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, hepatic SCD1 activity may regulate fat accumulation in the liver and possibly protects from insulin resistance in obesity, overview
-
-
?
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
oleoyl-CoA + ferricytochrome b5 + H2O
-
rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, it is also involved in familial combined hyperlipidemia, fatty acid desaturation index, overview
-
-
?
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
oleoyl-CoA + ferricytochrome b5 + H2O
-
rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, which plays an important role in lipid metabolism and body weight control, overview
-
-
?
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
oleoyl-CoA + ferricytochrome b5 + H2O
-
stearoyl-CoA desaturase converts saturated to monounsaturated fatty acids and is a key enzyme in lipogenesis, elevated levels of endogenous lipogenesis increase the risk of fracture and suggest a role for saturated fat in the pathogenesis of osteoporosis
-
-
?
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
oleoyl-CoA + ferricytochrome b5 + H2O
-
the enzyme catalyzes the desaturation from saturated to monounsaturated fatty acids
-
-
?
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
oleoyl-CoA + ferricytochrome b5 + H2O
-
-
-
?
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
oleoyl-CoA + ferricytochrome b5 + H2O
rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, key enzyme in lipid metabolism and energy expenditure in mammals, overview
-
-
?
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
oleoyl-CoA + ferricytochrome b5 + H2O
-
-
-
-
?
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
oleoyl-CoA + ferricytochrome b5 + H2O
-
rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, deficiency of isozyme SCD1 leads to activation of the metabolic pathways that promote fatty acid beta-oxidation in mice, enzyme regulation in the heart in a hormone-dependent fashion, overview
-
-
?
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
oleoyl-CoA + ferricytochrome b5 + H2O
-
stearoyl-CoA desaturase 2 is uniquely and absolutely required for adipogenesis, SCD2 also controls the maintenance of adipocyte-specific gene expression in fully differentiated 3T3-L1 adipocytes, including the expression of SCD1, polysome profile analysis, overview
-
-
?
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
oleoyl-CoA + ferricytochrome b5 + H2O
-
essential enzyme activity, regulation mechanism, overview
-
-
?
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
oleoyl-CoA + ferricytochrome b5 + H2O
-
DesA3 expressed as a fusion with either a C-terminal His6 or c-myc tag has consistently higher activity and stability than native DesA3 having the native C-terminal sequence of LAA
-
-
?
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
oleoyl-CoA + ferricytochrome b5 + H2O
-
essential enzyme activity, regulation mechanism, overview
-
-
?
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
oleoyl-CoA + ferricytochrome b5 + H2O
-
DesA3 expressed as a fusion with either a C-terminal His6 or c-myc tag has consistently higher activity and stability than native DesA3 having the native C-terminal sequence of LAA
-
-
?
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
oleoyl-CoA + ferricytochrome b5 + H2O
-
-
-
-
?
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
oleoyl-CoA + ferricytochrome b5 + H2O
-
-
-
?
stearoyl-CoA + NAD(P)H + O2
oleoyl-CoA + NAD(P)+ + H2O
-
fatty acid desaturation
-
?
stearoyl-CoA + NADH + H+ + O2
oleoyl-CoA + NAD+ + H2O
-
-
-
-
?
stearoyl-CoA + NADH + H+ + O2
oleoyl-CoA + NAD+ + H2O
-
-
-
-
?
stearoyl-CoA + NADH + H+ + O2
oleoyl-CoA + NAD+ + H2O
-
-
-
-
?
stearoyl-CoA + NADH + O2
oleoyl-CoA + NAD+ + H2O
-
preferred substrate for SCD1
-
?
stearoyl-CoA + NADH + O2
oleoyl-CoA + NAD+ + H2O
-
Scd-/- and wild-type mice are fed with 20% high fat diets, fat-free basal mix is supplemented with 20% by weight of tristearin or triolein and 1% by weight corn oil
-
-
?
stearoyl-CoA + NADH + O2
oleoyl-CoA + NAD+ + H2O
-
maximal activity
-
?
stearoyl-CoA + NADH + O2
oleoyl-CoA + NAD+ + H2O
-
terminal component in the enzyme system
-
?
stearoyl-CoA + NADH + O2
oleoyl-CoA + NAD+ + H2O
-
terminal component in the enzyme system
-
?
additional information
?
-
-
preference for 18-carbon versus 16-carbon chain length fatty acids
-
-
?
additional information
?
-
-
Angus and Wagyu steers consuming high-roughage diets exhibit large differences in adipose tissue fatty acid composition, but there are no differences in terminal measures of CD activity or gene expression, overview
-
-
?
additional information
?
-
the enzyme also produces cis-9, trans-11 conjugated linoleic acid and palmitoleoyl-CoA
-
-
?
additional information
?
-
the enzyme also produces cis-9, trans-11 conjugated linoleic acid and palmitoleoyl-CoA
-
-
?
additional information
?
