1.14.18.2: CMP-N-acetylneuraminate monooxygenase

This is an abbreviated version!
For detailed information about CMP-N-acetylneuraminate monooxygenase, go to the full flat file.

Reaction

Synonyms

CMAH, CMP Neu5Ac hydroxylase, CMP-N-acetylneuraminate hydroxylase, CMP-N-acetylneuraminate,NAD(P)H:oxygen oxidoreductase (hydroxylating), CMP-N-acetylneuraminic acid hydroxylase, CMP-Neu5Ac hydroxylase, CMP-NeuAc hydroxylase, cytidine monophosphate-N-acetylneuraminic acid hydroxylase, cytidine monophospho-N-acetylneuraminic acid hydroxylase, EC 1.14.13.45, oxygenase, cytidine monophosphoacetylneuraminate mono-, pcmah

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.18.2 CMP-N-acetylneuraminate monooxygenase

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Results	in table
11	Activating Compound
710	AA Sequence
3	Application
1	CAS Registry Number
14	Cloned(Commentary)
30	Cofactor
37	Disease/ Diagnostics
12	General Information
4	General Stability
52	Inhibitors
12	KM Value [mM]
18	Localization
10	Metals/Ions
9	Molecular Weight [Da]
19	Natural Substrates/ Products (Substrates)
53	Organism
2	Pathway
6	pH Optimum
1	pH Range
1	Posttranslational Modification
16	Protein Variants
8	Purification (Commentary)
1	Reaction
5	Reaction Type
53	Reference
62	Source Tissue
4	Specific Activity [micromol/min/mg]
4	Storage Stability
47	Substrates and Products (Substrate)
5	Subunits
31	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]

Inhibitors

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Inhibitors on EC 1.14.18.2 - CMP-N-acetylneuraminate monooxygenase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

1,10-phenanthroline

5 entries

2,2'-dipyridyl

2 entries

3'-AMP

Sus scrofa

-

5 mM, complete inhibition

639316

3'-CMP

Sus scrofa

-

5 mM, about 20% inhibition

639316

3'-UMP

Sus scrofa

-

5 mM, about 90% inhibition

639316

5'-AMP

Sus scrofa

-

5 mM, about 78% inhibition

639316

5'-UMP

Sus scrofa

-

5 mM, about 15% inhibition

639316

anti-(rat cytochrome b5) antiserum

2 entries

-

azide

Asterias rubens

-

-

639325

Ca2+

Asterias rubens

-

0.5 mM, 12% inhibition

639325

cardiolipin

Mus musculus

-

3 mM, 15% inhibition

639334

CHAPS

Asterias rubens

-

15 mM, complete inhibition

639325

cholic acid

Asterias rubens

-

10 mM, 89% inhibition

639325

CMP-N-glycoloylneuraminate

Mus musculus

-

-

639334

Co2+

Mus musculus

-

-

639314

Cu2+

Mus musculus

-

-

639314

decylglucopyranoside

Asterias rubens

-

5 mM, 22% inhibition

639325

EDTA

Mus musculus

-

-

639314, 639324

ferrozine

5 entries

Hg2+

Asterias rubens

-

slight inhibition

639325

KCN

4 entries

Mg2+

Mus musculus

-

-

639314

Mn2+

2 entries

Na2HPO4

Mus musculus

-

2 mM, 86% inhibition

639334

Na4P2O7

Mus musculus

-

2 mM, 54% loss of activity

639334

NaCl

Asterias rubens

-

above 100 mM

639331

Ni2+

Mus musculus

-

-

639314

octylglucopyranoside

Asterias rubens

-

30 mM, 48% inhibition

639325

phosphatidic acid

Mus musculus

-

3 mM, 20% inhibition

639334

phosphatidylinositol

Mus musculus

-

3 mM, 68% inhibition

639334

Tiron

3 entries

Zn2+

Mus musculus

-

-

639314

Zwittergent 3-12

Asterias rubens

-

5 mM, 40% inhibition

639325

additional information

Asterias rubens

-

not inhibited by increased ionic strength, no inhibition by 1 M NaCl

639325

-

1,10-phenanthroline

Asterias rubens

-

-

639325

1,10-phenanthroline

Asterias rubens

-

2 mM, 88% inhibition

639331

1,10-phenanthroline

Asterias rubens

-

-

639332

1,10-phenanthroline

Mus musculus

-

5 mM, complete inhibition

639334

1,10-phenanthroline

Sus scrofa

-

-

639333

2,2'-dipyridyl

Asterias rubens

-

2 mM, 27% inhibition

639331

2,2'-dipyridyl

Asterias rubens

-

-

639332

anti-(rat cytochrome b5) antiserum

Mus musculus

-

-

639319, 639334

-

anti-(rat cytochrome b5) antiserum

Sus scrofa

-

-

639319

-

ferrozine

Asterias rubens

-

-

639325

ferrozine

Asterias rubens

-

2 mM, 83% inhibition

639331

ferrozine

Asterias rubens

-

-

639332

ferrozine

Mus musculus

-

0.7 mM, 82% inhibition

639334

ferrozine

Sus scrofa

-

-

639333

KCN

Asterias rubens

-

-

639325

KCN

Asterias rubens

-

2 mM, 80% inhibition

639331

KCN

Mus musculus

-

5 mM, 49% inhibition

639334

KCN

Sus scrofa

-

-

639333

Mn2+

Asterias rubens

-

0.5 mM, slight inhibition

639325

Mn2+

Mus musculus

-

-

639314

Tiron

Asterias rubens

-

-

639325

Tiron

Mus musculus

-

5 mM, 82% inhibition

639334

Tiron

Sus scrofa

-

-

639333