1.14.16.4: tryptophan 5-monooxygenase
This is an abbreviated version!
For detailed information about tryptophan 5-monooxygenase, go to the full flat file.
Word Map on EC 1.14.16.4
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1.14.16.4
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serotonin
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serotonergic
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raphe
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5-hydroxytryptamine
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monoamine
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dorsal
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dopamine
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neurotransmitter
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hippocampus
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antidepressant
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reuptake
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5-hydroxytryptophan
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anxiety
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psychiatric
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midbrain
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striatum
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hypothalamus
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neurochemical
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5-hydroxyindoleacetic
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mood
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enterochromaffin
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neurotransmission
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5-hiaa
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p-chlorophenylalanine
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fluoxetine
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pineal
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brainstem
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alpha-methyl-p-tyrosine
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monoaminergic
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5,7-dihydroxytryptamine
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analysis
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methamphetamine
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autoreceptors
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slc6a4
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immobility
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pargyline
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n-acetylserotonin
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neostriatal
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5-httlpr
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medicine
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citalopram
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antidepressant-like
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carcinoid
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biopterins
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impulsivity
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oxidase-a
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tetrahydropterins
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fenfluramine
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impulsive
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8-oh-dpat
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5-hydroxyindole
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drug development
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3,4-methylenedioxymethamphetamine
- 1.14.16.4
- serotonin
-
serotonergic
-
raphe
- 5-hydroxytryptamine
-
monoamine
-
dorsal
- dopamine
-
neurotransmitter
- hippocampus
-
antidepressant
-
reuptake
- 5-hydroxytryptophan
-
anxiety
-
psychiatric
- midbrain
- striatum
- hypothalamus
-
neurochemical
-
5-hydroxyindoleacetic
-
mood
-
enterochromaffin
-
neurotransmission
-
5-hiaa
- p-chlorophenylalanine
- fluoxetine
-
pineal
- brainstem
- alpha-methyl-p-tyrosine
-
monoaminergic
-
5,7-dihydroxytryptamine
- analysis
- methamphetamine
-
autoreceptors
-
slc6a4
-
immobility
- pargyline
- n-acetylserotonin
- neostriatal
-
5-httlpr
- medicine
- citalopram
-
antidepressant-like
- carcinoid
- biopterins
-
impulsivity
-
oxidase-a
- tetrahydropterins
- fenfluramine
-
impulsive
-
8-oh-dpat
- 5-hydroxyindole
- drug development
- 3,4-methylenedioxymethamphetamine
Reaction
Synonyms
hTPH2, indoleacetic acid-5-hydroxylase, L-tryptophan 5-hydroxylase, L-tryptophan hydroxylase, oxygenase, tryptophan 5-mono-, peripheral tryptophan hydroxylase, PTMO, putative tryptophan monooxygenase, TH2, TPH, TPH-1, TPH-2, TPH1, TPH2, TRpOH, tryptophan 5-hydroxylase, tryptophan 5-monooxygenase, tryptophan hydroxylase, tryptophan hydroxylase 1, tryptophan hydroxylase 2, tryptophan hydroxylase I, tryptophan hydroxylase isoform 1, tryptophan hydroxylase isoform 2, tryptophan hydroxylase isoform2, tryptophan hydroxylase type I, tryptophan hydroxylase-1, tryptophan hydroxylase-2, tryptophan-5-hydroxylase
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Posttranslational Modification
Posttranslational Modification on EC 1.14.16.4 - tryptophan 5-monooxygenase
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phosphoprotein
phosphoprotein
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phosphorylation of TPH2 at Ser19 by calmodulin-dependent protein kinase II activates the enzyme
phosphoprotein
TPH2 is phosphorylated by protein kinase A at Ser19 and Ser104, and by Ca2+/calmodulin dependent protein kinase II at Ser19, phosphorylation at Ser19 activates TPH2 by about 30%, Ser19 is phosphorylated to a stoichiometry of up to 50% in HEK-293 cells expressing TPH2, overview, in vivo phosphorylation in transiently transfected HEK-293 cells occurs with Ser19 phosphorylation stoichiometry of maximally 0.5 mol of phosphate/mol of enzyme subunit in resting cells, which is increasable by cell activation with okadaic acid, overview
phosphoprotein
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tryptophan hydroxylase becomes phosphorylated at Ser58 in brain stem of 1-month-old SAMP6