1.14.18.5: sphingolipid C4-monooxygenase
This is an abbreviated version!
For detailed information about sphingolipid C4-monooxygenase, go to the full flat file.
Word Map on EC 1.14.18.5
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1.14.18.5
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sphingolipids
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sphingoid
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phytosphingosine
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phytoceramide
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oxygen-dependent
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inositolphosphorylceramide
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c4-hydroxylation
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nidulans
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dihydrosphingosine
- 1.14.18.5
- sphingolipids
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sphingoid
- phytosphingosine
- phytoceramide
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oxygen-dependent
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inositolphosphorylceramide
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c4-hydroxylation
- nidulans
- dihydrosphingosine
Reaction
Synonyms
bifunctional sphingolipid D4-desaturase/C4-hydroxylase, DES2, DHS hydroxylase, dihydroceramide hydrolase, dihydroceramide hydroxylase, EC 1.14.13.169, LmjF_26_1670, SBH1, SBH2, SC4H, sphinganine C4-hydroxylase, sphinganine C4-monooxygenase, sphingolipid C4-hydroxylase, sphingolipid delta(4)-desaturase/C4-monooxygenase, sphingolipid hydroxylase, SUR2, Sur2p, SYR2, Syr2p
ECTree
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Reference on EC 1.14.18.5 - sphingolipid C4-monooxygenase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sperling, P.; Ternes, P.; Moll, H.; Franke, S.; Zaehringer, U.; Heinz, E.
Functional characterization of sphingolipid C4-hydroxylase genes from Arabidopsis thaliana
FEBS Lett.
494
90-94
2001
Arabidopsis thaliana (Q9AST3), Arabidopsis thaliana
Mizutani, Y.; Kihara, A.; Igarashi, Y.
Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation
FEBS Lett.
563
93-97
2004
Homo sapiens (Q6QHC5), Homo sapiens
Idkowiak-Baldys, J.; Grilley, M.; Takemoto, J.
Sphingolipid C4 hydroxylation influences properties of yeast detergent-insoluble glycolipid-enriched membranes
FEBS Lett.
569
272-276
2004
Saccharomyces cerevisiae
Haak, D.; Gable, K.; Beeler, T.; Dunn, T.
Hydroxylation of Saccharomyces cerevisiae ceramides requires Sur2p and Scs7p
J. Biol. Chem.
272
29704-29710
1997
Saccharomyces cerevisiae
Grilley, M.; Stock, S.; Dickson, R.; Lester, R.; Takemoto, J.
Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation in Saccharomyces cerevisiae
J. Biol. Chem.
273
11062-11068
1998
Saccharomyces cerevisiae, Saccharomyces cerevisiae W303C
Moreno-Perez, A.J.; Martinez-Force, E.; Garces, R.; Salas, J.J.
Sphingolipid base modifying enzymes in sunflower (Helianthus annuus): cloning and characterization of a C4-hydroxylase gene and a new paralogous DELTA8-desaturase gene
J. Plant Physiol.
168
831-839
2011
Helianthus annuus
Bae, J.H.; Sohn, J.H.; Park, C.S.; Rhee, J.S.; Choi, E.S.
Cloning and functional characterization of the SUR2/SYR2 gene encoding sphinganine hydroxylase in Pichia ciferrii
Yeast
21
437-443
2004
Wickerhamomyces ciferrii (Q6YGT5), Wickerhamomyces ciferrii
Wright, B.S.; Snow, J.W.; OBrien, T.C.; Lynch, D.V.
Synthesis of 4-hydroxysphinganine and characterization of sphinganine hydroxylase activity in corn
Arch. Biochem. Biophys.
415
184-192
2003
Zea mays
Idkowiak-Baldys, J.; Takemoto, J.Y.; Grilley, M.M.
Structure-function studies of yeast C-4 sphingolipid long chain base hydroxylase
Biochim. Biophys. Acta
1618
17-24
2003
Saccharomyces cerevisiae (P38992), Saccharomyces cerevisiae
Ternes, P.; Franke, S.; Zaehringer, U.; Sperling, P.; Heinz, E.
Identification and characterization of a sphingolipid delta 4-desaturase family
J. Biol. Chem.
277
25512-25518
2002
Mus musculus (Q8R2F2)
Vacchina, P.; Tripodi, K.E.; Escalante, A.M.; Uttaro, A.D.
Characterization of bifunctional sphingolipid DELTA4-desaturases/C4-hydroxylases of trypanosomatids by liquid chromatography-electrospray tandem mass spectrometry
Mol. Biochem. Parasitol.
184
29-38
2012
Leishmania major (G3FCJ2)
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