1.14.14.B9: fatty acid omega2/3-hydroxyase

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For detailed information about fatty acid omega2/3-hydroxyase, go to the full flat file.

Reaction

Synonyms

CYP4F11, CYP4F12, CYP4F8

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.14.B9 fatty acid omega2/3-hydroxyase

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Results	in table
4	AA Sequence
1	Application
1	Cloned(Commentary)
1	Cofactor
1	Localization
4	Organism
1	pH Optimum
2	Protein Variants
6	Reaction
3	Reference
2	Source Tissue
9	Substrates and Products (Substrate)
4	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Engineering

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Engineering on EC 1.14.14.B9 - fatty acid omega2/3-hydroxyase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

G328E

Homo sapiens

P98187, Q9HCS2

mutant oxidizes prostaglandin H2 analogs U-51605 and U-44069 as recombinant CYP4F8, but the hydroxylation of arachidonic acid is shifted from C-18 to C-19

729095

Y125F

Homo sapiens

P98187, Q9HCS2

missense mutation in substrate recognition site-1, occuring naturally in low frequency. The variant oxidizes prostaglandin H2 analogs U-51605, i.e. 9,11-diazo-prostadienoic acid, and U-44069, i.e. 9alpha,11alpha-epoxymethano-prostaglandin H2 in omega2 and omega3 position, but 4,7,10,13,16-(Z)-docosatetraenoic acid and 4,7,10,13,16-(Z)-docosapentaenoic acid are not oxidized

729095