1.14.17.3: peptidylglycine monooxygenase

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For detailed information about peptidylglycine monooxygenase, go to the full flat file.

Reaction

Synonyms

alpha-AE, bifunctional PAM, bifunctional peptidylglycine alpha-amidating monooxygenase, CG3832, hPHMcc, More, PAM, PAM-1, PAM-2, PAM-A, PAM-B, PAM/PHM, peptide alpha-amidating enzyme, peptide alpha-amide synthase, peptide-alpha-amide synthetase, peptidyl alpha-amidating enzyme, peptidyl alpha-hydroxylating monooxygenase, peptidyl-glycine alpha-amidating monooxygenase, peptidylglycine 2-hydroxylase, peptidylglycine alpha-amidating mono-oxygenase, peptidylglycine alpha-amidating monooxygenase, peptidylglycine alpha-hydroxylase, peptidylglycine alpha-hydroxylating monooxygenase, peptidylglycine alpha-hydroxylating-monooxygenase, peptidylglycine alpha-monooxygenase, peptidylglycine monooxygenase, peptidylglycine-alpha-amidating monooxygenase, PHM, PHMcc, synthase, peptide alpha-amide, type A PAM

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.17 With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.17.3 peptidylglycine monooxygenase

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Results	in table
6	Activating Compound
644	AA Sequence
9	Application
1	CAS Registry Number
43	Cloned(Commentary)
70	Cofactor
2	Crystallization (Commentary)
24	Disease/ Diagnostics
1	Expression
24	General Information
4	General Stability
24	IC50 Value
162	Inhibitors
1	kcat/KM [mM/s]
79	Ki Value [mM]
168	KM Value [mM]
43	Localization
81	Metals/Ions
37	Molecular Weight [Da]
83	Natural Substrates/ Products (Substrates)
101	Organism
3	Oxidation Stability
31	PDB ID
48	pH Optimum
5	pH Range
1	pH Stability
2	Posttranslational Modification
47	Protein Variants
44	Purification (Commentary)
30	Reaction
29	Reaction Type
99	Reference
116	Source Tissue
52	Specific Activity [micromol/min/mg]
372	Substrates and Products (Substrate)
19	Subunits
193	Synonyms
1	Systematic Name
31	Temperature Optimum [°C]
1	Temperature Stability [°C]
30	Turnover Number [1/s]

Disease

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Disease on EC 1.14.17.3 - peptidylglycine monooxygenase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Carcinogenesis

Probing the peptidylglycine alpha-hydroxylating monooxygenase active site with novel 4-phenyl-3-butenoic acid based inhibitors.

20715282

Dementia

Alzheimer's disease: low levels of peptide alpha-amidation activity in brain and CSF.

3587629

Infections

Comparative study of Helicobacter pylori eradication rates of concomitant therapy vs modified quadruple therapy comprising proton-pump inhibitor, bismuth, amoxicillin, and metronidazole in Korea.

29369454

Neoplasms

Autocrine growth loops dependent on peptidyl alpha-amidating enzyme as targets for novel tumor cell growth inhibitors.

10413197

Neoplasms

Molecular profile of androgen-independent prostate cancer xenograft LuCaP 23.1.

16043352

Neoplasms

Probing the peptidylglycine alpha-hydroxylating monooxygenase active site with novel 4-phenyl-3-butenoic acid based inhibitors.

20715282

Neoplasms

Secretion and regulation of two biosynthetic enzyme activities, peptidyl-glycine alpha-amidating monooxygenase and a carboxypeptidase, by mouse pituitary corticotropic tumor cells.

6092033

Thyroid Neoplasms

Human peptidylglycine alpha-amidating monooxygenase: cDNA, cloning and functional expression of a truncated form in COS cells.

2357221

Thyroid Neoplasms

Multiple forms of peptidyl alpha-amidating enzyme: purification from rat medullary thyroid carcinoma CA-77 cell-conditioned medium.

2721443

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