1.14.14.15: (3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] monooxygenase

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For detailed information about (3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] monooxygenase, go to the full flat file.

Reaction

(3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2]

Synonyms

SgcC, SgcC3, SgcE6

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.14.15 (3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] monooxygenase

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Results	in table
1	AA Sequence
2	Cloned(Commentary)
1	Cofactor
1	Crystallization (Commentary)
1	General Information
1	kcat/KM [mM/s]
1	KM Value [mM]
1	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
4	Organism
3	Pathway
1	pH Optimum
1	pH Range
2	Purification (Commentary)
1	Reaction
4	Reference
15	Substrates and Products (Substrate)
1	Subunits
4	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Turnover Number [1/s]

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Reference on EC 1.14.14.15 - (3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] monooxygenase

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725188

Lin, S.; van Lanen, S.G., Shen, B.

Regiospecific chlorination of (S)-beta-tyrosyl-S-carrier protein catalyzed by SgcC3 in the biosynthesis of the enediyne antitumor antibiotic C-1027

J. Am. Chem. Soc.

129

12432-12438

2007

Streptomyces globisporus

17887753

725192

Lin, S.; Van Lanen, S.G.; Shen, B.

Characterization of the two-component, FAD-dependent monooxygenase SgcC that requires carrier protein-tethered substrates for the biosynthesis of the enediyne antitumor antibiotic C-1027

J. Am. Chem. Soc.

130

6616-6623

2008

Streptomyces globisporus

18426211

729877

Van Lanen, S.G.; Dorrestein, P.C.; Christenson, S.D.; Liu, W.; Ju, J.; Kelleher, N.L.; Shen, B.

Biosynthesis of the beta-amino acid moiety of the enediyne antitumor antibiotic C-1027 featuring beta-amino acyl-S-carrier protein intermediates

J. Am. Chem. Soc.

127

11594-11595

2005

Streptomyces globisporus

16104723

744358

Chang, C.; Lohman, J.; Cao, H.; Tan, K.; Rudolf, J.; Ma, M.; Xu, W.; Bingman, C.; Yennamalli, R.; Bigelow, L.; Babnigg, G.; Yan, X.; Joachimiak, A.; Phillips, G.; Shen, B.

Crystal structures of SgcE6 and SgcC, the two-component monooxygenase that catalyzes hydroxylation of a carrier protein-tethered substrate during the biosynthesis of the enediyne antitumor antibiotic C-1027 in Streptomyces globisporus

Biochemistry

5142-5154

2016

Streptomyces globisporus (Q8GME2 and Q8GMG6)

27560143