1.14.14.39: isoleucine N-monooxygenase

This is an abbreviated version!
For detailed information about isoleucine N-monooxygenase, go to the full flat file.

Word Map on EC 1.14.14.39

1.14.14.39

cassava

glucoside

linamarin

manihot

esculenta

crantz

lotaustralin

sorghum

cyanide

lotus

japonicus

acyanogenic

cyp79s

hydroxynitrile

endodermis

bicolor

aerial

cyanohydrin

aldoximes

glucosinolate

acid-derived

oximes

petiole

l-valine

mesophyll

Reaction

+ 2 [reduced NADPH-hemoprotein reductase] + 2 O2 =

+ 2 [oxidized NADPH-hemoprotein reductase] +

+ 3 H2O

Synonyms

CYP79D1, CYP79D2, CYP79D3, CYP79D4, EC 1.14.13.117, valine N-monooxygenase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.14.39 isoleucine N-monooxygenase

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Results	in table
12	AA Sequence
2	Cloned(Commentary)
4	General Information
6	kcat/KM [mM/s]
7	KM Value [mM]
2	Localization
2	Molecular Weight [Da]
6	Organism
4	Pathway
1	Posttranslational Modification
4	Reaction
4	Reference
7	Source Tissue
8	Substrates and Products (Substrate)
1	Subunits
8	Synonyms
1	Systematic Name
7	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.14.14.39 - isoleucine N-monooxygenase

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L-isoleucine,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (N-hydroxylating)

This cytochrome P-450 (heme-thiolate) enzyme, found in plants, catalyses two successive N-hydroxylations of L-isoleucine, the committed step in the biosynthesis of the cyanogenic glucoside lotaustralin. The product of the two hydroxylations, N,N-dihydroxy-L-isoleucine, is labile and undergoes dehydration followed by decarboxylation, producing the oxime. It is still not known whether the decarboxylation is spontaneous or catalysed by the enzyme. The enzyme can also accept L-valine, but with a lower activity. cf. EC 1.14.14.38, valine N-monooxygenase.