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1.14.13.92: phenylacetone monooxygenase

This is an abbreviated version!
For detailed information about phenylacetone monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.92

Reaction

phenylacetone
+
NADPH
 +
H+
 +
O2
=
Benzyl acetate
 +
NADP+
 +
H2O

Synonyms

4-hydroxyacetophenone monooxygenase, Baeyer-Villiger monooxygenase, BVMO, EtaA, HAPMO, M-PAMO, More, PAMO, phenylacetone monooxygenase, Tf PAMO

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.92 phenylacetone monooxygenase

Inhibitors

Inhibitors on EC 1.14.13.92 - phenylacetone monooxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,4-dioxane
-
33% inhibition at 10% concentration as co-solvent, 53% inhibition at 30%
2-Octanone
-
substrate inhibition
3-acetyl-NADP+
-
0.5 mM, 50% inhibition
3-amino-NADP+
-
0.05 mM, 74% inhibition
acetone
-
45% inhibition at 10% concentration as co-solvent inpresence of substrate, 93% in absence of substrate
acetonitrile
-
88.5% inhibition at 30% concentration as co-solvent
Benzyl acetate
product inhibition
ethanol
-
45% inhibition at 10% concentration as co-solvent
hexane
-
enzyme activity is markedly reduced at concentrations of hexane below 5% and over 30%
Isopropanol
-
52% inhibition at 30% concentration as co-solvent
methanol
-
40% inhibition at 30% concentration as co-solvent
n-Propanol
-
80% inhibition at 30% concentration as co-solvent
NADP+
product inhibition, remains bound during catalysis
phenylacetone
-
substrate inhibition
additional information
-