1.14.14.29: 25/26-hydroxycholesterol 7alpha-hydroxylase
This is an abbreviated version!
For detailed information about 25/26-hydroxycholesterol 7alpha-hydroxylase, go to the full flat file.
Word Map on EC 1.14.14.29
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1.14.14.29
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oxysterols
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bile
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cyp27a1
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27-hydroxycholesterol
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paraplegia
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dehydroepiandrosterone
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neurosteroids
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7alpha-hydroxylation
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27-hydroxylase
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interferon-stimulated
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lithogenic
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cholesterol-25-hydroxylase
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7alpha-hydroxy-dhea
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5alpha-androstane-3beta,17beta-diol
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7-hydroxylation
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cyp2b9
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medicine
- 1.14.14.29
- oxysterols
- bile
- cyp27a1
- 27-hydroxycholesterol
- paraplegia
- dehydroepiandrosterone
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neurosteroids
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7alpha-hydroxylation
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27-hydroxylase
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interferon-stimulated
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lithogenic
- cholesterol-25-hydroxylase
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7alpha-hydroxy-dhea
- 5alpha-androstane-3beta,17beta-diol
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7-hydroxylation
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cyp2b9
- medicine
Reaction
Synonyms
25-hydroxycholesterol 7alpha-hydroxylase, 25-hydroxycholesterol 7alpha-monooxygenase, 25-hydroxycholesterol-7alpha-hydroxylase, cholesterol 25-hydroxylase, Cyp39a1, CYP7B, CYP7B1, CYP7B1 oxysterol 7alpha-hydroxylase, CYPB1, cytochome P450 7B1, cytochrome P-450 oxysterol 7-alpha-hydroxylase, EC 1.14.13.100, EC 1.14.13.60, oxysterol 7 alpha-hydroxylase, oxysterol 7alpha-hydroxylase, oxysterol-7alpha-hydroxylase, Steroid hydroxylase
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General Information
General Information on EC 1.14.14.29 - 25/26-hydroxycholesterol 7alpha-hydroxylase
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metabolism
CYP7B1 is an enzyme expressed in many human tissues and implicated in cholesterol metabolism. In the liver, this protein is part of the alternate/acidic pathway for primary bile acid production while in brain, CYP7B1 provides the primary metabolic route for cholesterol derivatives dehydroepiandrosterone and related hydroxysteroids via 7alpha-hydroxylation
physiological function
additional information
activity towards 5alpha-androstane-3alpha,17beta-diol is very low or undetectable in livers of Cyp7b1(-/-) knockout mice. CYP7B1-mediated catalysis may play a role for control of the cellular levels of androgens, not only of estrogens
physiological function
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CYP7B1-mediated catalysis may play a role for control of the cellular levels of androgens, not only of estrogens
physiological function
CYP7B1-mediated catalysis may play a role for control of the cellular levels of androgens, not only of estrogens
physiological function
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important role for CYP7B1 in cellular growth, particularly in connection with estrogenic signalling
physiological function
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key enzyme in bile acid synthesis by the alternative pathway
physiological function
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pregnane X receptor activation significantly regulates genes in the liver involved in lipoprotein transportation and cholesterol metabolism, including CYP39A1, in both wild-type and ApoE-/- mice
spastic paraplegia type 5, SPG5, is caused by mutations in CYP7B1, a gene encoding the cytochrome P-450 oxysterol 7-alpha-hydroxylase, CYP7B1, an enzyme implicated in cholesterol metabolism. Mutations in CYP7B1 are found in both pure and complicated forms of the disease, clinical phenotypes, overview
additional information
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spastic paraplegia type 5, SPG5, is caused by mutations in CYP7B1, a gene encoding the cytochrome P-450 oxysterol 7-alpha-hydroxylase, CYP7B1, an enzyme implicated in cholesterol metabolism. Mutations in CYP7B1 are found in both pure and complicated forms of the disease, clinical phenotypes, overview