1.14.14.25: cholesterol 24-hydroxylase
This is an abbreviated version!
For detailed information about cholesterol 24-hydroxylase, go to the full flat file.
Word Map on EC 1.14.14.25
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1.14.14.25
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alzheimer
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24s-hydroxycholesterol
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oxysterols
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cyp27a1
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efavirenz
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24-hydroxylation
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medicine
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27-hydroxylase
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24s-ohc
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epsilon4
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lathosterol
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desmosterol
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cholesterol-metabolizing
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drug development
- 1.14.14.25
- alzheimer
- 24s-hydroxycholesterol
- oxysterols
- cyp27a1
- efavirenz
-
24-hydroxylation
- medicine
-
27-hydroxylase
-
24s-ohc
-
epsilon4
- lathosterol
- desmosterol
-
cholesterol-metabolizing
- drug development
Reaction
Synonyms
24S-hydroxylase, CH24H, cholesterol 24-hydroxylase, cholesterol 24-monooxygenase, cholesterol 24S hydroxylase, cholesterol 24S-hydroxylase, cholesterol hydroxylase, cholesterol-24S-hydroxylase, CYP46, CYP46A, CYP46A1, cytochrome P-450 46A1, cytochrome P450 46A1, cytochrome P450 cholesterol 24-hydroxylase, EC 1.14.13.98
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Inhibitors
Inhibitors on EC 1.14.14.25 - cholesterol 24-hydroxylase
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(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)[8-(1,3-oxazol-5-yl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]methanone
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(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)[8-(1,3-oxazol-5-yl)-6-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]methanone
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1-[3-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-8-yl]-4H-1,2,4-triazol-1-ium
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2-[5-methyl-1-(pyridine-4-carbonyl)-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-3-yl]benzonitrile
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8-(1,3-oxazol-5-yl)-N-phenyl-6-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxamide
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N-benzyl-8-(1,3-oxazol-5-yl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxamide
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siRNA
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reduction of the cholesterol 24-hydroxylase, which results in lower levels of Trk phosphorylation
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[6-cyclopropyl-8-(1,3-oxazol-5-yl)imidazo[1,2-a]pyridin-3-yl](3-oxa-8-azabicyclo[3.2.1]octan-8-yl)methanone
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[6-fluoro-8-(1,3-oxazol-5-yl)imidazo[1,2-a]pyridin-3-yl](3-oxa-8-azabicyclo[3.2.1]octan-8-yl)methanone
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additional information
generation of a series of imidazo[1,2-a]pyridine analogues that effectively inhibit cholesterol 24-hydroxylase (CYP46A1), synthesis and evaluation, overview
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binds with high affinity to CYP46A1 in vitro and efficiently inhibits CYP46A1-catalyzed cholesterol hydroxylations in the reconstituted system
voriconazole
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voriconazole-induced visual disturbances related to an interaction between the drug and retinal CYP46A1
voriconazole
voriconazole decreases 24S-hydroxycholesterol levels in the retina. CYP46A1 expression is increased in the retina of voriconazole-treated rats. Intercellular adhesion molecule 1 (ICAM-1) and monocyte chemotactic protein 1 (MCP-1) show significant increases in the retina and vitreous body. Minocycline did not reverse the effects of voriconazole