Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.14.16.4: tryptophan 5-monooxygenase

This is an abbreviated version!
For detailed information about tryptophan 5-monooxygenase, go to the full flat file.

Word Map on EC 1.14.16.4

Reaction

L-tryptophan
+
a 5,6,7,8-tetrahydropteridine
+
O2
=
5-hydroxy-L-tryptophan
+
a 4a-hydroxy-5,6,7,8-tetrahydropteridine

Synonyms

hTPH2, indoleacetic acid-5-hydroxylase, L-tryptophan 5-hydroxylase, L-tryptophan hydroxylase, oxygenase, tryptophan 5-mono-, peripheral tryptophan hydroxylase, PTMO, putative tryptophan monooxygenase, TH2, TPH, TPH-1, TPH-2, TPH1, TPH2, TRpOH, tryptophan 5-hydroxylase, tryptophan 5-monooxygenase, tryptophan hydroxylase, tryptophan hydroxylase 1, tryptophan hydroxylase 2, tryptophan hydroxylase I, tryptophan hydroxylase isoform 1, tryptophan hydroxylase isoform 2, tryptophan hydroxylase isoform2, tryptophan hydroxylase type I, tryptophan hydroxylase-1, tryptophan hydroxylase-2, tryptophan-5-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.16.4 tryptophan 5-monooxygenase

Source Tissue

Source Tissue on EC 1.14.16.4 - tryptophan 5-monooxygenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
of fetus
Manually annotated by BRENDA team
-
dermal
Manually annotated by BRENDA team
-
pituitary cell line
Manually annotated by BRENDA team
low levels of TPH-2
Manually annotated by BRENDA team
expression of the native truncated mutant TPH2
Manually annotated by BRENDA team
low levels of TPH-2
Manually annotated by BRENDA team
TPH expression pattern during development, TPH expression was found from tailbud stage in the precursor cells of the visceral ganglion and in the tail
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
in vivo predominantly localized to normal and malignant melanocytes
Manually annotated by BRENDA team
main expression of gene TPH at commissure axonal connections in the ventral nerve cords
Manually annotated by BRENDA team
expression of TPH2
Manually annotated by BRENDA team
expression of the native truncated mutant TPH2
Manually annotated by BRENDA team
-
raphe cell line
Manually annotated by BRENDA team
-
human small cell lung carcinoma cell line, SHP-77 cells preferentially express TPH1 over TPH2 mRNA
Manually annotated by BRENDA team
-
ventral horn, enzyme expression in muscle after exercise-induced fatigue and control muscle, overview
Manually annotated by BRENDA team
-
TPH1
Manually annotated by BRENDA team
-
TPH1
Manually annotated by BRENDA team
additional information