1.14.14.23: cholesterol 7alpha-monooxygenase
This is an abbreviated version!
For detailed information about cholesterol 7alpha-monooxygenase, go to the full flat file.
Word Map on EC 1.14.14.23
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1.14.14.23
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lipoprotein
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hepatocytes
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triglyceride
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biliary
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hmg-coa
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farnesoid
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fecal
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low-density
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hypercholesterolemia
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cholic
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high-fat
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chenodeoxycholic
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3-hydroxy-3-methylglutaryl
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ba
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cyp8b1
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cholestyramine
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enterohepatic
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cholestasis
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hdl
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gallstone
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hypocholesterolemic
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27-hydroxylase
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oxysterols
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cholesteryl
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hmgcr
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cyp27a1
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taurocholate
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cholesterol-lowering
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hypolipidemic
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ldl-cholesterol
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acyl-coa:cholesterol
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27-hydroxycholesterol
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alpha-hydroxylation
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lithogenic
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ursodeoxycholic
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lxralpha
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hnf4alpha
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cyp3a11
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sult2a1
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4alpha
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cholesterogenesis
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gut-liver
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npc1l1
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cholesterol-free
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srebp2
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ldl-receptor
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c1-like
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medicine
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analysis
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obeticholic
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cholestanol
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guggulsterone
- 1.14.14.23
- lipoprotein
- hepatocytes
- triglyceride
- biliary
- hmg-coa
-
farnesoid
-
fecal
-
low-density
- hypercholesterolemia
-
cholic
-
high-fat
-
chenodeoxycholic
-
3-hydroxy-3-methylglutaryl
- ba
- cyp8b1
- cholestyramine
-
enterohepatic
- cholestasis
- hdl
- gallstone
-
hypocholesterolemic
-
27-hydroxylase
- oxysterols
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cholesteryl
- hmgcr
- cyp27a1
- taurocholate
-
cholesterol-lowering
-
hypolipidemic
-
ldl-cholesterol
-
acyl-coa:cholesterol
- 27-hydroxycholesterol
-
alpha-hydroxylation
-
lithogenic
-
ursodeoxycholic
-
lxralpha
-
hnf4alpha
- cyp3a11
- sult2a1
- 4alpha
-
cholesterogenesis
-
gut-liver
-
npc1l1
-
cholesterol-free
-
srebp2
-
ldl-receptor
-
c1-like
- medicine
- analysis
-
obeticholic
- cholestanol
-
guggulsterone
Reaction
Synonyms
7alpha-hydroxylase, bile acid-synthetic enzyme, C7alphaOH, cholesterol 7 alpha-hydroxylase, cholesterol 7-alpha hydroxylase, Cholesterol 7-alpha-hydroxylase, Cholesterol 7-alpha-monooxygenase, cholesterol 7a-hydroxylase, cholesterol 7alpha hydroxylase, cholesterol 7alpha-hydroxylase, cholesterol-NADPH oxidoreductase, 7alpha-hydroxylating, CYP125A4, CYP7A, CYP7A1, Cyp7alpha1, CYPVII, cytochrome P450 125A4, EC 1.14.13.17, hepatic cholesterol 7alpha-hydroxylase, More, oxygenase, cholesterol 7alpha-mono-
ECTree
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Source Tissue
Source Tissue on EC 1.14.14.23 - cholesterol 7alpha-monooxygenase
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Mycobacterium smegmatis can grow on cholesterol as the sole carbon source
