1.14.14.17: squalene monooxygenase

This is an abbreviated version!
For detailed information about squalene monooxygenase, go to the full flat file.

Word Map on EC 1.14.14.17

1.14.14.17

cholesterol

sterol

terbinafine

ergosterol

trichophyton

mevalonate

lanosterol

allylamine

2,3-oxidosqualene

hmg-coa

itraconazole

mentagrophytes

rubrum

oxidosqualene

terbinafine-resistant

tellurium

tinea

naftifine

interdigitale

antimycotic

bloch

griseofulvin

dammarenediol

dermatophytoses

cycloartenol

beta-amyrin

medicine

corporis

drug development

nutrition

biotechnology

pharmacology

cholesterogenic

synthesis

Reaction

Synonyms

CYP17, cytochrome P450 17alpha hydroxylase/17,20 lyase, EC 1.14.13.132, EC 1.14.99.7, Erg1, Erg1 protein, Erg1p, hydroxylase, squalene, oxygenase, squalene mono-, PgSQE1, PgSQE2, SE, SE1, SE3, SQE, SQE-I, SQE-II, sqe1, SQE3, SQLE, squalen expoxidase, squalene 2,3-epoxidase, squalene 2,3-oxidocyclase, squalene epoxidase, squalene epoxidase 1, squalene epoxidase 3, squalene hydroxylase, squalene mono-oxygenase, squalene oxydocyclase, squalene-2,3-epoxidase, squalene-2,3-epoxide cyclase, TkSQE1, TkSQE2, TkSQE3, TkSQE4

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.14.17 squalene monooxygenase

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Results	in table
15	Activating Compound
4611	AA Sequence
9	Application
1	CAS Registry Number
32	Cloned(Commentary)
41	Cofactor
2	Crystallization (Commentary)
167	Disease/ Diagnostics
14	Expression
22	General Information
2	General Stability
4	IC50 Value
154	Inhibitors
15	Ki Value [mM]
21	KM Value [mM]
27	Localization
1	Metals/Ions
16	Molecular Weight [Da]
28	Natural Substrates/ Products (Substrates)
154	Organism
7	Pathway
6	PDB ID
8	pH Optimum
7	pI Value
71	Protein Variants
15	Purification (Commentary)
5	Reaction
4	Reaction Type
81	Reference
2	Renatured (Commentary)
69	Source Tissue
8	Specific Activity [micromol/min/mg]
5	Storage Stability
71	Substrates and Products (Substrate)
18	Subunits
83	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
6	Turnover Number [1/s]

KI Value

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KI Value on EC 1.14.14.17 - squalene monooxygenase

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0.00074

(-)-epigallocatechin-3-O-gallate

Rattus norvegicus

37°C, pH 7.4

438210

0.00003 - 0.077

(E)-N-(6,6-dimethylhept-2-en-4-ynyl)-N-methyl-1-naphthalenemethaneamine hydrochloride

3 entries

0.00034 - 1.44

(E)-N-methyl-N-(3-phenylprop-2-enyl)-1-naphthalenemethaneamine

3 entries

0.00074

epigallocatechin-3-O-gallate

Rattus norvegicus

non-competitive, non-time dependent inhibition

438210

0.00000041 - 0.0087

NB-598

2 entries

0.000075

terbinafine

Saccharomyces cerevisiae

438205

0.004

tris norsqualene alcohol

Sus scrofa

pH and temperature not specified in the publication

735203

0.002

tris norsqualene cyclopropylamine

Sus scrofa

pH and temperature not specified in the publication

735203

0.0184

trisnorsqualene alcohol diazoester

Rattus norvegicus

recombinant truncated enzyme mutant, pH 7.4, 37°C

657764

additional information

Rattus norvegicus

inhibition kinetics

657764