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1.14.14.24: vitamin D 25-hydroxylase

This is an abbreviated version!
For detailed information about vitamin D 25-hydroxylase, go to the full flat file.

Word Map on EC 1.14.14.24

Reaction

calciol
+
O2
 +
[reduced NADPH-hemoprotein reductase]
=
calcidiol
 +
[oxidized NADPH-hemoprotein reductase]
 +
H2O

Synonyms

CYP2R1, CYP24A1, CYP2C11, CYP2D25, CYP2J3, CYP2R1, CYPIIJ3, Cytochrome P450 2C11, cytochrome P450 2J2, Cytochrome P450 2J3, cytochrome P450 2R1, EC 1.14.13.159, VDH, vitamin D 25-hydroxylase, vitamin D-25-hydroxylase, vitamin D2 25-hydroxylase, vitamin D3 25-hydroxylase, vitamin D3 hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.24 vitamin D 25-hydroxylase

Reference

topprint

Reference on EC 1.14.14.24 - vitamin D 25-hydroxylase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rahmaniyan, M.; Patrick, K.; Bell, N.H.
Characterization of recombinant CYP2C11: a vitamin D 25-hydroxylase and 24-hydroxylase
Am. J. Physiol. Endocrinol. Metab.
288
E753-E760
2005
Rattus norvegicus (P08683)
Manually annotated by BRENDA team
Postlind, H.; Axen, E.; Bergman, T.; Wikvall, K.
Cloning, structure, and expression of a cDNA encoding vitamin D3 25-hydroxylase
Biochem. Biophys. Res. Commun.
241
491-497
1997
Sus scrofa
Manually annotated by BRENDA team
Hosseinpour, F.; Hidestrand, M.; Ingelman-Sundberg, M.; Wikvall, K.
The importance of residues in substrate recognition site 3 for the catalytic function of CYP2D25 (vitamin D 25-hydroxylase)
Biochem. Biophys. Res. Commun.
288
1059-1063
2001
Sus scrofa
Manually annotated by BRENDA team
Shinkyo, R.; Sakaki, T.; Kamakura, M.; Ohta, M.; Inouye, K.
Metabolism of vitamin D by human microsomal CYP2R1
Biochem. Biophys. Res. Commun.
324
451-457
2004
Homo sapiens
Manually annotated by BRENDA team
Fujii, Y.; Kabumoto, H.; Nishimura, K.; Fujii, T.; Yanai, S.; Takeda, K.; Tamura, N.; Arisawa, A.; Tamura, T.
Purification, characterization, and directed evolution study of a vitamin D3 hydroxylase from Pseudonocardia autotrophica
Biochem. Biophys. Res. Commun.
385
170-175
2009
Pseudonocardia autotrophica (C4B644), Pseudonocardia autotrophica NBRC 12743 (C4B644)
Manually annotated by BRENDA team
Saarem, K.; Pedersen, J.I.
25-Hydroxylation of 1 alpha-hydroxyvitamin D-3 in rat and human liver
Biochim. Biophys. Acta
840
117-126
1985
Rattus norvegicus
Manually annotated by BRENDA team
Axen, E.
Purification from pig kidney of a microsomal cytochrome P450 catalyzing 1 alpha-hydroxylation of 25-hydroxyvitamin D3
FEBS Lett.
375
277-279
1995
Sus scrofa
Manually annotated by BRENDA team
Masumoto, O.; Ohyama, Y.; Okuda, K.
Purification and characterization of vitamin D 25-hydroxylase from rat liver mitochondria
J. Biol. Chem.
263
14256-14260
1988
Rattus norvegicus
Manually annotated by BRENDA team
Cheng, J.B.; Motola, D.L.; Mangelsdorf, D.J.; Russell, D.W.
De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase
J. Biol. Chem.
278
38084-38093
2003
Mus musculus (Q6VVW9)
Manually annotated by BRENDA team
Yamasaki, T.; Izumi, S.; Ide, H.; Ohyama, Y.
Identification of a novel rat microsomal vitamin D3 25-hydroxylase
J. Biol. Chem.
279
22848-22856
2004
Rattus norvegicus (P51590)
Manually annotated by BRENDA team
Kaufmann, M.; Prosser, D.E.; Jones, G.
Bioengineering anabolic vitamin D-25-hydroxylase activity into the human vitamin D catabolic enzyme, cytochrome P450 CYP24A1, by a V391L mutation
J. Biol. Chem.
286
28729-28737
2011
Homo sapiens (Q07973), Homo sapiens
Manually annotated by BRENDA team
Strushkevich, N.; Usanov, S.A.; Plotnikov, A.N.; Jones, G.; Park, H.W.
