1.14.15.15: cholestanetriol 26-monooxygenase

This is an abbreviated version!
For detailed information about cholestanetriol 26-monooxygenase, go to the full flat file.

Word Map on EC 1.14.15.15

1.14.15.15

bile

xanthomatosis

cerebrotendinous

27-hydroxycholesterol

chenodeoxycholic

cholestanol

tendon

xanthomas

oxysterols

cataract

cyp7a1

27-hydroxylation

cholic

12alpha-hydroxylase

cholecalciferol

lipid-storage

lxralpha

7alpha-hydroxylated

cholestyramine

7-ketocholesterol

7alpha-hydroxy-4-cholesten-3-one

alpha-hydroxyvitamin

medicine

lithogenic

Reaction

(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al

+ 2 reduced adrenodoxin + 2 H+ +

(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate

+ 2 oxidized adrenodoxin +

Synonyms

5beta-cholestane-3 alpha,7alpha,12alpha,26-tetrol dehydrogenase, 5beta-cholestane-3 alpha,7alpha,12alpha-triol-26-al oxidoreductase, 5beta-cholestane-3alpha,7alpha,12alpha-triol 26-hydroxylase, 5beta-cholestane-3alpha,7alpha,12alpha-triol 27-monooxygenase, 5beta-cholestane-3alpha,7alpha,12alpha-triol hydroxylase, cholestanetriol 26-hydroxylase, cholestanetriol 27-hydroxylase, cholesterol C-26 hydroxylase, cholesterol hydroxylase, CYP125A4, CYP27, CYP27A, CYP27A1, cytochrome P-450 sterol 26-hydroxylase, cytochrome P-450A, cytochrome P450 125A4, cytochrome P450 27A, cytochrome P450c27, dehydrogenase, cholestanetetrol 26-, EC 1.1.1.161, EC 1.14.13.15, EC 1.2.1.40, hydroxylase, 5beta-cholestane-3alpha,7alpha,12alpha-triol, More, oxygenase, cholestanetriol 26-mono-, P450 27A1, sterol 27-hydroxylase, TEHC-NAD oxidoreductase, vitamin D3 25-hydroxylase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.15.15 cholestanetriol 26-monooxygenase

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Results	in table
3	Activating Compound
146	AA Sequence
3	Application
2	CAS Registry Number
13	Cloned(Commentary)
31	Cofactor
384	Disease/ Diagnostics
4	Expression
22	General Information
23	Inhibitors
2	kcat/KM [mM/s]
3	Ki Value [mM]
9	KM Value [mM]
30	Localization
1	Metals/Ions
5	Molecular Weight [Da]
33	Natural Substrates/ Products (Substrates)
40	Organism
4	Pathway
5	PDB ID
9	pH Optimum
2	pH Range
2	Posttranslational Modification
20	Protein Variants
12	Purification (Commentary)
5	Reaction
3	Reaction Type
40	Reference
69	Source Tissue
6	Specific Activity [micromol/min/mg]
1	Storage Stability
73	Substrates and Products (Substrate)
4	Subunits
54	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Stability [°C]
10	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 1.14.15.15 - cholestanetriol 26-monooxygenase

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(24S)-3beta-hydroxy-24-methyl-5alpha-cholesta-8(14),22-dien-15-one + reduced adrenodoxin + H+ + O2

Homo sapiens

the substrate is a potential drug for lowering cholesterol in the treatment and/or prevention of coronary artery disease, but it is rapidly metabolized in the liver

702407

(25R)-5beta-cholestane-3alpha,7alpha,12alpha,27-tetraol + reduced adrenodoxin + O2

3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid + oxidized adrenodoxin + H2O

Oryctolagus cuniculus

674402

3beta-hydroxy-5alpha-cholest-8(14)-en-15-one + reduced adrenodoxin + H+ + O2

Homo sapiens

the substrate is a potential drug for lowering cholesterol in the treatment and/or prevention of coronary artery disease, but it is rapidly metabolized in the liver

702407

5-cholestene-3beta,7alpha-diol + reduced adrenodoxin + O2

5-cholestene-3alpha,7alpha,26-triol + oxidized adrenodoxin + H2O

Oryctolagus cuniculus

674399, 674400

5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + reduced adrenodoxin + O2

3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + oxidized adrenodoxin + H2O

3 entries

5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced adrenodoxin + H+ + O2

(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + oxidized adrenodoxin + H2O

Rattus norvegicus

705935

5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced adrenodoxin + O2

(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + oxidized adrenodoxin + H2O

2 entries

5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced adrenodoxin + O2

3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid + oxidzed adrenodoxin + H2O

Oryctolagus cuniculus

674402

5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced adrenodoxin + O2

5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + oxidized adrenodoxin + H2O

Oryctolagus cuniculus

674399, 674400

5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced adrenodoxin + O2

4 entries

5beta-cholestane-3alpha,7alpha-diol + reduced adrenodoxin + O2

5beta-cholestane-3alpha,7alpha,26-triol + oxidized adrenodoxin + H2O

Oryctolagus cuniculus

674399, 674400

7alpha-hydroxy-4-cholesten-3-one + reduced adrenodoxin + O2

7alpha,26-dihydroxy-4-cholesten-3-one + oxidized adrenodoxin + H2O

Oryctolagus cuniculus

674399, 674400

cholesterol + reduced adrenodoxin + H+ + O2

26-hydroxycholesterol + oxidized adrenodoxin + H2O

Oryctolagus cuniculus

674399, 674400

cholesterol + reduced adrenodoxin + O2

27-hydroxycholesterol + oxidized adrenodoxin + H2O

4 entries

additional information

4 entries