-
-
the enzyme also produces cis-9, trans-11 conjugated linoleic acid and palmitoleoyl-CoA
-
-
?
additional information
?
-
-
key enzyme in the synthesis of unsaturated fatty acyl-CoAs
-
-
?
additional information
?
-
-
incorporation of the first unsaturation bond into saturated fatty acids
-
-
?
additional information
?
-
heterologous expression in yeast shows that Dpu-DELTA9-KPSE produces E9 mono-unsaturated fatty acids of various chain lengths. When provided with the (7Z)-tetradec-7-enoate, it forms the (7Z,9E)-tetradec-7,9-dienoate unsaturated fatty acids, another biosynthetic intermediate that can be chain-shortened to (5Z,7Z)-dodeca-5,7-dienoate
-
-
?
additional information
?
-
heterologous expression in yeast shows that Dpu-DELTA9-KPSE produces E9 mono-unsaturated fatty acids of various chain lengths. When provided with the (7Z)-tetradec-7-enoate, it forms the (7Z,9E)-tetradec-7,9-dienoate unsaturated fatty acids, another biosynthetic intermediate that can be chain-shortened to (5Z,7Z)-dodeca-5,7-dienoate
-
-
?
additional information
?
-
heterologous expression in yeast shows that Dpu-DELTA9-KPSE produces E9 mono-unsaturated fatty acids of various chain lengths. When provided with the (7Z)-tetradec-7-enoate, it forms the (7Z,9E)-tetradec-7,9-dienoate unsaturated fatty acids, another biosynthetic intermediate that can be chain-shortened to (5Z,7Z)-dodeca-5,7-dienoate
-
-
?
additional information
?
-
heterologous expression in yeast shows that Dpu-DELTA9-KPSE produces E9 mono-unsaturated fatty acids of various chain lengths. When provided with the (7Z)-tetradec-7-enoate, it forms the (7Z,9E)-tetradec-7,9-dienoate unsaturated fatty acids, another biosynthetic intermediate that can be chain-shortened to (5Z,7Z)-dodeca-5,7-dienoate
-
-
?
additional information
?
-
heterologous expression in yeast shows that Dpu-DELTA9-KPSE produces E9 mono-unsaturated fatty acids of various chain lengths. When provided with the (7Z)-tetradec-7-enoate, it forms the (7Z,9E)-tetradec-7,9-dienoate unsaturated fatty acids, another biosynthetic intermediate that can be chain-shortened to (5Z,7Z)-dodeca-5,7-dienoate
-
-
?
additional information
?
-
-
heterologous expression in yeast shows that Dpu-DELTA9-KPSE produces E9 mono-unsaturated fatty acids of various chain lengths. When provided with the (7Z)-tetradec-7-enoate, it forms the (7Z,9E)-tetradec-7,9-dienoate unsaturated fatty acids, another biosynthetic intermediate that can be chain-shortened to (5Z,7Z)-dodeca-5,7-dienoate
-
-
?
additional information
?
-
-
fatty acid binding proteins my regulate the accessibility of fatty acids in the desaturation reaction to the active site
-
-
?
additional information
?
-
-
rate limiting-step in the cellular synthesis of monounsaturated fatty acids mainly oleate and palmitoleate
-
-
?
additional information
?
-
-
enzyme activity measured by conversion of 14C-stearic acid to 14C-oleic acid, reverse-phase HPLC
-
-
?
additional information
?
-
-
aging human orbitofrontal cortex includes decreasing of polyunsaturated fatty acid composition associates increases in lipogenic gene expression and stearoyl-CoA desaturase activity, overview
-
-
?
additional information
?
-
-
due to a population-based, longitudinal cohort study of men, the risk of fracture is highest among men with the highest levels of SCD activity index, overview
-
-
?
additional information
?
-
-
role of SCD1 in fatty acid metabolism in HepG2 cells, the desaturation systems in Hep-G2 cells are strongly compartmentalized, effects of SCD1 inhibition on fatty acid composition in HepG2 cells occur through changes in the dynamics of the fatty acid metabolic network and not through transcriptional regulatory mechanisms, overview
-
-
?
additional information
?
-
in addition to molecular oxygen, the SCD1 reaction requires NAD(P)H, cytochrome b5 reductase, and cytochrome b5 through which the electrons flow to SCD and then to molecular O2, which is reduced to H2O
-
-
?
additional information
?
-
in addition to molecular oxygen, the SCD1 reaction requires NAD(P)H, cytochrome b5 reductase, and cytochrome b5 through which the electrons flow to SCD and then to molecular O2, which is reduced to H2O
-
-
?
additional information
?
-
-
inhibition of the enzyme in cholesterol-fed hamsters leads to reduced overall body weight and adipose tissue deposition, while enzyme inhibition in absence of cholesterol does not. Enzyme inhibition induces hypercholesterinemia, overview
-
-
?
additional information
?
-
-
long-chain polyunsaturated fatty acid biosynthetic pathway
-
-
?
additional information
?
