1.14.13.35: anthranilate 3-monooxygenase (deaminating)

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For detailed information about anthranilate 3-monooxygenase (deaminating), go to the full flat file.

Reaction

Synonyms

anthranilate 2,3-dioxygenase (deaminating), anthranilate 2,3-hydroxylase (deaminating), anthranilate hydroxylase, anthranilate hydroxylase (deaminating), anthranilic hydroxylase, EC 1.14.12.2

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.13.35 anthranilate 3-monooxygenase (deaminating)

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Results	in table
11	Activating Compound
1	CAS Registry Number
19	Cofactor
4	General Stability
35	Inhibitors
5	KM Value [mM]
4	Metals/Ions
4	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
21	Organism
1	Pathway
7	pH Optimum
3	pH Range
1	pH Stability
6	Purification (Commentary)
5	Reaction
5	Reaction Type
14	Reference
2	Source Tissue
19	Specific Activity [micromol/min/mg]
5	Storage Stability
28	Substrates and Products (Substrate)
2	Subunits
6	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]
1	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.14.13.35 - anthranilate 3-monooxygenase (deaminating)

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

1,10-phenanthroline

4 entries

2,2'-dipyridyl

4 entries

3-hydroxyanthranilic acid

Aspergillus niger

-

-

438877

3-Hydroxybenzoic acid

Aspergillus niger

-

-

438877

8-hydroxyquinoline

3 entries

Cd2+

Aspergillus niger

-

-

438877

Cu2+

Aspergillus niger

-

-

438877

cycloheximide

Aspergillus niger

-

inhibits the enzyme induction

438876

diethyldithiocarbamate

Aspergillus niger

-

-

438875, 438877

EDTA

Aspergillus niger

-

7% inhibition at 1 mM

438873

heavy metal ions

Aspergillus niger

-

-

438875, 438877

-

Hg2+

Aspergillus niger

-

-

438877

N-ethylmaleimide

2 entries

NaN3

2 entries

p-chloromercuribenzoate

Aspergillus niger

-

-

438875

p-hydroxymercuribenzoate

Aspergillus niger

-

96% inhibition at 0.5 mM

438877

Salicylaldoxime

3 entries

additional information

4 entries

-

1,10-phenanthroline

Aspergillus niger

-

50% inhibition at 0.25 mM, 80% inhibition at 0.5 mM and 95% inhibition at 1 mM

438867

1,10-phenanthroline

Aspergillus niger

-

46% inhibition at 0.5 mM , 60% inhibition at 1 mM, 80% inhibition at 3 mM, anthranilic acid protects the enzyme from inhibition

438873

1,10-phenanthroline

Aspergillus niger

-

-

438875

1,10-phenanthroline

Aspergillus niger

-

46% inhibition at 0.5 mM, 60% inhibition at 1 mM

438877

2,2'-dipyridyl

Aspergillus niger

-

50% inhibition at 0.5 mM, 80% inhibition at 1 mM

438867

2,2'-dipyridyl

Aspergillus niger

-

27% inhibition at 0.5 mM, 41% inhibition at 1 mM

438873

2,2'-dipyridyl

Aspergillus niger

-

-

438875

2,2'-dipyridyl

Aspergillus niger

-

40% inhibition at 1 mM

438877

8-hydroxyquinoline

Aspergillus niger

-

30% inhibition at 0.5 mM, 40% inhibition at 1 mM

438867

8-hydroxyquinoline

Aspergillus niger

-

23% inhibition at 0.5 mM, 37% inhibition at 1 mM

438873

8-hydroxyquinoline

Aspergillus niger

-

37% inhibition at 1 mM

438877

N-ethylmaleimide

Aspergillus niger

-

-

438875

N-ethylmaleimide

Aspergillus niger

-

95% inhibition at 0.5 mM

438877

NaN3

Aspergillus niger

-

-

438875

NaN3

Aspergillus niger

-

42% inhibition at 0.5 mM

438877

Salicylaldoxime

Aspergillus niger

-

40% inhibition at 0.5 mM, 52% inhibition at 1 mM

438873

Salicylaldoxime

Aspergillus niger

-

-

438875

Salicylaldoxime

Aspergillus niger

-

42% inhibition at 0.5 mM, 58% inhibition at 1 mM

438877

additional information

Aspergillus niger

-

not: atebrin, aminopterin

438867

-

additional information

Aspergillus niger

-

reversal of 1,10-phenanthroline inhibition by ferric-EDTA, ferrous-EDTA, ferric citrate and cytochrome c

438873

-

additional information

Aspergillus niger

-

complete inhibition when superoxide dismutase is included in the reaction mixture for the assay of the enzyme

438874

-

additional information

Aspergillus niger

-

not: atebrin, aminopterin

438877

-