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1.14.16.1: phenylalanine 4-monooxygenase

This is an abbreviated version!
For detailed information about phenylalanine 4-monooxygenase, go to the full flat file.

Word Map on EC 1.14.16.1

Reaction

L-phenylalanine
+
a 5,6,7,8-tetrahydropteridine
 +
O2
=
L-tyrosine
 +
a 4a-hydroxy-5,6,7,8-tetrahydropteridine

Synonyms

cePAH, DicPAH, EC 1.14.3.1, EC 1.99.1.2, HPAH, L-phenylalanine 4-hydroxylase, oxygenase, phenylalanine 4-mono-, P4H, PAH, PheH, phenylalaninase, phenylalanine 4-hydroxylase, phenylalanine hydroxylase, phenylalanine monooxygenase, PheOH, phhA

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.16.1 phenylalanine 4-monooxygenase

KI Value

KI Value on EC 1.14.16.1 - phenylalanine 4-monooxygenase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0015
(7R)-5,6,7,8-tetrahydrobiopterin
-
-
0.00027 - 0.0032
3,4-Dihydroxystyrene
1.1
4-Chlorophenylalanine
-
-
0.0023 - 0.0049
7(S)-tetrahydrobiopterin
pH 7.0, 25°C, recombinant enzyme, versus (6R)-tetrahydrobiopterin
1.7
Acetohydroxamate
-
-
0.0000015 - 0.0000018
bathophenanthroline
0.07
benzohydroxamate
-
-
0.01
catechol
-
-
0.026
deaza-6-methyltetrahydropterin
-
-
3.5 - 8.11
L-methionine
0.3
L-tryptophan
-
competitive vs. iron
0.11
phenylalanine
-
competitive vs. iron
5.01 - 13.14
S-carboxy-methyl-L-cysteine
17.23
S-carboxymethyl-L-cysteine
-
in pooled hepatic cytosolic enzyme fraction, at 37°C
0.41 - 0.5
S-methyl-ergothionine
17.32 - 41.53
S-methyl-L-cysteine
0.3
tyrosine
-
competitive vs. iron
additional information
additional information
inhibition kinetics
-