-
Mortierella alpina CBS 528.72 / ATCC 32222
-
long-chain polyunsaturated fatty acid biosynthetic pathway
-
-
?
additional information
?
-
-
SCD2 and SCD3 preferentially utilize palmitoyl-CoA
-
-
?
additional information
?
-
-
rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids
-
-
?
additional information
?
-
enzyme SCD1 catalyzes the formation of a cis-double bond between the 9th and 10th carbons of stearoyl- or palmitoyl-CoA. The reaction requires molecular oxygen, which is activated by a diiron center, and cytochrome b5, which regenerates the di-iron center
-
-
?
additional information
?
-
enzyme SCD1 catalyzes the formation of a cis-double bond between the 9th and 10th carbons of stearoyl- or palmitoyl-CoA. The reaction requires molecular oxygen, which is activated by a diiron center, and cytochrome b5, which regenerates the di-iron center
-
-
?
additional information
?
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enzyme SCD1 catalyzes the formation of a cis-double bond between the 9th and 10th carbons of stearoyl- or palmitoyl-CoA. The reaction requires molecular oxygen, which is activated by a diiron center, and cytochrome b5, which regenerates the di-iron center
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in addition to molecular oxygen, the SCD1 reaction requires NAD(P)H, cytochrome b5 reductase, and cytochrome b5 through which the electrons flow to SCD and then to molecular O2, which is reduced to H2O
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in addition to molecular oxygen, the SCD1 reaction requires NAD(P)H, cytochrome b5 reductase, and cytochrome b5 through which the electrons flow to SCD and then to molecular O2, which is reduced to H2O
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in addition to molecular oxygen, the SCD1 reaction requires NAD(P)H, cytochrome b5 reductase, and cytochrome b5 through which the electrons flow to SCD and then to molecular O2, which is reduced to H2O
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in addition to molecular oxygen, the SCD1 reaction requires NAD(P)H, cytochrome b5 reductase, and cytochrome b5 through which the electrons flow to SCD and then to molecular O2, which is reduced to H2O
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mouse SCD3 isoform preferentially catalyzes palmitoleate synthesis
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mouse SCD3 isoform preferentially catalyzes palmitoleate synthesis
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mouse SCD3 isoform preferentially catalyzes palmitoleate synthesis
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mouse SCD3 isoform preferentially catalyzes palmitoleate synthesis
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SCD1 catalyses the DELTA9 desaturation of 12-19 carbon saturated fatty acids to monounsaturated fatty acids
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wild-type isozyme SCD3 is an exclusive 16:0 desaturase, while SCD3 enzyme mutant I112A/E113L is also active with stearoyl-CoA
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wild-type isozyme SCD3 is an exclusive 16:0 desaturase, while SCD3 enzyme mutant I112A/E113L is also active with stearoyl-CoA
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wild-type isozyme SCD3 is an exclusive 16:0 desaturase, while SCD3 enzyme mutant I112A/E113L is also active with stearoyl-CoA
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DesA3 is a membrane-bound stearoyl-CoA desaturase that works together with oxidoreductase Rv3230c, encoded by gene rv3230c, to produce oleic acid, an 55 essential constituent of mycobacterial membrane phospholipids and triglycerides
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the enzyme reacts with oxidoreductase Rv3230c to produce oleic acid
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DesA3 is a membrane-bound stearoyl-CoA desaturase that works together with oxidoreductase Rv3230c, encoded by gene rv3230c, to produce oleic acid, an 55 essential constituent of mycobacterial membrane phospholipids and triglycerides
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the enzyme reacts with oxidoreductase Rv3230c to produce oleic acid
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glycerolipid such as phosphatidylcholine is involved as an intermediate substrate
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temperature-dependent chain length change is not mediated by a temperature-dependent change in desaturase substrate specificity
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not acyl-CoA as substrate but phospholipid
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biosynthesis of unsaturated fatty acids. Possible substrates: acyl-CoA, acyl-acyl-carrier and acyl chains of phospholipids. The substrate in vivo is saturated phospholipid
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12-19 carbon fatty acyl chains undergo 9,10 desaturation. Dephospho-, deamino- and (1-N6-etheno)-CoA analogs of stearoyl-CoA are poorer substrates than stearoyl-CoA
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specific for C14-C19 fatty acyl-CoA substrates
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key enzyme in the synthesis of unsaturated fatty acyl-CoAs
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decreased degradation of SCD is responsible for the increase in palmitoyl-CoA chain elongase activity in addition to increased transcription of SCD1 in the rats treated with clofibric acid, overview
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decreased degradation of SCD is responsible for the increase in palmitoyl-CoA chain elongase activity in addition to increased transcription of SCD1 in the rats treated with clofibric acid, overview
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12-19 carbon fatty acyl chains undergo 9,10 desaturation. Dephospho-, deamino- and (1-N6-etheno)-CoA analogs of stearoyl-CoA are poorer substrates than stearoyl-CoA
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