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1.14.14.14: aromatase

This is an abbreviated version!
For detailed information about aromatase, go to the full flat file.

Word Map on EC 1.14.14.14

Reaction

19-hydroxyandrost-4-ene-3,17-dione
+
O2
 +
[reduced NADPH-hemoprotein reductase]
=
19-oxo-androst-4-ene-3,17-dione
 + 2 H2O +
[oxidized NADPH-hemoprotein reductase]

Synonyms

AROM, Cyp19a, CYP19A1, Cyp19a1a, Cyp19a1b, Cyp19A3, cytochrome P450 aromatase, P450arom

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.14 aromatase

IC50 Value

IC50 Value on EC 1.14.14.14 - aromatase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0016
(E)-2,4-dimethoxy-N-(4-(phenyldiazenyl)phenyl)benzenesulfonamide
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
-
0.0079
(E)-4-cyano-N-(4-(phenyldiazenyl)phenyl)benzenesulfonamide
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
-
0.0057
(E)-N-((1H-benzo[d]imidazole-2-yl)methyl)-2,4-dimethoxy-N-(4-(phenyldiazenyl)phenyl)benzenesulfonamide
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
-
0.000006
1-(3-bromo-4-methoxybenzene-1-sulfonyl)-3-[(1H-imidazol-1-yl)methyl]piperidine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000009
1-[3-(2-chloro-6-nitrophenyl)benzene-1-sulfonyl]-3-[(1H-imidazol-1-yl)methyl]piperidine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0006
17beta,11alpha-dihydroxy-17alpha-methylandrosta-2-oxa-4-ene-3-one
Homo sapiens
pH 7.4, 37°C
-
0.00305
2-(pyridin-3-yl)-1H-indole
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.00161
2-phenyl-1H-indole-3-carbonitrile
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.000032
3-(4-(1H-benzo[d]imidazol-2-yl)phenyl)-6-(4-cyanophenyl)-7H-[1,2,4]triazole[3,4-b][1,3,4]thiadiazine
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
-
0.00172
3-(4-(1H-benzo[d]imidazol-2-yl)phenyl)-6-(4-fluorophenyl)-7H-[1,2,4]triazole[3,4-b][1,3,4]thiadiazine
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
-
0.00156
3-(4-(5-chloro-1H-benzo[d]imidazol-2-yl)phenyl)-6-(4-cyanophenyl)-7H-[1,2,4]triazole [3,4-b][1,3,4]thiadiazine
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
-
0.00228
3-(4-(5-chloro-1H-benzo[d]imidazol-2-yl)phenyl)-6-(4-fluorophenyl)-7H-[1,2,4]triazole [3,4-b][1,3,4]thiadiazine
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
-
0.000007
4-[3-[(1H-imidazol-1-yl)methyl]piperidine-1-sulfonyl]-2,1,3-benzothiadiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.009
5-nitro-2-phenyl-1H-indole
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.000105
6alpha-allylandrost-4-ene-3,17-dione
Homo sapiens
pH 7.4, 37°C
-
0.000055
6alpha-allylandrosta-1,4-diene-3,17-dione
Homo sapiens
pH 7.4, 37°C
-
0.00017
6alpha-methylandrost-4-en-17-one
Homo sapiens
pH 7.4, 37°C
-
0.00006
6alpha-methylandrost-4-ene-3,17-dione
Homo sapiens
pH 7.4, 37°C
-
0.00006 - 0.00007
7,8-Benzoflavone
0.00011
7alpha-allyl-4-hydroxyandrost-4-ene-3,17-dione
Homo sapiens
pH 7.4, 37°C
-
0.000065
8-prenylnaringenin
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.001 - 0.0012
apigenin
0.0004 - 0.0005
chrysin
0.00005
exemestane
Homo sapiens
pH 7.4, 37°C
0.005 - 0.008
flavanone
0.005 - 0.008
flavone
0.000042
formestane
Homo sapiens
pH 7.4, 37°C
0.00138
ganaxolone
Homo sapiens
pH 7.4, 37°C
-
0.081
isoxanthohumol
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000024
letrozole
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.00081
oxandrolone
Homo sapiens
pH 7.4, 37°C
-
0.01 - 0.012
quercetin
0.08
resveratrol
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.000009
SYN 20028567
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0203
xanthohumol
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication