1.14.13.54: ketosteroid monooxygenase

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For detailed information about ketosteroid monooxygenase, go to the full flat file.

Reaction

Synonyms

17alpha-Hydroxyprogesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, side-chain cleaving), Androgen hydroxylase, Androstenedione, NADPH2:oxygen oxidoreductase (17-hydroxylating, lactonizing), Baeyer-Villiger monooxygenase, BVMO, CYP106A2, Hydroxylase, steroid, NADPH-dependent steroid Baeyer-Villiger monooxygenase, Oxygenase, steroid mono-, Progesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, ester-producing), Steroid hormone hydroxylase, Steroid hydroxylase, steroid hydroxylating cytochrome, Steroid monooxygenase, Steroid-ketone monooxygenase, STMO

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.13.54 ketosteroid monooxygenase

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Results	in table
1	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
7	Cofactor
1	Crystallization (Commentary)
5	Inhibitors
12	kcat/KM [mM/s]
16	KM Value [mM]
5	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
10	Organism
4	PDB ID
3	pH Optimum
2	pH Range
5	Protein Variants
3	Purification (Commentary)
4	Reaction
2	Reaction Type
8	Reference
1	Renatured (Commentary)
2	Specific Activity [micromol/min/mg]
1	Storage Stability
33	Substrates and Products (Substrate)
5	Subunits
17	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]
6	Turnover Number [1/s]

pH Range

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pH Range on EC 1.14.13.54 - ketosteroid monooxygenase

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

5.5 - 8

Ilyonectria destructans

-

pH 5.5: about 20% of maximal activity, pH 8.0: about 40% of maximal activity, androstenedione monooxygenase activity

7389

6 - 9

Ilyonectria destructans

-

pH 6.0: about 35% of maximal activity, pH 9.0: about 65% of maximal activity, progesterone monooxygenase activity

7390