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1.14.15.5: corticosterone 18-monooxygenase

This is an abbreviated version!
For detailed information about corticosterone 18-monooxygenase, go to the full flat file.

Word Map on EC 1.14.15.5

Reaction

corticosterone
+ 2 reduced adrenodoxin +
O2
 + 2 H+ =
18-hydroxycorticosterone
 + 2 oxidized adrenodoxin +
H2O

Synonyms

corticosterone 18-hydroxylase, corticosterone methyl oxidase, CYP11B2, cytochrome P450 11B2, oxygenase, corticosterone 18-mono-

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.15.5 corticosterone 18-monooxygenase

Substrates Products

Substrates Products on EC 1.14.15.5 - corticosterone 18-monooxygenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
corticosterone + reduced adrenal ferredoxin + O2
18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O
show the reaction diagram
additional information
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reduced enzyme activity occurs in hyponatremia and hyperkalemia due to an isolated aldosterone biosynthesis defect, the phenotype can be rescued by a fludrocortisone replacement therapy, overview
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