1.14.15.18: calcidiol 1-monooxygenase

This is an abbreviated version!
For detailed information about calcidiol 1-monooxygenase, go to the full flat file.

Reaction

Synonyms

1-hydroxylase-25-hydroxyvitamin D3, 1-OHase, 1alpha,25-dihydroxyvitamin D hydroxylase, 1alpha-hydroxylase, 1alpha-OHase, 1alphaOHase, 25 hydroxy-vitamin D3-1alpha hydroxylase, 25(OH)VD3 1alpha-hydroxylase, 25-hydroxy D3-1alpha-hydroxylase, 25-hydroxycholecalciferol 1-hydroxylase, 25-hydroxycholecalciferol 1-monooxygenase, 25-hydroxycholecalciferol 1alpha-hydroxylase, 25-hydroxycholecalciferol-1-hydroxylase, 25-hydroxyvitamin D 1alpha-hydroxylase, 25-hydroxyvitamin D-1 alpha-hydroxylase, 25-hydroxyvitamin D-1-alpha-hydroxylase, 25-hydroxyvitamin D-1alpha-hydroxylase, 25-hydroxyvitamin D3 1alpha-hydroxylase, 25-hydroxyvitamin D3-1alpha-hydroxylase, 25-hydroxyvitamin-D3-1alpha-hydroxylase, CYB27B1, CYP1alpha, CYP27A, CYP27B1, cytochrome P450 25-hydroxyvitamin D3-1alpha-hydroxylase, EC 1.14.13.13, extra-renal 25-hydroxyvitamin D-1alpha-hydroxylase, extra-renal 25-hydroxyvitamin D3 1alpha-hydroxylase, hydroxylase, 25-hydroxcholecalciferol 1-, More, oxygenase, 25-hydroxycholecalciferol 1-mono-, P450 cytochrome 25-hydroxyvitamin D3 1alpha-hydroxylase, VD3 25-hydroxylase, VDH, vitamin D 1alpha-hydroxylase, vitamin D hydroxylase, vitamin D3 25- and 1alpha-hydroxylase, vitamin D3 25-hydroxylase, vitamin D3 hydroxylase, [25(OH)D3]-1alpha-hydroxylase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.15.18 calcidiol 1-monooxygenase

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Results	in table
27	Activating Compound
13	AA Sequence
3	Application
1	CAS Registry Number
15	Cloned(Commentary)
45	Cofactor
2	Crystallization (Commentary)
1665	Disease/ Diagnostics
9	Expression
3	General Information
1	General Stability
74	Inhibitors
6	kcat/KM [mM/s]
4	Ki Value [mM]
29	KM Value [mM]
32	Localization
5	Metals/Ions
17	Molecular Weight [Da]
54	Natural Substrates/ Products (Substrates)
85	Organism
5	Pathway
6	pH Optimum
1	pH Range
1	Posttranslational Modification
18	Protein Variants
12	Purification (Commentary)
31	Reaction
3	Reaction Type
85	Reference
140	Source Tissue
31	Specific Activity [micromol/min/mg]
4	Storage Stability
137	Substrates and Products (Substrate)
5	Subunits
90	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
14	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.14.15.18 - calcidiol 1-monooxygenase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

1,25-Dihydroxycholecalciferol

5 entries

22-oxacalcitriol

Rattus norvegicus

-

vitamin D3 analogue, inhibits in vitro and in vivo

440122

25-hydroxy-3-deoxy-2-oxavitamin D3

Gallus gallus

-

vitamin D3 analogue, competitive inhibition

440123

25-hydroxydihydrotachysterol3

Gallus gallus

-

-

440101

25-hydroxyvitamin D2

Mus musculus

-

CYP27B1 shows inhibition when substrate concentrations in the membrane are greater than 4 times Km, more pronounced with 25-hydroxyvitamin D3 than with 25-hydroxyvitamin D2

712883

25-hydroxyvitamin D3

Mus musculus

-

CYP27B1 shows inhibition when substrate concentrations in the membrane are greater than 4 times Km, more pronounced with 25-hydroxyvitamin D3 than with 25-hydroxyvitamin D2

712883

3-deoxy-2-oxa-9(11)-didehydro-25-hydroxyvitamin D3

Gallus gallus

-

vitamin D3 analogue, competitive inhibition

440123

A-homo-3-deoxy-2-oxa-25-hydroxyvitamin D3

Gallus gallus

-

vitamin D3 analogue, competitive inhibition

440123

Aminoglutethimide

Gallus gallus

-

enzyme of intact mitochondria

440109

antimycin A

5 entries

Ca2+

Gallus gallus

-

-

440104, 440110

clotrimazole

Homo sapiens

-

in vivo in MCF-7 cells

671357

CN-

Mammalia

-

-

440118

CO

5 entries

cyanide

3 entries

dinitrophenol

4 entries

diphenyl-p-phenylenediamine

3 entries

Epidermal growth factor

Homo sapiens

-

decreases mRNA expression in less differentiated cells like Caco-2/AQ and COGA-1A and -1E; i.e. EGF

