1.14.15.3: alkane 1-monooxygenase

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For detailed information about alkane 1-monooxygenase, go to the full flat file.

Reaction

Synonyms

1-hydroxylase, alkane 1-hydrolase, alkane hydroxylase, alkane mono-oxygenase, alkane monooxygenase, alkane omega-hydroxylase, alkane-1-monooxygenase 1, alkane-1-monooxygenase 2, AlkB, AlkB1, AlkB2, AlkW1, AlkW2, AlmA, AlmA-like alkane hydroxylase, BMO, butane monooxygenase, CYP omega hydroxylase, CYP omega-hydroxylase, Cyp153, CYP153 homologue, CYP153A, CYP153D17, CYP4 P450, CYP450 4A omega-hydroxylase, CYP450 omega-hydroxylase, CYP4A, CYP4A10, CYP4A11, CYP4A14, CYP4AII, CYP4d21, CYP86A1, CYP86B1, CYP94A1, CYPA11 P450, CYPIVA1, CYPIVA11, CYPIVA2, CYPIVA3, CYPIVA5, CYPIVA6, CYPIVA7, cytochrome P-450 omega-hydroxylase, cytochrome P450 alkane hydroxylase, cytochrome P450 omega hydroxylase, cytochrome P450-dependent fatty acid omega-hydroxylase, diiron omega-hydroxylase, FA omega-hydroxylase, fatty acid omega-hydrolase, Fatty acid omega-hydroxylase, Gpo1, hexane hydroxylase, Lauric acid omega-hydroxylase, MAH1-1, MAH1-2, male-specific fatty acid omega-hydroxylase, medium-chain alkane hydroxylase, methane monooxygenase, More, omega hydroxylase, omega-hydrolase, omega-hydroxylase, P-450 HK omega, P450-HL-omega, P452, Prm1ABCD, Prm2ABCD, propane monooxygenase, Rieske-type alkane monooxygenase, sex-specific enzyme 1, SXE1, UAM-Ps1, very long chain fatty acid hydroxylase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.15.3 alkane 1-monooxygenase

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Results	in table
9	Activating Compound
1263	AA Sequence
14	Application
1	CAS Registry Number
36	Cloned(Commentary)
69	Cofactor
4	Crystallization (Commentary)
611	Disease/ Diagnostics
19	Expression
39	General Information
4	General Stability
57	Inhibitors
2	Ki Value [mM]
16	KM Value [mM]
46	Localization
26	Metals/Ions
19	Molecular Weight [Da]
58	Natural Substrates/ Products (Substrates)
419	Organism
5	Pathway
1	PDB ID
13	pH Optimum
1	pH Range
1	Posttranslational Modification
40	Protein Variants
13	Purification (Commentary)
1	Reaction
4	Reaction Type
164	Reference
3	Renatured (Commentary)
44	Source Tissue
15	Specific Activity [micromol/min/mg]
7	Storage Stability
288	Substrates and Products (Substrate)
17	Subunits
195	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
5	Temperature Stability [°C]
33	Turnover Number [1/s]

Application

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Application on EC 1.14.15.3 - alkane 1-monooxygenase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

analysis

Rhodococcus sp.

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a certain type of alkB gene is present in almost everymember of the genus Rhodococcus. The alkB gene type may be applicable for differentiating closely related Rhodococcus species, properly assigning environmental isolates to existing Rhodococcus species, and assessing whether a new Rhodococcus isolate represents a novel species of the genus

746523

degradation

3 entries

drug development

2 entries

environmental protection

2 entries

synthesis

4 entries

additional information

2 entries

degradation

uncultured bacterium

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formation of specific bacterial communities with reduced diversity after three week incubation of seawater with heptane, hexadecane, diesel fuel or crude oil. The isolates belong to well-known oil-degrading strains from the phyla Proteobacteria and Actinobacteria, whereas the genera Pseudomonas and Rhodococcus are represented with the biggest number of strains

745673

degradation

Pseudomonas aeruginosa

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strain SJTD-1 efficiently mineralizes medium- and long-chain n-alkanes (C12-C30) as its sole carbon source within seven days, showing optimal growth on n-hexadecane, followed by n-octadecane, and n-eicosane. In 36 h, 500 mg/l of tetradecane, hexadecane, and octadecane are transformed completely; and 2 g/l n-hexadecane is degraded to undetectable levels within 72 h

746249

degradation

Pseudomonas aeruginosa SJTD-1

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strain SJTD-1 efficiently mineralizes medium- and long-chain n-alkanes (C12-C30) as its sole carbon source within seven days, showing optimal growth on n-hexadecane, followed by n-octadecane, and n-eicosane. In 36 h, 500 mg/l of tetradecane, hexadecane, and octadecane are transformed completely; and 2 g/l n-hexadecane is degraded to undetectable levels within 72 h

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drug development

Mus musculus

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CYP4A may be a therapeutic target in the control of inflammatory, vascular, and liver diseases, as well as peroxisome disorders of fatty acid metabolism

702154

drug development

Homo sapiens

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CYP4A may be a therapeutic target in the control of inflammatory, vascular, and liver diseases, as well as peroxisome disorders of fatty acid metabolism

702154

environmental protection

Pseudomonas putida

Q9WWW6

the enzyme has a tremendous biotechnological potential as a biocatalyst and promising application in the bioremediation of oil-contaminated environments

723970

environmental protection

Pseudomonas putida GPo1 / ATCC29347

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the enzyme has a tremendous biotechnological potential as a biocatalyst and promising application in the bioremediation of oil-contaminated environments

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synthesis

Pseudomonas putida

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bacterial alkane hydroxylases have tremendous potential as biocatalysts for the stereo- and regioselective transformation of a wide range of chemically inert unreactive alkanes into valuable reactive chemical precursors

724025

synthesis

Pseudomonas putida

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electrocatalytic conversion from alkanes to alcohols mediated by AlkB using a rubredoxin AlkG immobilized screen-printed carbon electrode. As electrons can be transferred from the reduced AlkG to AlkB in a two-phase manner, electrocatalytic conversion from alkanes to alcohols can be applied. Use for conversion of gaseous propane and n-butane to 1-propanol and 1-butanol, respectively

746483

synthesis

Pseudomonas putida GPo1 / ATCC29347

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bacterial alkane hydroxylases have tremendous potential as biocatalysts for the stereo- and regioselective transformation of a wide range of chemically inert unreactive alkanes into valuable reactive chemical precursors

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synthesis

Pseudomonas putida GPo1

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electrocatalytic conversion from alkanes to alcohols mediated by AlkB using a rubredoxin AlkG immobilized screen-printed carbon electrode. As electrons can be transferred from the reduced AlkG to AlkB in a two-phase manner, electrocatalytic conversion from alkanes to alcohols can be applied. Use for conversion of gaseous propane and n-butane to 1-propanol and 1-butanol, respectively

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additional information

Pseudomonas putida

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the enzyme is useful in a whole-cell biotransformation system by recombinant expression in Escherichia coli to regioselectively synthesize 2,2-, 3,3- and 4,4-difluorooctan-1-ols, from simple and inexpensive starting materials, method evaluation, overview

713529

additional information

Pseudomonas putida GPo1 / ATCC29347

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the enzyme is useful in a whole-cell biotransformation system by recombinant expression in Escherichia coli to regioselectively synthesize 2,2-, 3,3- and 4,4-difluorooctan-1-ols, from simple and inexpensive starting materials, method evaluation, overview

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