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1.14.15.17: pheophorbide a oxygenase

This is an abbreviated version!
For detailed information about pheophorbide a oxygenase, go to the full flat file.

Word Map on EC 1.14.15.17

Reaction

epoxypheophorbide a
+
H2O
=
red chlorophyll catabolite

Synonyms

accelerated cell death 1, ACD1, AtPaO, chloroplast pheophorbide a oxygenase PaO1, chloroplast pheophorbide a oxygenase PaO2, CitPaO, EC 1.14.12.20, lethal leaf spot protein LLS1, lethal leaf-spot 1 homolog, Lls1, PAO, pheide a monooxygenase, pheide a oxygenase, pheophorbide a oxygenase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.15.17 pheophorbide a oxygenase

Systematic Name

Systematic Name on EC 1.14.15.17 - pheophorbide a oxygenase

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SYSTEMATIC NAME
IUBMB Comments
pheophorbide-a,ferredoxin:oxygen oxidoreductase (biladiene-forming)
This enzyme catalyses a key reaction in chlorophyll degradation, which occurs during leaf senescence and fruit ripening in higher plants. The enzyme from Arabidopsis contains a Rieske-type iron-sulfur cluster [2] and requires reduced ferredoxin, which is generated either by NADPH through the pentose-phosphate pathway or by the action of photosystem I [4]. While still attached to this enzyme, the product is rapidly converted into primary fluorescent chlorophyll catabolite by the action of EC 1.3.7.12, red chlorophyll catabolite reductase [2,6]. Pheophorbide b acts as an inhibitor. In 18O2 labelling experiments, only the aldehyde oxygen is labelled, suggesting that the other oxygen atom may originate from H2O [1].