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1.14.17.3: peptidylglycine monooxygenase

This is an abbreviated version!
For detailed information about peptidylglycine monooxygenase, go to the full flat file.

Word Map on EC 1.14.17.3

Reaction

[peptide]-glycine
+ 2 ascorbate +
O2
=
[peptide]-(2S)-2-hydroxyglycine
+ 2 monodehydroascorbate +
H2O

Synonyms

alpha-AE, bifunctional PAM, bifunctional peptidylglycine alpha-amidating monooxygenase, CG3832, hPHMcc, More, PAM, PAM-1, PAM-2, PAM-A, PAM-B, PAM/PHM, peptide alpha-amidating enzyme, peptide alpha-amide synthase, peptide-alpha-amide synthetase, peptidyl alpha-amidating enzyme, peptidyl alpha-hydroxylating monooxygenase, peptidyl-glycine alpha-amidating monooxygenase, peptidylglycine 2-hydroxylase, peptidylglycine alpha-amidating mono-oxygenase, peptidylglycine alpha-amidating monooxygenase, peptidylglycine alpha-hydroxylase, peptidylglycine alpha-hydroxylating monooxygenase, peptidylglycine alpha-hydroxylating-monooxygenase, peptidylglycine alpha-monooxygenase, peptidylglycine monooxygenase, peptidylglycine-alpha-amidating monooxygenase, PHM, PHMcc, synthase, peptide alpha-amide, type A PAM

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.17 With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.17.3 peptidylglycine monooxygenase

