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1.14.15.4: steroid 11beta-monooxygenase

This is an abbreviated version!
For detailed information about steroid 11beta-monooxygenase, go to the full flat file.

Word Map on EC 1.14.15.4

Reaction

A steroid
+ 2 reduced adrenodoxin +
O2
 + 2 H+ =
an 11beta-hydroxysteroid
 + 2 oxidized adrenodoxin +
H2O

Synonyms

11-hydroxylase, 11 beta-hydroxylase, 11-beta hydroxylase, 11-beta-hydroxylase, 11-hydroxylase, 11beta hydroxylase, 11beta-hydroxylase, ALDOS, Aldosterone synthase, Aldosterone-synthesizing enzyme, C450XIB2, CYP11B1, CYP11B2, cyp11beta, CYPXIB, CYPXIB1, CYPXIB2, CYPXIB3, cytochrome 11beta-hydroxylase, cytochrome P-45011-beta, cytochrome P450 11B1, cytochrome P450 11B2, cytochrome P450 11beta-hydroxylase, cytochrome P45011beta, cytochrome P45011beta-hydroxylase, EC 1.14.1.6, EC 1.99.1.7, P-450(11 beta,aldo), P-450Aldo, P-450c11, P-450C18, P-450XIB1, P450 11beta-hydroxylase, P450(11 beta)-DS, P45011beta, P450C11, Steroid 11-beta-hydroxylase, steroid 11-hydroxylase, steroid 11beta-hydroxylase, steroid 11beta-monooxygenase, steroid 11beta/18-hydroxylase, Steroid 18-hydroxylase, steroid-11beta-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.15.4 steroid 11beta-monooxygenase

Specific Activity

Specific Activity on EC 1.14.15.4 - steroid 11beta-monooxygenase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.00000314
-
aldosterone production, mitochondria from zona glomerulosa
0.0000236
-
18-hydroxycorticosterone production, mitochondria from zona fasciculata
0.00003
-
18-hydroxylation
0.000119
-
18-hydroxycorticosterone production, mitochondria from zona glomerulosa
0.000171
-
18-hydroxylation activity, 4% O2, 96% N2
0.000211
-
18-hydroxylation activity, 21% O2, 79% N2
0.001061
-
deoxycorticosterone, 18-hydroxylation activity in
0.00205
-
11beta-hydroxylation activity, 4% O2, 96% N2
0.00206
-
18-hydroxydeoxycorticosterone production, mitochondria from zona glomerulosa
0.00278
-
11beta-hydroxylation activity, 21% O2, 79% N2
0.0053
-
11beta-hydroxylation
0.00599
-
18-hydroxydeoxycorticosterone production, mitochondria from zona fasciculata
0.00691
-
corticosterone production, mitochondria from zona glomerulosa
0.00951
-
corticosterone production, mitochondria from zona fasciculata
0.00968
-
+/-0.00126, 40.8% inhibition by 0.4 mM metyrapol, adrenal tissue
0.00986
-
+/-0.00044, 39.7% inhibition by 0.4 mM metyrapone, adrenal tissue
0.01011
-
+/-0.00126, 38.1% inhibition by 0.4 mM (+)-metyrapol, adrenal tissue
0.01081
-
+/-0.00269, 33.8% inhibition by 0.4 mM (-)-metyrapol, adrenal tissue
0.01193
-
deoxycorticosterone, 11beta-hydroxylation activity
0.01633
-
+/-0.00237, no inhibitor, adrenal tissue
0.0198
-
purified recombinant enzyme
1.35 - 1.36
-
corticosterone, enzyme incorporated into liposomes
1.38
-
corticosterone, soluble form of enzyme
additional information