440130

ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid

Gallus gallus

-

-

440104

Glutethimide

Mammalia

-

-

440118

itraconzole

Danio rerio

A0A097HUX0

-

737985

ketoconazole

Mus musculus

-

-

440127

metapyrone

Gallus gallus

-

-

440109

Metyrapone

5 entries

Mn2+

Gallus gallus

-

-

440110

Natural inhibitors

4 entries

-

oligomycin

Gallus gallus

-

-

440101

p-chloromercuribenzoate

Gallus gallus

-

-

440101

p-Trifluoromethoxyphenylhydrazone

Cavia porcellus

-

-

440116

phosphate

2 entries

rotenone

2 entries

Sr2+

Gallus gallus

-

-

440110

sucrose

Gallus gallus

-

hypertonic

440101

Tris-chloride buffer

Gallus gallus

-

-

440101

vitamin D3

2 entries

additional information

6 entries

-

1,25-Dihydroxycholecalciferol

Cavia porcellus

-

calcitriol

440116

1,25-Dihydroxycholecalciferol

Gallus gallus

-

calcitriol

440101

1,25-Dihydroxycholecalciferol

Homo sapiens

-

calcitriol

440120

1,25-Dihydroxycholecalciferol

Homo sapiens

-

calcitriol; decreases mRNA expression in less differentiated cells like Caco-2/AQ and COGA-1A and -1E

440130

1,25-Dihydroxycholecalciferol

Mus musculus

O35084

calcitriol; in vivo only inhibitory in vitamin D receptor containing cells, therefore: negative feedback inhibition is mediated by the enzyme through liganded vitamin D receptor

440125

antimycin A

Cavia porcellus

-

no inhibition of hydroxylation

440116

antimycin A

Gallus gallus

-

-

440101

antimycin A

Gallus gallus

-

higher inhibition rate with succinate as electron donor than with malate

440110

antimycin A

Mammalia

-

-

440118

antimycin A

Rattus norvegicus

-

inhibition occurs with succinate reaction support, no inhibition together with malate

440106

CO

Cavia porcellus

-

-

440116

CO

Gallus gallus

-

50% O2/50% CO2 incubation atmosphere

440101

CO

Mammalia

-

-

440118

CO

Mus musculus

-

-

440127

CO

Rattus norvegicus

-

no inhibition

440117

cyanide

Cavia porcellus

-

-

440116

cyanide

Gallus gallus

-

-

440101

cyanide

Mammalia

-

-

440118

dinitrophenol

Gallus gallus

-

-

440101

dinitrophenol

Gallus gallus

-

higher inhibition rate with malate as electron donor than with succinate

440110

dinitrophenol

Mammalia

-

-

440118

dinitrophenol

Rattus norvegicus

-

-

440106

diphenyl-p-phenylenediamine

Gallus gallus

-

-

440101

diphenyl-p-phenylenediamine

Rattus norvegicus

-

no inhibition

440106

diphenyl-p-phenylenediamine

Rattus norvegicus

-

-

440117

Metyrapone

Gallus gallus

-

-

440101

Metyrapone

Gallus gallus

-

enzyme of intact mitochondria

440109

Metyrapone

Mammalia

-

-

440118

Metyrapone

Mus musculus

-

-

440127

Metyrapone

Rattus norvegicus

-

-

440106, 440117

Natural inhibitors

Gallus gallus

-

from rat and pig tissues

440102

-

Natural inhibitors

Gallus gallus

-

rat plasma 25-hydroxyvitamin D3 binding protein

440103

-

Natural inhibitors

Gallus gallus

-

from rat serum

440105

-

Natural inhibitors

Mammalia

-

vitamin D binding protein

440118

-

phosphate

Gallus gallus

-

-

440101, 440104, 440110

phosphate

Homo sapiens

-

no inhibition

440120

rotenone

Cavia porcellus

-

no inhibition of hydroxylation

440116

rotenone

Mammalia

-

-

440118

vitamin D3

Homo sapiens

-

-

440131

vitamin D3

Mus musculus

-

-

440127, 440131

additional information

Gallus gallus

-

inhibition by renal mitochondrial protein kinase-catalyzed phosphorylation

440108

-

additional information

Gallus gallus

-

no inhibition with Ba2+, acetate, sulfate

440110

-

additional information

Gallus gallus

-

overview, inhibitory potency of several vitamin D3 analogues

440123

-

additional information

Homo sapiens

O15528

inhibitory effects of the MEK inhibitor PD98059, p38 MAPK inhibitor SB203580, and JNK inhibitor SP600125 on the IFNgamma/PMA-induced or IFNgamma/LPS-induced 1alpha-hydroxylase mRNA expression in THP1 cells, overview

675057

-

additional information

Homo sapiens

-

inhibitory effects of the MEK inhibitor PD98059, p38 MAPK inhibitor SB203580, and JNK inhibitor SP600125 on the IFNgamma/PMA-induced or IFNgamma/LPS-induced 1alpha-hydroxylase mRNA expression in THP1 cells, overview

675057

-

additional information

Oryctolagus cuniculus

-

the enzyme is not affected by cardiolipin and dilauroylphosphatidylcholine

671685

-