1.14.16.7: phenylalanine 3-monooxygenase

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For detailed information about phenylalanine 3-monooxygenase, go to the full flat file.

Reaction

Synonyms

PacX, phenylalanine 3-hydroxylase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.16.7 phenylalanine 3-monooxygenase

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Systematic Name

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Systematic Name on EC 1.14.16.7 - phenylalanine 3-monooxygenase

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SYSTEMATIC NAME

IUBMB Comments

L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)

The enzyme, characterized from the bacterium Streptomyces coeruleorubidus, forms 3-hydroxy-L-phenylalanine (i.e. m-L-tyrosine), which is one of the building blocks in the biosynthesis of the uridyl peptide antibiotics pacidamycins. The 4a-hydroxytetrahydropteridine formed can dehydrate to 6,7-dihydropteridine, both spontaneously and by the action of EC 4.2.1.96, 4a-hydroxytetrahydrobiopterin dehydratase. The 6,7-dihydropteridine must be enzymically reduced back to tetrahydropteridine, by EC 1.5.1.34, 6,7-dihydropteridine reductase, before it slowly rearranges into the more stable but inactive compound 7,8-dihydropteridine.