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1.14.17.3: peptidylglycine monooxygenase

This is an abbreviated version!
For detailed information about peptidylglycine monooxygenase, go to the full flat file.

Word Map on EC 1.14.17.3

Reaction

[peptide]-glycine
+ 2 ascorbate +
O2
=
[peptide]-(2S)-2-hydroxyglycine
+ 2 monodehydroascorbate +
H2O

Synonyms

alpha-AE, bifunctional PAM, bifunctional peptidylglycine alpha-amidating monooxygenase, CG3832, hPHMcc, More, PAM, PAM-1, PAM-2, PAM-A, PAM-B, PAM/PHM, peptide alpha-amidating enzyme, peptide alpha-amide synthase, peptide-alpha-amide synthetase, peptidyl alpha-amidating enzyme, peptidyl alpha-hydroxylating monooxygenase, peptidyl-glycine alpha-amidating monooxygenase, peptidylglycine 2-hydroxylase, peptidylglycine alpha-amidating mono-oxygenase, peptidylglycine alpha-amidating monooxygenase, peptidylglycine alpha-hydroxylase, peptidylglycine alpha-hydroxylating monooxygenase, peptidylglycine alpha-hydroxylating-monooxygenase, peptidylglycine alpha-monooxygenase, peptidylglycine monooxygenase, peptidylglycine-alpha-amidating monooxygenase, PHM, PHMcc, synthase, peptide alpha-amide, type A PAM

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.17 With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.17.3 peptidylglycine monooxygenase

