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1.14.15.5: corticosterone 18-monooxygenase

This is an abbreviated version!
For detailed information about corticosterone 18-monooxygenase, go to the full flat file.

Word Map on EC 1.14.15.5

Reaction

corticosterone
+ 2 reduced adrenodoxin +
O2
+ 2 H+ =
18-hydroxycorticosterone
+ 2 oxidized adrenodoxin +
H2O

Synonyms

corticosterone 18-hydroxylase, corticosterone methyl oxidase, CYP11B2, cytochrome P450 11B2, oxygenase, corticosterone 18-mono-

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.15.5 corticosterone 18-monooxygenase

Disease

Disease on EC 1.14.15.5 - corticosterone 18-monooxygenase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adrenogenital Syndrome
CYP17- and CYP11B-dependent steroid hydroxylases as drug development targets.
cholinesterase deficiency
Genetic screening in the Persian Jewish community: A pilot study.
corticosterone 18-monooxygenase deficiency
Biochemical diagnosis and management of corticosterone methyl oxidase type II deficiency.
Computational analysis of functional single nucleotide polymorphisms associated with the CYP11B2 gene.
Congenital hypoaldosteronism: the Visser-Cost syndrome revisited.
Corticosterone Methyl Oxidase Deficiency Type 1 with Normokalemia in an Infant.
Hereditary defect in biosynthesis of aldosterone: aldosterone synthase deficiency 1964-1997.
Homozygosity for a mutation in the CYP11B2 gene in an infant with congenital corticosterone methyl oxidase deficiency type II.
Multisteroid analysis in children with terminal aldosterone biosynthesis defects.
Mutation THR-185 ILE is associated with corticosterone methyl oxidase deficiency type II.
The effect of ACTH stimulation on plasma steroids in two patients with congenital hypoaldosteronism and in their relatives.
Dehydration
Corticosterone methyl oxidase type II deficiency: a cause of failure to thrive and recurrent dehydration in early infancy.
Diabetes Mellitus
Acquired partial corticosterone methyl oxidase type II defect in diabetes mellitus. Case of hyperreninemic hypoaldosteronism.
Disorders of Sex Development
CYP17- and CYP11B-dependent steroid hydroxylases as drug development targets.
Herpes Zoster
18-Hydroxy-11-deoxycortisol: a new steroid isolated from incubations of the adrenal with 11-deoxycortisol.
Reversible hyporeninemic hypoaldosteronism in a patient with tetraplegia.
Hyperaldosteronism
Computational analysis of functional single nucleotide polymorphisms associated with the CYP11B2 gene.
Hypoaldosteronism
Acquired partial corticosterone methyl oxidase type II defect in diabetes mellitus. Case of hyperreninemic hypoaldosteronism.
Severe hypoaldosteronism due to corticosterone methyl oxidase type II deficiency in two boys: metabolic and gas chromatography-mass spectrometry studies.
[Primary hypoaldosteronism and secondary pseudo-hypoaldosteronism]
Muscular Diseases
Genetic screening in the Persian Jewish community: A pilot study.
steroid 11beta-monooxygenase deficiency
Corticosterone Methyl Oxidase Deficiency Type 1 with Normokalemia in an Infant.