1.14.14.29: 25/26-hydroxycholesterol 7alpha-hydroxylase

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For detailed information about 25/26-hydroxycholesterol 7alpha-hydroxylase, go to the full flat file.

Reaction

Synonyms

25-hydroxycholesterol 7alpha-hydroxylase, 25-hydroxycholesterol 7alpha-monooxygenase, 25-hydroxycholesterol-7alpha-hydroxylase, cholesterol 25-hydroxylase, Cyp39a1, CYP7B, CYP7B1, CYP7B1 oxysterol 7alpha-hydroxylase, CYPB1, cytochome P450 7B1, cytochrome P-450 oxysterol 7-alpha-hydroxylase, EC 1.14.13.100, EC 1.14.13.60, oxysterol 7 alpha-hydroxylase, oxysterol 7alpha-hydroxylase, oxysterol-7alpha-hydroxylase, Steroid hydroxylase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.14.29 25/26-hydroxycholesterol 7alpha-hydroxylase

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Results	in table
1	Activating Compound
4	AA Sequence
1	Application
2	CAS Registry Number
6	Cloned(Commentary)
19	Cofactor
391	Disease/ Diagnostics
3	Expression
8	General Information
13	Inhibitors
2	Ki Value [mM]
7	KM Value [mM]
8	Localization
2	Molecular Weight [Da]
12	Natural Substrates/ Products (Substrates)
31	Organism
2	Pathway
8	Protein Variants
4	Reaction
3	Reaction Type
30	Reference
38	Source Tissue
46	Substrates and Products (Substrate)
2	Subunits
45	Synonyms
1	Systematic Name
2	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 1.14.14.29 - 25/26-hydroxycholesterol 7alpha-hydroxylase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

estrogen

Homo sapiens

-

overexpression of PI3K or Akt significantly increases estrogenic upregulation of CYP7B1 in Hep-G2 cells. Estrogen receptor interacts with the PI3K/Akt pathway without binding to the CYP7B1 gene. In HEK293 cells, CYP7B1 transcription is much less affected by Akt, indicating that the mechanism for upregulation of CYP7B1 is different in different cell types

705397