1.14.18.6: 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase

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For detailed information about 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase, go to the full flat file.

Reaction

Synonyms

FA2H, AtFAH1, FA2H, FAH1, fatty acid 2-hydroxylase, fatty acid 2-hydroxylase 1, fatty acid alpha-hydroxylase, SCS7, Scs7p, scScs7p, sphingolipid alpha-hydroxylase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.18.6 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase

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Results	in table
1	Activating Compound
3	AA Sequence
2	Application
5	Cloned(Commentary)
6	Cofactor
2	Crystallization (Commentary)
210	Disease/ Diagnostics
5	Expression
16	General Information
6	Localization
2	Metals/Ions
2	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
19	Organism
2	Pathway
18	Protein Variants
2	Purification (Commentary)
1	Reaction
19	Reference
14	Source Tissue
9	Substrates and Products (Substrate)
2	Subunits
24	Synonyms
1	Systematic Name

Cloned

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Cloned on EC 1.14.18.6 - 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

expressed in Saccharomyces cerevisiae strain BJ5460

Saccharomyces cerevisiae

Q03529

742884

expression in CHO cell

Homo sapiens

Q7L5A8

734433

expression in CHO cells

Mus musculus

Q5MPP0

733284

expression in HCT116 cells

Homo sapiens

Q7L5A8

733604

gene SCS7, recombinant overexpression of ZZ/His6/MBP-tagged wild-type scScs7p and DELTA95scScs7p from plasmid pSGP46 in Saccharomyces cerevisiae strain BJ5460, recombinant expression of point mutants in enzyme-deficient Saccharomyces cerevisiae strain

Saccharomyces cerevisiae

Q03529

742884