KM Value

KM Value on EC 1.14.17.3 - peptidylglycine monooxygenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
19
2,6-difluorohippuric acid
apparent KM
1.4
2-aminohippuric acid
apparent KM
0.86
2-hydroxyhippuric acid
apparent KM
3.4
2-iodohippuric acid
apparent KM
4.3
2-methylhippuric acid
apparent KM
0.22
2-propylmercaptoacetylglycine
apparent KM
0.036
2-pyridylmercaptoacetylglycine
apparent KM
1.2
3-(2-furyl)acryloylglycine
apparent KM
2.2
3-chlorohippuric acid
apparent KM
0.3
3-indolylacetylglycine
apparent KM
1.4
3-methylhippuric acid
apparent KM
0.038
3-phenylthiopropionylglycine
apparent KM
2.6
4-aminohippuric acid
apparent KM
0.52
4-bromohippuric acid
apparent KM
0.62
4-chlorohippuric acid
apparent KM
1.2
4-ethylhippuric acid
apparent KM
1.7
4-hydroxyhippuric acid
apparent KM
0.82
4-methoxyhippuric acid
apparent KM
1.8
4-methylhippuric acid
apparent KM
0.11
4-nitrobenzoyl-Gly-Gly
apparent KM
0.47
4-nitrohippuric acid
apparent KM
0.16
4-phenylbutyrylglycine
apparent KM
1.2
4-propylhippuric acid
apparent KM
0.77
4-trifluoromethylhippuric acid
apparent KM
0.15
5-phenylpentanoylglycine
apparent KM
0.051
6-phenylhexanoylglycine
apparent KM
0.1
8-phenyloctanoylglycine
apparent KM
1400
acetyl-D-alanine
apparent KM
1.5
acetyl-Gly-Gly
apparent KM
0.00035 - 1.39
acetyl-L-Tyr-L-Phe-Gly
-
0.2
alanyl-L-phenylalanylglycine
-
pH and temperature not specified in the publication
4
alanyl-L-prolylglycine
-
pH and temperature not specified in the publication
0.035
alanylglycyl-L-phenylalanylglycine
-
pH and temperature not specified in the publication
3
alanylglycyl-L-prolylglycine
-
pH and temperature not specified in the publication
0.018
alanylglycylvalyl-L-phenylalanylglycine
-
pH and temperature not specified in the publication
0.96
alanylglycylvalyl-L-prolylglycine
-
pH and temperature not specified in the publication
0.292
alpha-hydroxyhippuric acid
-
0.4 mM ferrocyanide, 100 mM MES pH 6.0, 30 mM KCl, 1 microM CuSO4
84
benzoyl-D-alanine
apparent KM
35
CBZ-D-alanine
apparent KM
0.59
CBZ-glycine
apparent KM
0.42
chloroacetyl-Gly-Gly
apparent KM
0.23
cinnamoylglycine
apparent KM
0.033 - 0.289
D-Tyr-Pro-Gly-Gly
0.007 - 0.22
D-Tyr-Val-Gly
0.022 - 0.143
dabsyl-Gly-Phe-Gly
0.00091 - 0.8
dansyl-D-Tyr-Val-Gly
0.0033 - 0.0194
dansyl-L-Tyr-L-Val-Gly
0.003
dansyl-Tyr-Val-Gly
-
recombinant enzyme
0.03 - 0.26
ferrocyanide
2.1
gamma-Glu-Gly-Gly
-
pH 6.0, 37°C
0.13
glutathione
-
pH 6.0, 37°C
2.78
H2O2
-
100 mM MES, pH 5.5, 0.2 mM dansyl-D-Tyr-Val-Gly, 5 microM CuSO4, H2O2
0.61 - 1.3
hippuric acid
0.078
hippuryl-Gly
apparent KM
0.31
hippuryl-Gly-Gly
apparent KM
0.94
hydrocinnamoylglycine
apparent KM
0.28
isocaproylglycine
apparent KM
0.28
L-ascorbate
-
+ 0.02 mM N-dansyl-Tyr-Phe-Gly
6.5
L-phenylalanylglycine
-
pH and temperature not specified in the publication
0.88
L-prolylglycine
-
pH and temperature not specified in the publication
0.31
L-pyroglutamyl-Gly
apparent KM
0.035
leukotriene C4
-
pH 6.0, 37°C
2.7
N-(2-furoyl)glycine
apparent KM
1.6
N-(2-thienylcarbonyl)glycine
apparent KM
0.011
N-(4-amino-6-methyl-3-oxoheptanoyl)-L-phenylalanylglycine
-
pH and temperature not specified in the publication
0.86
N-(4-amino-6-methyl-3-oxoheptanoyl)glycylglycine
-
pH and temperature not specified in the publication
4.1
N-(alpha-methylhydrocinnamoyl)glycine
apparent KM
0.16 - 0.33
N-(Phenylacetyl)glycine
