1.14.13.5: imidazoleacetate 4-monooxygenase

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For detailed information about imidazoleacetate 4-monooxygenase, go to the full flat file.

Reaction

Synonyms

EC 1.14.1.5, imidazoleacetate hydroxylase, imidazoleacetic hydroxylase, imidazoleacetic monooxygenase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.13.5 imidazoleacetate 4-monooxygenase

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Results	in table
1	CAS Registry Number
20	Cofactor
5	Crystallization (Commentary)
30	Inhibitors
16	KM Value [mM]
5	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
6	Organism
4	Pathway
2	pH Optimum
4	Purification (Commentary)
1	Reaction
3	Reaction Type
6	Reference
4	Specific Activity [micromol/min/mg]
4	Storage Stability
22	Substrates and Products (Substrate)
4	Synonyms
1	Systematic Name
4	Temperature Stability [°C]
1	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.14.13.5 - imidazoleacetate 4-monooxygenase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

5-hydroxyindoleacetate

Pseudomonas sp.

-

11% inhibition at 4.5 mM

390101

dihydroxymandelate

Pseudomonas sp.

-

53% inhibition at 4.5 mM

390101

Dihydroxyphenylacetate

Pseudomonas sp.

-

66% inhibition at 4.5 mM

390101

ethyl-mercuric chloride

Pseudomonas sp.

-

-

390105

homogentisate

Pseudomonas sp.

-

50% inhibition at 4.5 mM

390101

homovanillic acid

Pseudomonas sp.

-

5% inhibition at 4.5 mM

390101

Imidazolepyruvate

Pseudomonas sp.

-

56% inhibition at 4.5 mM

390101

indoleacetate

2 entries

m-hydroxyphenylacetate

Pseudomonas sp.

-

79% inhibition at 4.5 mM

390101

mercury compounds

2 entries

-

methyl-mercuric chloride

Pseudomonas sp.

-

-

390105

N-methylimidazoleacetate

Pseudomonas sp.

-

11% inhibition at 4.5 mM

390101

nicotinate

Pseudomonas sp.

-

65% inhibition at 20 mM

390104

p-chloromercuribenzoate

2 entries

p-hydroxybenzoate

Pseudomonas sp.

-

38% inhibition at 4.5 mM

390101

p-hydroxyphenylacetate

Pseudomonas sp.

-

47% inhibition at 4.5 mM

390101

phenyl-mercuric acetate

Pseudomonas sp.

-

-

390105

phenylacetate

2 entries

silver compounds

Pseudomonas sp.

-

-

390103, 390104, 390105

-

Sodium mersalyl

Pseudomonas sp.

-

-

390105

vanillyl mandelic acid

Pseudomonas sp.

-

9% inhibition at 4.5 mM

390101

indoleacetate

Pseudomonas sp.

-

22% inhibition at 4.5 mM

390101

indoleacetate

Pseudomonas sp.

-

30% inhibition at 10 mM

390104

mercury compounds

Pseudomonas sp.

-

-

390103, 390104

-

mercury compounds

Pseudomonas sp.

-

maximum inactivation at a ratio about 2 mol of AgNO3 per mol of enzyme

390105

-

p-chloromercuribenzoate

Pseudomonas sp.

-

-

390102, 390103, 390104

p-chloromercuribenzoate

Pseudomonas sp.

-

maximum inactivation at a ratio about 2 mol of p-chloromercuribenzoate per mol of enzyme

390105

phenylacetate

Pseudomonas sp.

-

25% inhibition at 4.5 mM

390101

phenylacetate

Pseudomonas sp.

-

79% inhibition at 20 mM

390104