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HepG2 cell transformed with a cyp7alpha-reporter gene (promoter fragment fused to firefly luciferase)
additional information
enzyme expression analysis, increased levels of Cyp7a1/CYP7A1 mRNA in human hepatocytes treated with 1alpha,25-dihydroxyvitamin D3
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different catechins, (-)-epicatechin gallate, (-)-epigallocatechin-3-gallate, (-)-epigallocatechin and (-)-epicatechin, up-regulates the CYP7A1 mRNA level by 5.5-, 4.2-, 2.9- and 1.9-fold, respectively, compared with the control
importance of histone deacetylases in the feedback regulation of CYP7A1 transcription
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HepG2 cell transformed with a cyp7alpha-reporter gene (promoter fragment fused to firefly luciferase)
primary, CYP7A1 expression analysis in absence or presence of isnulin
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wheat antioxidants significantly up-regulate the mRNA of cholesterol 7alpha-hydroxylase, the key enzyme for cholesterol metabolism, in primary rat hepatocytes
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Cyp7a1 expression pattern in wild-type and Cyp8b1 null mice livers, Cyp7a1 expression in wild type mice shows a zonal distribution pattern, Cyp8b1 knockout mice show increased expression of Cyp7a1, overview
expression profile of the Cyp7a transcript in wild-type mice shows a strong circadian rhythm in both the 12L:12D light-dark cycle and constant darkness. In Clock/Clock mutant mice expression profile of the Cyp7a transcript also exhibits a circadian rhythm at an enhanced level with a lower amplitude, although its protein level becomes arrhythmic at a high level. Active CLOCK is essential for the robust circadian expression of Cyp7a. Clock-controlled genes - DBP, DEC2, and REV-ERBalpha/beta are direct regulators required for the robust circadian rhythm of Cyp7a. The circadian rhythm of Cyp7a is regulated by multiple transcription factors, including DBP, REV-ERBalpha/beta, LXRalpha, HNF4alpha DEC2, E4BP4, and PPARalpha
distribution of vitamin D receptor and enzyme proteins in the liver by immunostaining, overview
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distribution of vitamin D receptor and enzyme proteins in the liver by immunostaining, overview
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285296, 285297, 285298, 285300, 285302, 285303, 285304, 285305, 285306, 285307, 285308, 285309, 285314, 659666, 695473, 699703, 700572, 712117
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enzyme activity during liver regeneration after hepatectomy, 7alpha-hydroxylase activities recover after day 3 and are not reduced on days 3, 5, or 7 compared to those of sham-operated rats
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chlorella powder or cholesterol + bile acid increases enzyme activity significantly
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the cyp7A1 gene plays an important role in development of hypercholesterolemia in PHHC rats
enzyme expression analysis in mice fed normal or Western diets for 3 weeks and then given intraperitoneal injections of vehicle (corn oil) or 1alpha,25-dihydroxyvitamin D3 in 4 doses of 0.0025 mg/kg, every other day. Increased levels of Cyp7a1/CYP7A1 mRNA in mouse hepatocytes treated with 1alpha,25-dihydroxyvitamin D3
additional information
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enzyme expression analysis in mice fed normal or Western diets for 3 weeks and then given intraperitoneal injections of vehicle (corn oil) or 1alpha,25-dihydroxyvitamin D3 in 4 doses of 0.0025 mg/kg, every other day. Increased levels of Cyp7a1/CYP7A1 mRNA in mouse hepatocytes treated with 1alpha,25-dihydroxyvitamin D3
additional information
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enzyme expression analysis in mice fed normal or Western diets for 3 weeks and then given intraperitoneal injections of vehicle (corn oil) or 1alpha,25-dihydroxyvitamin D3 in 4 doses of 0.0025 mg/kg, every other day. Increased levels of Cyp7a1/CYP7A1 mRNA in mouse hepatocytes treated with 1alpha,25-dihydroxyvitamin D3
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additional information
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enzyme activity in rats of different strains and with different sexes, the enzyme is upregulated in both female and male Nagase analbuminemic rats compared to Sprague-Dawley rats, overview
additional information
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Cyp7a1 and the bile acid pool size are increased 2-3fold in lactating postpartum rats, the regulatory mechanism functions via altered interaction of nuclear receptors with the Cyp7a1 proximal promoter and altered expression of regulatory signaling pathways in postpartum rats at day 10
additional information
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enzyme activity in rats of different strains and with different sexes, the enzyme is upregulated in both female and male Nagase analbuminemic rats compared to Sprague-Dawley rats, overview
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