1.14.13.69: alkene monooxygenase
This is an abbreviated version!
For detailed information about alkene monooxygenase, go to the full flat file.
Word Map on EC 1.14.13.69
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1.14.13.69
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epoxidation
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xanthobacter
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vinyl
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diiron
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nocardioides
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4-monooxygenase
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propyne
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dinuclear
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rhodochrous
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smmos
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epoxygenation
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epoxyethane
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corallinus
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autotrophicus
- 1.14.13.69
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epoxidation
- xanthobacter
-
vinyl
-
diiron
- nocardioides
-
4-monooxygenase
- propyne
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dinuclear
- rhodochrous
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smmos
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epoxygenation
- epoxyethane
- corallinus
- autotrophicus
Reaction
Synonyms
AkMO, alkene epoxygenase, alkene monooxygenase, AMO, ethene MO, EtnABCD, EtnC, etnD, IsoMO, isoprene monooxygenase, More, PmoABCD, propene MO, propene monooxygenase, XAMO
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Metals Ions on EC 1.14.13.69 - alkene monooxygenase
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METALS and IONS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Fe
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ICP-MS analysis of purified IsoABE is used to confirm the presence of the predicted diiron center, presence of 1.12 Fe per monomer, which is lower than the predicted 2 Fe/monomer. Purified IsoMO oxygenase is thus deficient in Fe cofactor and is expected to exhibit decreased activity as a result
Iron
[2Fe-2S]cluster
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the reductase component contains two prosthetic groups, an FAD centre and a [2Fe-2S] cluster. The FAD moiety is reduced by bound NADH in a two-electron reaction. The electrons are then transported to the [2Fe-2S] centre one at a time, which reduces the di-iron centre of the epoxydase. Reduction of the di-iron centre is required for oxygen binding and substrate oxidation
Iron
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the reductase component contains two prosthetic groups, an FAD centre and a [2Fe-2S] cluster. The FAD moiety is reduced by bound NADH in a two-electron reaction. The electrons are then transported to the [2Fe-2S] centre one at a time, which reduces the di-iron centre of the epoxydase. Reduction of the di-iron centre is required for oxygen binding and substrate oxidation
Iron
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the enzyme possesses a dinuclear iron center within the large subunit of the epoxygenase component, AmoC, mutagenesis of AmoC alters the enantioselectivity of the enzyme
Iron
the enzyme is a non-heme diiron monooxygenase and contains a Rieske-type ferredoxin
Iron
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alpha-helical structure that surrounds the binuclear iron binding site
Iron
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enzyme contains 4 components: 1. a monomeric 35500 Da NADH reductase containing 1 mol of FAD and a probable 2Fe-2S center, 2. a 13300 Da ferredoxin containing a Rieske-type 2Fe-2S cluster, 3. a 11000 Da monomeric protein that contains no detectable cofactors, 4. a 212000 Da alpha2beta2gamma2 multimeric protein containing 4 atoms of nonheme iron. The physiological electron acceptor for the reductase is the Rieske-type ferredoxin, which is proposed to be an intermediate electron carrier between the reductase and terminal catalytic component of the system