Structural analysis of CYP2R1 in complex with vitamin D3
J. Mol. Biol.
380
95-106
2008
Homo sapiens (Q6VVX0)
Manually annotated by BRENDA team
Cheng, J.B.; Levine, M.A.; Bell, N.H.; Mangelsdorf, D.J.; Russell, D.W.
Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase
Proc. Natl. Acad. Sci. USA
101
7711-7715
2004
Homo sapiens
Manually annotated by BRENDA team
Wang, Y.; Marling, S.J.; Zhu, J.G.; Severson, K.S.; DeLuca, H.F.
Development of experimental autoimmune encephalomyelitis (EAE) in mice requires vitamin D and the vitamin D receptor
Proc. Natl. Acad. Sci. USA
109
8501-8504
2012
Mus musculus
Manually annotated by BRENDA team
Aiba, I.; Yamasaki, T.; Shinki, T.; Izumi, S.; Yamamoto, K.; Yamada, S.; Terato, H.; Ide, H.; Ohyama, Y.
Characterization of rat and human CYP2J enzymes as Vitamin D 25-hydroxylases
Steroids
71
849-856
2006
Homo sapiens (P51589), Homo sapiens, Rattus norvegicus (P51590)
Manually annotated by BRENDA team
Urbschat, A.; Paulus, P.; von Quernheim, Q.F.; Brueck, P.; Badenhoop, K.; Zeuzem, S.; Ramos-Lopez, E.
Vitamin D hydroxylases CYP2R1, CYP27B1 and CYP24A1 in renal cell carcinoma
Eur. J. Clin. Invest.
43
1282-1290
2013
Homo sapiens (Q6VVX0)
Manually annotated by BRENDA team
Foresta, C.; Strapazzon, G.; De Toni, L.; Perilli, L.; Di Mambro, A.; Muciaccia, B.; Sartori, L.; Selice, R.
Bone mineral density and testicular failure: evidence for a role of vitamin D 25-hydroxylase in human testis
J. Clin. Endocrinol. Metab.
96
E646-E652
2011
Homo sapiens (Q6VVX0), Homo sapiens
Manually annotated by BRENDA team
Nissen, J.; Vogel, U.; Ravn-Haren, G.; Andersen, E.W.; Madsen, K.H.; Nex?, B.A.; Andersen, R.; Mejborn, H.; Bjerrum, P.J.; Rasmussen, L.B.; Wulf, H.C.
Common variants in CYP2R1 and GC genes are both determinants of serum 25-hydroxyvitamin D concentrations after UVB irradiation and after consumption of vitamin D3-fortified bread and milk during winter in Denmark
Am. J. Clin. Nutr.
101
218-227
2015
Homo sapiens (Q6VVX0)
Manually annotated by BRENDA team
Yasuda, K.; Endo, M.; Ikushiro, S.; Kamakura, M.; Ohta, M.; Sakaki, T.
UV-dependent production of 25-hydroxyvitamin D2 in the recombinant yeast cells expressing human CYP2R1
Biochem. Biophys. Res. Commun.
434
311-315
2013
Homo sapiens (Q6VVX0), Homo sapiens
Manually annotated by BRENDA team
De Toni, L.; De Filippis, V.; Tescari, S.; Ferigo, M.; Ferlin, A.; Scattolini, V.; Avogaro, A.; Vettor, R.; Foresta, C.
Uncarboxylated osteocalcin stimulates 25-hydroxy vitamin D production in Leydig cell line through a GPRC6a-dependent pathway
Endocrinology
155
4266-4274
2014
Mus musculus (Q6VVW9), Mus musculus
Manually annotated by BRENDA team
Sundaram, K.; Sambandam, Y.; Tsuruga, E.; Wagner, C.L.; Reddy, S.V.
1alpha,25-dihydroxyvitamin D3 modulates CYP2R1 gene expression in human oral squamous cell carcinoma tumor cells
Horm. Cancer
5
90-97
2014
Homo sapiens (Q6VVX0), Homo sapiens
Manually annotated by BRENDA team
Zhu, J.G.; Ochalek, J.T.; Kaufmann, M.; Jones, G.; Deluca, H.F.
CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in vivo
Proc. Natl. Acad. Sci. USA
110
15650-15655
2013
Mus musculus (Q6VVW9), Mus musculus C57BL/6 (Q6VVW9)
Manually annotated by BRENDA team
Ahn, J.; Yu, K.; Stolzenberg-Solomon, R.; Simon, K.C.; McCullough, M.L.; Gallicchio, L.; Jacobs, E.J.; Ascherio, A.; Helzlsouer, K.; Jacobs, K.B.; Li, Q.; Weinstein, S.J.; Purdue, M.; Virtamo, J.; Horst, R.; Wheeler, W.; Chanock, S.; Hunter, D.J.; Hayes, R.B.; Kraft, P.; Albanes, D.
Genome-wide association study of circulating vitamin D levels
Hum. Mol. Genet.
19
2739-2745
2010
Homo sapiens (Q6VVX0), Homo sapiens
Manually annotated by BRENDA team