1.14.14.29: 25/26-hydroxycholesterol 7alpha-hydroxylase

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For detailed information about 25/26-hydroxycholesterol 7alpha-hydroxylase, go to the full flat file.

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Synonyms

25-hydroxycholesterol 7alpha-hydroxylase, 25-hydroxycholesterol 7alpha-monooxygenase, 25-hydroxycholesterol-7alpha-hydroxylase, cholesterol 25-hydroxylase, Cyp39a1, CYP7B, CYP7B1, CYP7B1 oxysterol 7alpha-hydroxylase, CYPB1, cytochome P450 7B1, cytochrome P-450 oxysterol 7-alpha-hydroxylase, EC 1.14.13.100, EC 1.14.13.60, oxysterol 7 alpha-hydroxylase, oxysterol 7alpha-hydroxylase, oxysterol-7alpha-hydroxylase, Steroid hydroxylase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.14.29 25/26-hydroxycholesterol 7alpha-hydroxylase

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Results	in table
1	Activating Compound
4	AA Sequence
1	Application
2	CAS Registry Number
6	Cloned(Commentary)
19	Cofactor
391	Disease/ Diagnostics
3	Expression
8	General Information
13	Inhibitors
2	Ki Value [mM]
7	KM Value [mM]
8	Localization
2	Molecular Weight [Da]
12	Natural Substrates/ Products (Substrates)
31	Organism
2	Pathway
8	Protein Variants
4	Reaction
3	Reaction Type
30	Reference
38	Source Tissue
46	Substrates and Products (Substrate)
2	Subunits
45	Synonyms
1	Systematic Name
2	Turnover Number [1/s]

General Information

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General Information on EC 1.14.14.29 - 25/26-hydroxycholesterol 7alpha-hydroxylase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

metabolism

Homo sapiens

O75881

CYP7B1 is an enzyme expressed in many human tissues and implicated in cholesterol metabolism. In the liver, this protein is part of the alternate/acidic pathway for primary bile acid production while in brain, CYP7B1 provides the primary metabolic route for cholesterol derivatives dehydroepiandrosterone and related hydroxysteroids via 7alpha-hydroxylation

711775

physiological function

6 entries

additional information

2 entries

physiological function

Mus musculus

Q60991

activity towards 5alpha-androstane-3alpha,17beta-diol is very low or undetectable in livers of Cyp7b1(-/-) knockout mice. CYP7B1-mediated catalysis may play a role for control of the cellular levels of androgens, not only of estrogens

702427

physiological function

Sus scrofa

-

CYP7B1-mediated catalysis may play a role for control of the cellular levels of androgens, not only of estrogens

702427

physiological function

Homo sapiens

O75881

CYP7B1-mediated catalysis may play a role for control of the cellular levels of androgens, not only of estrogens

702427

physiological function

Homo sapiens

-

important role for CYP7B1 in cellular growth, particularly in connection with estrogenic signalling

705397

physiological function

Mesocricetus auratus

-

key enzyme in bile acid synthesis by the alternative pathway

695480

physiological function

Mus musculus

-

pregnane X receptor activation significantly regulates genes in the liver involved in lipoprotein transportation and cholesterol metabolism, including CYP39A1, in both wild-type and ApoE-/- mice

705003

additional information

Homo sapiens

O75881

spastic paraplegia type 5, SPG5, is caused by mutations in CYP7B1, a gene encoding the cytochrome P-450 oxysterol 7-alpha-hydroxylase, CYP7B1, an enzyme implicated in cholesterol metabolism. Mutations in CYP7B1 are found in both pure and complicated forms of the disease, clinical phenotypes, overview

711775

additional information

Homo sapiens

-

spastic paraplegia type 5, SPG5, is caused by mutations in CYP7B1, a gene encoding the cytochrome P-450 oxysterol 7-alpha-hydroxylase, CYP7B1, an enzyme implicated in cholesterol metabolism. Mutations in CYP7B1 are found in both pure and complicated forms of the disease, clinical phenotypes, overview

711775