0.12
N-acetyl-Arg-Gly-Gly
-
100 mM MES/NaOH, pH 6.0, 30 mM NaCl, 1% (v/v) ethanol, 0.001% (v/v) Triton X-100, 1 microM Cu(NO3)2, 10 mg/l catalase, 6 mM ascorbate, 8 microM N-dansyl-Tyr-Val-Gly
0.02
N-acetyl-Gln-Lys-Glu-Ser-Thr-Leu-His-Leu-Val-Leu-Arg-Leu-Arg-Gly-Gly
-
100 mM MES/NaOH, pH 6.0, 30 mM NaCl, 1% (v/v) ethanol, 0.001% (v/v) Triton X-100, 1 microM Cu(NO3)2, 10 mg/l catalase, 6 mM ascorbate, 8 microM N-dansyl-Tyr-Val-Gly
0.0079
N-acetyl-L-Phe-Gly
-
pH not specified in the publication, temperature not specified in the publication
0.015 - 0.016
N-acetyl-L-phenylalanylglycine
0.13
N-acetyl-Leu-Arg-Gly-Gly
-
100 mM MES/NaOH, pH 6.0, 30 mM NaCl, 1% (v/v) ethanol, 0.001% (v/v) Triton X-100, 1 microM Cu(NO3)2, 10 mg/l catalase, 6 mM ascorbate, 8 microM N-dansyl-Tyr-Val-Gly
0.024
N-acetyl-Leu-Arg-Leu-Arg-Gly-Gly
-
100 mM MES/NaOH, pH 6.0, 30 mM NaCl, 1% (v/v) ethanol, 0.001% (v/v) Triton X-100, 1 microM Cu(NO3)2, 10 mg/l catalase, 6 mM ascorbate, 8 microM N-dansyl-Tyr-Val-Gly
0.018
N-acetyl-Leu-His-Leu-Val-Leu-Arg-Leu-Arg-Gly-Gly
-
100 mM MES/NaOH, pH 6.0, 30 mM NaCl, 1% (v/v) ethanol, 0.001% (v/v) Triton X-100, 1 microM Cu(NO3)2, 10 mg/l catalase, 6 mM ascorbate, 8 microM N-dansyl-Tyr-Val-Gly
0.0012 - 0.0098
N-acetyl-Tyr-Val-Gly
9.3 - 18
N-acetylglycine
1.2
N-acetylglycylglycine
-
pH and temperature not specified in the publication
1.3
N-benzoylglycine
-
-
2.3
N-butyrylglycine
-
pH 6.0, 37°C
0.0025
N-Dan-Tyr-Val-Gly
-
PHM activity in the soluble fraction of control and intermittent hypoxia brain stem ectracts
3.5 - 4.5
N-dansyl-L-Tyr-L-Phe-Gly
-
0.0032
N-dansyl-Tyr-Phe-Gly
-
+ 2 mM L-ascorbate
0.031
N-dansyl-Tyr-Val-D-Ala
apparent KM
0.0077
N-dansyl-Tyr-Val-Gly
pH 6.5, 37°C
0.1 - 0.2
N-decanoylglycine
0.42 - 0.58
N-hexanoylglycine
0.2
N-octanoylglycine
-
pH 6.0, 37°C
2.4
N-propionylglycine
-
pH 6.0, 37°C
4.1
N-trifluoroacetylglycine
-
-
0.0011
N-trinitrophenyl-D-Tyr-Val-Gly
-
pH 6.0, 37°C, recombinant enzyme
0.9
N-[(2-phenylcyclopropyl)carbonyl]glycine
apparent KM
0.059
N-[(benzylmercapto)carbonyl]glycine
apparent KM
0.007
N-[3-(1-leucylpyrrolidin-2-yl)-3-oxopropanoyl]-L-phenylalanylglycine
-
pH and temperature not specified in the publication
0.55
N-[3-(1-leucylpyrrolidin-2-yl)-3-oxopropanoyl]glycylglycine
-
pH and temperature not specified in the publication
1.9
nicotinuric acid
apparent KM
0.17
O-acetyl-L-mandelyl-Gly
-
pH not specified in the publication, temperature not specified in the publication
0.1 - 658.1
O2
0.009 - 0.018
peptidylglycine
0.36
phenylhydantoic acid
apparent KM
0.19
phenylmercaptoacetylglycine
apparent KM
0.024
phenylthioacetylglycine
apparent KM
1.1
S-(1,2-dicarboxyethyl)-glutathione
-
pH 6.0, 37°C
0.027
S-(4-nitrobenzyl)-glutathione
-
pH 6.0, 37°C
0.067
S-butyl-glutathione
-
pH 6.0, 37°C
0.016
S-decyl-glutathione
-
pH 6.0, 37°C
0.23
S-ethyl-glutathione
-
pH 6.0, 37°C
0.035
S-hexyl-glutathione
-
pH 6.0, 37°C
0.27
S-methyl-glutathione
-
pH 6.0, 37°C
0.032
S-octyl-glutathione
-
pH 6.0, 37°C
0.11
S-propyl-glutathione
-
pH 6.0, 37°C
3.7
tBOC-Gly
apparent KM
0.3
tBOC-Gly-Gly
apparent KM
0.0044 - 0.0068
Trinitrophenyl-D-Tyr-Val-Gly
0.6
ubiquitin
-
100 mM MES/NaOH, pH 6.0, 30 mM NaCl, 1% (v/v) ethanol, 0.001% (v/v) Triton X-100, 1 microM Cu(NO3)2, 10 mg/l catalase, 6 mM ascorbate, 8 microM N-dansyl-Tyr-Val-Gly
additional information
additional information
-