Inhibitors

Inhibitors on EC 1.14.17.3 - peptidylglycine monooxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2E)-4-oxo-4-phenylbut-2-enoic acid
-
-
(3E)-4-(4-methoxyphenyl)but-3-enoic acid
-
-
(3E)-4-(4-methylphenyl)but-3-enoic acid
-
-
(3E)-4-[3-(benzyloxy)-4-methoxyphenyl]but-3-enoic acid
-
-
(3E)-4-[4-(benzyloxy)phenyl]but-3-enoic acid
-
-
(acetyloxy)acetic acid
-
-
(CBZ-hydrazido)glycine
-
(decanoylsulfanyl)acetic acid
-
-
(dodecanoyloxy)acetic acid
-
-
(E)-(4-dimethylamino)cinnamic acid
-
(E)-3,4-methylenedioxycinnamic acid
-
(E)-4-aminocinnamic acid
-
(nicotinamidomethyl)phosphonic acid
-
(R)-5-acetamido-4-oxo-6-phenyl-2-hexenoic acid
-
reversible and irreversible inhibition
(S)-5-acetamido-4-oxo-6-phenyl-2-hexenoic acid
-
reversible and irreversible inhibition
(S)-5-acetamido-7-methylthio-4-oxo-2-heptenoic acid
-
reversible and irreversible inhibition
(S)-N-CBZ-4-amino-2-hydroxybutyric acid
-
([(2S)-2-[(2-aminopropanoyl)amino]-3-phenylpropanoyl]oxy)acetic acid
-
-
([N-[3-(1-leucylpyrrolidin-2-yl)-3-oxopropanoyl]-L-phenylalanyl]oxy)acetic acid
-
-
([N-[3-(1-leucylpyrrolidin-2-yl)-3-oxopropanoyl]glycyl]oxy)acetic acid
-
-
([[(2S)-1-(2-aminopropanoyl)pyrrolidin-2-yl]carbonyl]oxy)acetic acid
-
-
([[(2S)-1-[[(2-aminopropanoyl)amino]acetyl]pyrrolidin-2-yl]carbonyl]oxy)acetic acid
-
-
([[(4-amino-6-methyl-3-oxoheptanoyl)amino]acetyl]oxy)acetic acid
-
-
2-trifluoromethylcinnamic acid
3,4-methylenedioxycinnamic acid
-
3-(3-pyridyl)acrylic acid
3-benzoylpropionic acid
-
4-aminocinnamic acid
-
4-nitrocinnamic acid
-
4-Phenyl-3-butenoic acid
4-phenyl-3-butenoic acid methyl ester
-
at 0.01 mg/ml inhibition in vivo of proliferation of Ras-transformed WB rat liver epithelial cells, inhibitor leads to increased gap junction communication in the WB-Ras cells, overview
4-phenylbut-3-enoic acid
-
PBA
5-(acetylamino)-4-oxo-6-phenyl-2-hexenoic acid
-
-
5-(acetylamino)-4-oxo-6-phenyl-2-hexenoic acid methyl ester
-
-
6-O-palmitoyl-L-ascorbate
-
acetyl-D-Leu-OCH2COOH
-
-
acetyl-D-Phe-Gly
-
-
acetyl-D-Phe-OCH2COOH
-
-
acetyl-DL-Phe-OCH2COOH
-
-
acetyl-Gly-OCH2COOH
-
-
acetyl-L-Leu-OCH2COOH
-
-
acetyl-L-Phe-D-Phe-Gly
-
-
acetyl-L-Phe-Gly
-
only substrate for alpha-hydroxylation
acetyl-L-Phe-OCH2COOH
-
-
adrenocorticotrophic hormone(1-10)
-
-
alpha-N-acetyl-adrenocorticotrophic hormone(1-14)
-
-
ascorbate
-
above 0.4 mM for the purified enzyme, above 1.5 mM for the enzyme in crude extract
Cinnamic acid
Cu2+
-
at higher concentration
D-Tyr-Pro-Gly-Gly
-
inhibition of activity with D-Tyr-Val-Gly
D-Tyr-Val-Gly
decanoyloxyacetic acid
-
-
diethyldithiocarbamate
Disulfiram
-
-
dithiothreitol
-
-
endorphin(51-61)NH2
-
i.e. pro-adrenocorticotrophic hormone(1-10)
-
endorphins
-
and proendorphins
-
ferrocyanide
-
inhibiting above 0.6 mM
gamma-keto acid
-
-
-
glutathione ethyl ester
-
glycolate
-
-
Glyoxylate 2-pyridylhydrazone
-
-
Glyoxylate 4-carboxyphenylhydrazone
-
-
Glyoxylate benzylhydrazone
-
-
glyoxylate phenylhydrazone
-
strongly
Glyoxylate phenylsemicarbazone
-
-
Glyoxylate phenylthiosemicarbazone
-
-
Glyoxylate semicarbazone
-
-
glyoxylate thiosemicarbazone
-
-
glyoxylate-N-hexyl-4-carbamoylphenylhydrazone
-
strongly
hippuric acid
-
-
imidazole
-
-
Monoethyl fumarate
-
mechanism-based inhibition
N,N-dimethyl-4-aminocinnamic acid
-
N,S-dibenzoyl-L-cysteine
-
N-(benzoyl)-D-serine
-
N-(thiobenzoyl)-(D,L)-alanine
-
N-acetyl-D-Leu-OCH2COOH
-
competitive inhibitor
N-acetyl-D-Phe-Gly
-
-
N-acetyl-L-Leu-OCH2COOH
-
competitive inhibitor
N-acetyl-L-Phe-OCH2COOH
-
competitive inhibitor
N-benzylglycine
-
N-Carboxymethyl N'-phenylhydrazone
-
weak inhibition
N-dansyl-4-aminocinnamate
a fluorescent molecule, an inactivator
N-dansyl-4-aminocinnamic acid
-
N-phenylthiohydantoic acid
-
NaN3
-
-
O-(phenylcarbamoyl)glycolic acid
-
O-acetyl-D-mandelyl-Gly
-
-
O-benzamidoglycolic acid
-
p-hydroxymercuribenzoate
-
slightly
peptides
-
especially those with COOH-terminal glycine residues
perdeuterated cinnamic acid
phenylpropionic acid
-
phenylpropynoic acid
i.e. phenylpropiolic acid
phosphate
-
-
Pro-Leu-Gly hydroxamic acid
-
S-(2-phenylthioacetyl)thioglycolic acid
S-(3-phenylthiopropionyl)thioglycolic acid
S-(4-methylthiobenzoyl)thioglycolic acid
S-(4-methylthiobenzoyl)thioglycolic acid ethyl ester
-
S-(phenylthiocarbamoyl)-3-mercaptopropionic acid
S-(phenylthiocarbamoyl)thioglycolic acid
S-(thiobenzoyl)-(R,S)-thiolactic acid
-
S-(thiobenzoyl)-4-mercapto-4-cyanopentanoic acid
-
S-(thiobenzoyl)thioglycolic acid
S-(thiolauroyl)thioglycolic acid
-
S-phenylmercaptoacetic acid
Salicylhydroxamic acid
-
sulfite
-
irreversible inactivation is Cu2+-dependent
trans-Benzoylacrylic acid
-
mechanism-based inhibition
trans-cinnamic acid
-
Urocanic acid
[(1R,2S)-2-phenylcyclopropyl]acetic acid
-
-
[(4-Methoxybenzoyl)oxy]acetic acid
-
-
[(phenylacetyl)oxy]acetic acid
-
-
[(phenylacetyl)sulfanyl]acetic acid
-
-
[[(2S)-2-(acetylamino)-3-phenylpropanoyl]oxy]acetic acid
-
-
[[(2S)-2-(acetylamino)-3-phenylpropanoyl]sulfanyl]acetic acid
-
-
[[(2S)-2-([[(2-aminopropanoyl)amino]acetyl]amino)-3-phenylpropanoyl]oxy]acetic acid
-
-
[[(2S)-2-amino-3-phenylpropanoyl]oxy]acetic acid
-
-
[[(2S)-pyrrolidin-2-ylcarbonyl]oxy]acetic acid
-
-
[[(acetylamino)acetyl]oxy]acetic acid
-
-
[[N-(4-amino-6-methyl-3-oxoheptanoyl)-L-phenylalanyl]oxy]acetic acid
-
-
additional information
-