1.14.14.24: vitamin D 25-hydroxylase
This is an abbreviated version!
For detailed information about vitamin D 25-hydroxylase, go to the full flat file.
Word Map on EC 1.14.14.24
-
1.14.14.24
-
25-hydroxyvitamin
-
cyp27b1
-
cyp2j2
-
arachidonic
-
25-hydroxylation
-
epoxyeicosatrienoic
-
epoxygenase
-
rickets
-
d-related
-
male-specific
-
7-dehydrocholesterol
-
cholecalciferol
-
astemizole
-
ebastine
-
terfenadine
-
d-associated
-
medicine
-
1alpha-hydroxylation
- 1.14.14.24
-
25-hydroxyvitamin
- cyp27b1
- cyp2j2
-
arachidonic
-
25-hydroxylation
-
epoxyeicosatrienoic
- epoxygenase
- rickets
-
d-related
-
male-specific
- 7-dehydrocholesterol
- cholecalciferol
- astemizole
- ebastine
- terfenadine
-
d-associated
- medicine
-
1alpha-hydroxylation
Reaction
Synonyms
CYP2R1, CYP24A1, CYP2C11, CYP2D25, CYP2J3, CYP2R1, CYPIIJ3, Cytochrome P450 2C11, cytochrome P450 2J2, Cytochrome P450 2J3, cytochrome P450 2R1, EC 1.14.13.159, VDH, vitamin D 25-hydroxylase, vitamin D-25-hydroxylase, vitamin D2 25-hydroxylase, vitamin D3 25-hydroxylase, vitamin D3 hydroxylase
ECTree
Advanced search results
Expression
Expression on EC 1.14.14.24 - vitamin D 25-hydroxylase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
1alpha,25-dihydroxyvitamin D3 increases CYP2R1 gene and and vitamin D receptor mRNA expression in human oral squamous cell carcinoma tumor cells. JNK inhibitor suppresses 1,25 (OH)2D3 stimulation of hCYP2R1 gene promoter activity compared to unstimulated cells
CYP2J3 mRNA is is expressed at a level similar to that of CYP27A1 without marked sexual dimorphism
genes CYP2R1 encoding vitamin D 25-hydroxylase, CYP27B1 encoding 25-hydroxyvitamin D-1 alpha hydroxylase and CYP24A1 encoding 1,25-dihydroxyvitamin D(3) 24-hydroxylase are upregulated in clear cell renal cell carcinomas compared with normal tissue. CYP24A1 displays a significantly higher expression in tumours than CYP27B1 and CYP2R1, whereas no differences in the expression of these genes are found in healthy renal tissue
in male rats, hepatic microsomal CYP2C11 mRNA is decreased by 73% upon hypophysectomy
the luteinizing hormone induces the enzyme. MA-10 cell stimulation with either human chorionic gonadotropin or uncarboxylated-osteocalcin increases CYP2R1 protein expression in a dose-dependent manner and, in turn, increases the release of 25-hydroxy-vitamin D in culture medium. Osteocalcin, in particular uncarboxylated osteocalcin, stimulates 25-hydroxylation of vitamin D in Leydig cells through a direct effect on the expression of the main actor in the 25-hydroxylase activity of vitamin D, the CYP2R1 protein