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1.14.15.22: vitamin D 1,25-hydroxylase

This is an abbreviated version!
For detailed information about vitamin D 1,25-hydroxylase, go to the full flat file.

Word Map on EC 1.14.15.22

Reaction

calcidiol
+ 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ +
O2
=
calcitriol
+ 2 oxidized ferredoxin [iron-sulfur] cluster +
H2O

Synonyms

CYP105A1, cytochrome P450SU-1, Streptomyces griseolus cytochrome P450SU-1, vitamin D3 dihydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.15.22 vitamin D 1,25-hydroxylase

Reference

Reference on EC 1.14.15.22 - vitamin D 1,25-hydroxylase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sawada, N.; Sakaki, T.; Yoneda, S.; Kusudo, T.; Shinkyo, R.; Ohta, M.; Inouye, K.
Conversion of vitamin D3 to 1alpha,25-dihydroxyvitamin D3 by Streptomyces griseolus cytochrome P450SU-1
Biochem. Biophys. Res. Commun.
320
156-164
2004
Streptomyces griseolus (P18326), Streptomyces griseolus
Manually annotated by BRENDA team
Hayashi, K.; Yasuda, K.; Yogo, Y.; Takita, T.; Yasukawa, K.; Ohta, M.; Kamakura, M.; Ikushiro, S.; Sakaki, T.
Sequential hydroxylation of vitamin D2 by a genetically engineered CYP105A1
Biochem. Biophys. Res. Commun.
473
853-858
2016
Streptomyces griseolus (P18326)
Manually annotated by BRENDA team
Hayashi, K.; Sugimoto, H.; Shinkyo, R.; Yamada, M.; Ikeda, S.; Ikushiro, S.; Kamakura, M.; Shiro, Y.; Sakaki, T.
Structure-based design of a highly active vitamin D hydroxylase from Streptomyces griseolus CYP105A1
Biochemistry
47
11964-11972
2008
Streptomyces griseolus (P18326), Streptomyces griseolus
Manually annotated by BRENDA team
Sugimoto, H.; Shinkyo, R.; Hayashi, K.; Yoneda, S.; Yamada, M.; Kamakura, M.; Ikushiro, S.; Shiro, Y.; Sakaki, T.
Crystal structure of CYP105A1 (P450SU-1) in complex with 1alpha,25-dihydroxyvitamin D3
Biochemistry
47
4017-4027
2008
Streptomyces griseolus (P18326), Streptomyces griseolus
Manually annotated by BRENDA team
Hayashi, K.; Yasuda, K.; Sugimoto, H.; Ikushiro, S.; Kamakura, M.; Kittaka, A.; Horst, R.L.; Chen, T.C.; Ohta, M.; Shiro, Y.; Sakaki, T.
Three-step hydroxylation of vitamin D3 by a genetically engineered CYP105A1: enzymes and catalysis
FEBS J.
277
3999-4009
2010
Streptomyces griseolus (P18326)
Manually annotated by BRENDA team